IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Journal of Endocrinology

Volumn 175, Issue 1, 2002, Pages 19-31

  Mohan, S ^a   Baylink, D J ^a  

^a LOMA LINDA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GROWTH FACTOR; LIGAND; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; BINDING AFFINITY; CELL MEMBRANE; CELL NUCLEUS; CELL TYPE; CONTROLLED STUDY; ENDOCRINE FUNCTION; GENE ACTIVATION; GENE NUMBER; GROWTH REGULATION; HALF LIFE TIME; HUMAN; HUMAN CELL; HUMAN GENOME; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OSSIFICATION; OSTEOBLAST; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN TRANSPORT; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CARRIER PROTEINS; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; PROTEIN BINDING; RECEPTORS, SOMATOMEDIN; SIGNAL TRANSDUCTION; SOMATOMEDINS;

EID: 0036803018     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1750019     Document Type: Article

References (82)

1. Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ & Mohan S 2002 Insulin-like growth factor binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2). Journal of Biological Chemistry 277 12053-12060.
2. Andress DL 1998 Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor. American Journal of Physiology 274 E744-E750.
3. Andress DL & Birnbaum RS 1992 Human osteoblast-derived insulin-like growth factor (TGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. Journal of Biological Chemistry 267 22467-22472.
4. Andress DL, Loop SM, Zapf J & Kiefer MC 1993 Carboxy-truncated insulin-like growth factor binding protein-5 stimulates mitogenesis in asteoblast-like cells. Biochemical and Biophysical Research Communications 195 25-30.
5. Bautista CM, Baylink DJ & Mohan S 1991 Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGF-II in human bone. Biochemical and Biophysical Research Communications 176 756-763.
6. Baxter RC 2000 Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. American Journal of Physiology 278 E967-E976.
7. Baxter RC, Meka S & Firth SM 2002 Molecular distribution of IGF binding protein-5 in human serum. Journal of Clinical Endocrinology and Metabolism 87 271-276.
8. Boisclair Y, Rhoads RP, Ueki I, Wang J & Ooi GT 2001 The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten comppnent of the circulating IGF system. Journal of Endocrinology 170 63-70.
9. Busby WH Jr, Klapper DG & Clemmons DR 1988 Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. Journal of Biological Chemistry 263 14203-14210.
10. Busby WH Jr, Nam TJ, Moralez A, Smith C, Jennings M & Clemmons DR 2000 The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding protein-5 in fibroblast medium. Journal of Biological Chemistry 275 37638-37644.
11. Butler AA & LeRoith D 2001 Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1 r genes and their roles in insulin-like growth factor physiology. Endocrinology 142 1685-1688.
12. Byun D, Mohan S, Yoo M, Sexton C, Baylink DJ & Qin X 2001 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro. Journal of Clinical Endocrinology and Metabolism 86 847-854.
13. Canalis E, McCarthy TL & Centrella M 1991 Effects of desamino-(1-3)-insulin-like growth factor I on bone cell function in rat calvarial cultures. Endocrinology 129 534-541.
14. Clemmons DR 1998 Role of insulin-like growth factor binding proteins in controlling IGF actions. Molecular and Cellular Endocrinology 140 19-24.
15. Clemmons DR 2001 Use of mutagenesis to probe IGF-binding protein structure/function relationships. Endocrine Reviews 22 800-817.
16. Cohen P, Lamson G, Okajima T & Rosenfeld RG 1993 Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth. Molecular Endocrinology 7 380-386.
17. Cohick WS & Clemmons DR 1993 The insulin-like growth factors. Annual Review of Physiology 55 131-153.
18. Collett-Solberg PF & Cohen P 2000 Genetics, chemistry, and function of the IGF/IGFBP system. Endocrine 12 121-136.
19. Conover CA 1991 Glycosylation of insulin-like growth factor binding protein-3 (IGFBP-3) is not required for potentiation of IGF-I action: evidence for processing of cell-bound IGFBP-3. Endocrinology 129 3259-3268.
20. Conover CA 1995 Insulin-like growth factor binding protein proteolysis in bone cell models. Progress in Growth Factor Research 6 301-309.
21. Conover CA & Powell DR 1991 insulin-like growth factor (IGF)-binding protein-3 blocks IGF-I-induced receptor down-regulation and cell desensitization in cultured bovine fibroblasts. Endocrinology 129 710-716.
22. Conover CA, Faessen GF, Ilg KE, Chandrasekher YA, Christiansen M, Overgaard MT, Oxvig C & Giudice LC 2001 Pregnancy-associated plasma Protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum. Endocrinology 142 2155.
23. Coverley JA & Baxter RC 1997 Phosphorylation of insulin-like growth factor binding proteins. Molecular and Cellular Endocrinology 128 1-5.
24. Daughaday WH 2000 Growth hormone axis overview - somatomedin hypothesis [In Process Citation]. Pediatric Nephrology 14 537-540.
