Regression of myocardial hypertrophy after aortic valve replacement: Faster in women?

Circulation

Volumn 122, Issue 11 SUPPL. 1, 2010, Pages

  Petrov, George ^a,b   Regitz Zagrosek, Vera ^a,b   Lehmkuhl, Elke ^a,b   Krabatsch, Thomas ^a   Dunkel, Anne ^b   Dandel, Michael ^a   Dworatzek, Elke ^b   Mahmoodzadeh, Shokoufeh ^b   Schubert, Carola ^b   Becher, Eva ^b   Hampl, Hannah ^b   Hetzer, Roland ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

aortic valve stenosis; estrogen; hypertrophy; remodeling; sex

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; ESTRADIOL; GELATINASE A; ESTROGEN; MUSCLE PROTEIN; SCLEROPROTEIN;

AGED; ANIMAL CELL; AORTA VALVE REPLACEMENT; AORTA VALVE STENOSIS; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; FIBROBLAST; GENE EXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; REMISSION; SEX DIFFERENCE; ANIMAL; AORTA VALVE; AORTIC VALVE STENOSIS; BIOSYNTHESIS; CELL CULTURE; COMPLICATION; GENE EXPRESSION REGULATION; HEART VENTRICLE; HYPERTROPHY, LEFT VENTRICULAR; METABOLISM; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY; PROSTHESES AND ORTHOSES; SEXUAL DEVELOPMENT; VERY ELDERLY; WISTAR RAT;

AGED; AGED, 80 AND OVER; ANIMALS; AORTIC VALVE; AORTIC VALVE STENOSIS; CELLS, CULTURED; ESTRADIOL; ESTROGENS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HEART VENTRICLES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; MUSCLE PROTEINS; PROSPECTIVE STUDIES; PROSTHESES AND IMPLANTS; RATS; RATS, WISTAR; SEX CHARACTERISTICS; SEX FACTORS;

EID: 77954525771     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.927764     Document Type: Article

References (23)

1. Carroll JD, Carroll EP, Feldman T, Ward DM, Lang RM, McGaughey D, Karp RB. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation. 1992;86:1099-1107.
2. Douglas PS, Otto CM, Mickel MC, Labovitz A, Reid CL, Davis KB. Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis: NHLBI Balloon Valvuloplasty Registry. Br Heart J. 1995;73: 548-554.
3. Villari B, Campbell SE, Schneider J, Vassalli G, Chiariello M, Hess OM. Sex-dependent differences in left ventricular function and structure in chronic pressure overload. Eur Heart J. 1995;16:1410-1419.
4. Fielitz J, Hein S, Mitrovic V, Pregla R, Zurbrugg HR, Warnecke C, Schaper J, Fleck E, Regitz-Zagrosek V. Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease. J Am Coll Cardiol. 2001;37:1443-1449.
5. Fielitz J, Leuschner M, Zurbrugg HR, Hannack B, Pregla R, Hetzer R, Regitz-Zagrosek V. Regulation of matrix metalloproteinases and their inhibitors in the left ventricular myocardium of patients with aortic stenosis. J Mol Med. 2004;82:809-820.
6. Witt H, Schubert C, Jaekel J, Fliegner D, Penkalla A, Tiemann K, Stypmann J, Roepcke S, Brokat S, Mahmoodzadeh S, Brozova E, Davidson MM, Ruiz Noppinger P, Grohe C, Regitz-Zagrosek V. Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol Med. 2008;86:1013-1024.
7. Fliegner D, Schubert C, Penkalla A, Witt H, Kararigas G, Dworatzek E, Staub E, Martus P, Ruiz Noppinger P, Kintscher U, Gustafsson JA, Regitz-Zagrosek V. Female sex and estrogen receptor {/3} attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1597-R1606.
8. Dubey RK, Gillespie DG, Jackson EK, Keller PJ. 17/3-Estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth. Hypertension. 1998;31:522-528.
9. Zhou L, Shao Y, Huang Y, Yao T, Lu LM. 17/3-Estradiol inhibits angiotensin II-induced collagen synthesis of cultured rat cardiac fibroblasts via modulating angiotensin II receptors. Eur J Pharmacol. 2007; 567:186-192.
10. Cavasin MA, Tao Z, Menon S, Yang XP. Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice. Life Sci. 2004;75:2181-2192.
11. Krayenbuehl HP, Hess OM, Monrad ES, Schneider J, Mall G, Turina M. Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement. Circulation. 1989;79: 744-755.
12. Christakis GT, Joyner CD, Morgan CD, Fremes SE, Buth KJ, Sever JY, Rao V, Panagiotopoulos KP, Murphy PM, Goldman BS. Left ventricular mass regression early after aortic valve replacement. Ann Thorac Surg. 1996;62:1084-1089.
13. Djavidani B, Schmid FX, Keyser A, Butz B, Seitz J, Luchner A, Debl K, Feuerbach S, Nitz WR. Early regression of left ventricular hypertrophy after aortic valve replacement by the Ross procedure detected by cine MRI. J Cardiovasc Magn Reson. 2004;6:1-8.
14. Henry WL, Gardin JM, Ware JH. Echocardiographic measurements in normal subjects from infancy to old age. Circulation. 1980;62: 1054-1061.
15. Kuch B, Hense HW, Gneiting B, Doring A, Muscholl M, Brockel U, Schunkert H. Body composition and prevalence of left ventricular hypertrophy. Circulation. 2000;102:405-410.
16. Mahmoodzadeh S, Dworatzek E, Fritschka S, Pham TH, Regitz-Zagrosek V. 17/3-Estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. Cardiovasc Res. 2010;85:719-728.
17. Tabachnick B, Fidell L. Using Multivariate Statistics. 4th ed. Needham Heights, MA: Allyn & Bacon; 2001.
18. Isensee J, Witt H, Pregla R, Hetzer R, Regitz-Zagrosek V, Noppinger PR. Sexually dimorphic gene expression in the heart of mice and men. J Mol Med. 2008;86:61-74.
19. Dewey FE, Rosenthal D, Murphy DJ Jr, Froelicher VF, Ashley EA. Does size matter? Clinical applications of scaling cardiac size and function for body size. Circulation. 2008;117:2279-2287.
20. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, Anversa P. Gender differences and aging: effects on the human heart. J Am Coll Cardiol. 1995;26:1068-1079.
21. Gray RP, Turner MA, Sheridan DJ, Fry CH. The role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression. Cardiovasc Res. 2007;73: 539-548.
22. Stansfield WE, Rojas M, Corn D, Willis M, Patterson C, Smyth SS, Selzman CH. Characterization of a model to independently study regression of ventricular hypertrophy. J Surg Res. 2007;142:387-393.
23. Yang DK, Choi BY, Lee YH, Kim YG, Cho MC, Hong SE, Kim do H, Hajjar RJ, Park WJ. Gene profiling during regression of pressure overload-induced cardiac hypertrophy. Physiol Genomics. 2007;30:1-7.