25. Daughaday WH, Trivedi B & Baxter RC 1993 Serum 'big insulin-like growth factor II' from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing. PNAS 90 5823-5927.
26. De Mellow JS & Baxter RC 1999 Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts. Biochemical and Biophysical Research Communications 156 199-204.
27. Ferry RJ Jr, Cerri RW & Cohen P 1999 Insulin-like growth factor binding proteins: new proteins, new functions. Hormone Research 51 53-67.
28. Fowlkes JL, Thrailkill KM, Serra DM, Suzuki K & Nagase H 1995 Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases. Progress in Growth Factor Research 6 255-263.
29. Gill ZP, Perks CM, Newcomb PV & Holly JM 1997 Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. Journal of Biological Chemistry 272 25602-25607.
30. Giudice LC, Farrell EM, Pham H, Lamson G & Rosenfeld RG 1990 Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. Journal of Clinical Endocrinology and Metabolism 71 806-816.
31. Giudice LC, Conover CA, Bale L, Faessen GH, Ilg K, Sun I, Imani B, Suen LF, Irwin JC, Christiansen M, Overgaard MT & Oxvig C 2002 Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation. Journal of Clinical Endocrinology and Metabolism 87 2359-2366.
32. Gleeson LM, Chakraborty C, McKinnon T & Lala PK 2001 Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein kinase pathway. Journal of Clinical Endocrinology and Metabolism 86 2484-2493.
33. Hoeck WG & Mukku VR 1994 Identification of the major sites of phosphorylation in IGF binding protein-3. Journal of Cellular Biochemistry 56 262-273.
34. Hong J, Zhang G, Dong F & Rechler MM 2002 Insulin-like growth factor binding protein-3 (IGFBP-3) mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells. Journal of Biological Chemistry 277 10489-10497.
35. Hossenlopp P, Segovia B, Lassarre C, Roghani M, Bredon M & Binoux M 1990 Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy. Journal of Clinical Endocrinology and Metabolism 71 797-805.
36. Hwa V, Oh Y & Rosenfeld RG 1999 The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocrine Reviews 20 761-787.
37. Jones JI, D'Ercole AJ, Camacho-Hubner C & Clemmons DR 1991 Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I. PNAS 88 7481-7485.
38. Jones JI, Gockerman A, Busby WH, Camacho-Hubner C & Clemmons DR 1993a Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I. Journal of Cell Biology 121 679-687.
39. Jones JI, Gockerman A, Busby WH Jr, Wright G & Clemmons DR, 1993b Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. PNAS 90 10553-10557.
40. Kelley KM, Oh Y, Gargosky SE, Gucev Z, Matsumoto T, Hwa V, Ng L, Simpson DM & Rosenfeld RG 1996 Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. International Journal of Biochemistry and Cell Biology 28 619-637.
41. Koistinen R, Kalkkinen N, Huhtala ML, Seppala M, Bohn H & Rutanen EM 1986 Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Endocrinology 118 1375-1378.
42. Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR III & Conover CA 1999 The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. PNAS 96 3149-3153.
43. Leal SM, Liu Q, Huang SS & Huang JS 1997 The type V transforming growth factor beta receptor is the putative insulin-like growth factor-binding protein 3 receptor. Journal of Biological Chemistry 272 20572-20576.
44. Liu JP, Baker J, Perkins AS, Robertson EJ & Efstratiadis A 1993 Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 59-72.
45. Liu JL, Grinberg A, Westphal H, Sauer B, Accili D, Karas M & LeRoith D 1998 Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Molecular Endocrinology 12 1452-1462.
46. Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM & Cohen P 2000 Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. Journal of Biological Chemistry 275 33607-33613.
47. Maile LA & Holly JM 1999 Insulin-like growth factor binding protein (IGFBP) proteolysis: occurrence, identification, role and regulation. Growth Hormone and IGF Research 9 85-95.
48. Malpe R, Baylink DJ, Linkhart TA, Wergedal JE & Mohan S 1997 Insulin-like growth factor (IGF)-I, -II, IGF binding proteins (IGFBP)-3, -4, and -5 levels in the conditioned media of normal human bone cells are skeletal site-dependent. Journal of Bone and Mineral Research 12 423-430.
49. Miyakoshi N, Richman C, Qin X, Baylink DJ & Mohan S 1999 Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Endocrinology 140 5719-5728.
50. Miyakoshi N, Qin X, Kasukawa Y, Richman C, Srivastava AK, Baylink DJ & Mohan S 2001a Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism. Endocrinology 142 2641-2648.
51. Miyakoshi N, Richman C, Kasukawa Y, Linkhart TA, Baylink DJ & Mohan S 2001b Evidence that IGF-binding protein-5 functions as a growth factor. Journal of Clinical Investigation 107 73-81.
52. Mohan S & Baylink DJ 1991 Bone growth factors. Clinical Orthopaedics 263 30-48.
53. Mohan S & Baylink DJ 1996 Insulin-like growth factor (IGF)-binding proteins in serum - do they have additional roles besides modulating the endocrine IGF actions? [editorial]. Journal of Clinical Endocrinology and Metabolism 81 3817-3820.
54. Mohan S & Baylink DJ 1999 IGF system components and their role in bone metabolism. In IGFs in Health and Disease, pp 457-496. Eds RG Rosenfeld & CT Roberts. New Jersey: Humana Press.
55. Mohan S, Farley JR & Baylink DJ 1995a Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging. Progress in Growth Factor Research 6 465-473.
56. Mohan S, Nakao Y, Honda Y, Landale E, Leser U, Dony C, Lang K & Baylink DJ 1995b Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. Journal of Biological Chemistry 270 20424-20431.
57. Mohan S, Richman C, Guo R, Libanati CR, Wergedal JE, Baylink DJ 2000 Skeletal changes in mice lacking IGF-I or IGF-II gene: evidence for a critical role for IGFs in bone accretion during puberty. Journal of Bone and Mineral Research 15 (Suppl 1) S147.
58. Mohan S, Thompson G, Amaar Y, Hathaway G, Tschesche H, Baylink DJ 2002 ADAM-9 is an IGFBP-5 protease produced and secreted by human osteoblasts. Procedings of the Endocrine Society, 84th Annual Meeting, San Francisco, CA, 2002.
59. Muller JM, Isele U, Metzger E, Rempel A, Moser M, Pscherer A, Breyer T, Holubarsch C, Buettner R & Schule R 2000 FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO Journal 19 359-369.
60. Nicolas V, Mohan S, Honda Y, Prewett A, Finkelman RD, Baylink DJ & Farley JR 1995 An age-related decrease in the concentration of insulin-like growth factor binding protein-5 in human cortical bone. Calcified Tissue International 57 206-212.
61. Oh Y 1998 IGF-independent regulation of breast cancer growth by IGF binding proteins. Breast Cancer Research and Treatment 47 283-293.
62. Oh Y, Muller HL, Lamson G & Rosenfeld RG 1993 Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. Journal of Biological Chemistry 268 14964-14971.
63. Perks CM, Newcomb PV, Norman MR & Holly JM 1999 Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells. Journal of Molecular Endocrinology 22 141-150.
64. Poretsky L, Cataldo NA, Rosenwaks Z & Giudice LC 1999 The insulin-related ovarian regulatory system in health and disease. Endocrine Reviews 20 535-582.
65. Qin X, Strong DD, Baylink DJ & Mohan S 1998 Structure-function analysis of the human insulin-like growth factor binding protein-4. Journal of Biological Chemistry 273 23509-23516.
66. Qin X, Byun D, Lau KW, Baylink DJ & Mohan S 2000 Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II dependent IGFBP-4 protease. Archives of Biochemistry and Biophysics 379 209-216.
67. Radulescu RT 1994 Nuclear localization signal in insulin-like growth factor-binding protein type 3. Trends in Biochemical Sciences 19 278.
68. Rajah R, Katz L, Nunn S, Solberg P, Beers T & Cohen P 1995 insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. Progress in Growth Factor Research 6 273-284.
69. Rajah R, Valentinis B & Cohen P 1997 Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism. Journal of Biological Chemistry 272 12181-12188.
70. Rajaram S, Baylink DJ & Mohan S 1997 Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocrine Reviews 18 801-931.
71. Rechler MM 1993 Insulin-like growth factor binding proteins. Vitamins and Hormones 47 1-114.
72. Richman C, Baylink DJ, Lang K, Dony C & Mohan S 1999 Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. Endocrinology 140 4699-4705.
73. Schedlich LJ, LePage SL, Firth SM, Briggs LJ, Jans DA & Baxter RC 2000 Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. Journal of Biological Chemistry 275 23462-23470.
74. Stewart CE & Rotwein P 1996 Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiology Reviews 76 1005-1026.
75. Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC & Ballard FJ 1992 Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochemical Journal 282 91-97.
76. Twigg SM, Kiefer MC, Zapf J & Baxter RC 1998 Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. Journal of Biological Chemistry 273 28791-28798.
77. Valentinis B, Bhala A, DeAngelis T, Baserga R & Cohen P 1995 The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Molecular Endocrinology 9 361-367.
78. Villaudy J, Delbe J, Blat C, Desauty G, Golde A & Harel L 1991 An IGF binding protein is an inhibitor of FGF stimulation. Journal of Cellular Physiology 149 492-496.
79. Wang J, Niu W, Witte DP, Chernausek SD, Nikiforov YE, Clemens TL, Sharifi B, Strauch AR & Fagin JA 1998 Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology 139 2605-2614.
80. Zadeh SM & Binoux M 1997 The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type 1 IGF receptor gene. Endocrinology 138 3069-3072.
81. Zapf J 1994 Role of insulin-like growth factor II and IGF binding proteins in extrapancreatic tumor hypoglycemia. Hormone Research 42 20-26.
82. Zapf J 1995 Physiological role of the insulin-like growth factor binding proteins. European Journal of Endocrinology 132 645-654.