A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people

Biogerontology

Volumn 12, Issue 3, 2011, Pages 265-271

  Crocco, Paolina ^a   Montesanto, Alberto ^a   Passarino, Giuseppe ^a   Rose, Giuseppina ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Aging; Hand grip strength; Uncoupling protein

Indexed keywords

UNCOUPLING PROTEIN 3;

AGED; ALLELE; ARTICLE; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HAND GRIP; HAND MUSCLE; HETEROZYGOTE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

AGED; FEMALE; HAND STRENGTH; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 79958097486     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-011-9321-z     Document Type: Article

References (57)

1. Arking DE, Fallin DM, Fried LP, Li T, Beamer BA, Xue QL, Chakravarti A, Walston J (2006) Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women. J Am Geriatr Soc 54(5):823-826 (Pubitemid 44030206)
2. Balagopal P, Proctor D, Nair KS (1997) Sarcopenia and hormonal changes. Endocrine 7(1):57-60 (Pubitemid 127483087)
3. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408(1): 39-42 (Pubitemid 27216458)
4. Carlson BM (1995) Factors influencing the repair and adaptation of muscles in aged individuals: satellite cells and innervation. J Gerontol A Biol Sci Med Sci 50 Spec No:96-100
5. Carmeli E, Reznick AZ, Coleman R, Carmeli V (2000) Muscle strength and mass of lower extremities in relation to functional abilities in elderly adults. Gerontology 46(5): 249-257
6. Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BW, Williams GR, Atkinson H, Martin A, Guralnik JM, Ferrucci L (2004) Antioxidants and physical performance in elderly persons: the invecchiare in chianti (InCHIANTI) study. Am J Clin Nutr 79(2):289-294 (Pubitemid 41095983)
7. Chung SS, Weindruch R, Schwarze SR, McKenzie DI, Aiken JM (1994) Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging 6(3):193-200
8. Cortopassi GA, Arnheim N (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18(23):6927-6933 (Pubitemid 120006077)
9. Cortopassi GA, Shibata D, Soong NW, Arnheim N (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci 89(16):7370-7374
10. Dardevet D, Sornet C, Balage M, Grizard J (2000) Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. J Nutr 130(11):2630-2635
11. Dato S, Krabbe KS, Thinggaard M, Pedersen BK, Christensen K, Bruunsgaard H, Christiansen L (2010) Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. J Gerontol A Biol Sci Med Sci 65(3):225-235
12. De Mars G, Windelinckx A, Beunen G, Delecluse C, Lefevre J, Thomis MA (2007) Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. J Appl Physiol 102(5):1824-1831 (Pubitemid 46701950)
13. Doherty TJ (2003) Invited review: aging and sarcopenia. J Appl Physiol 95(4):1717-1727
14. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ,Morrison A, Pickering S, Clapham JC, Brand MD (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415(6867):96-99 (Pubitemid 34062457)
15. Excoffier L, Laval G, Schneider S (2005) Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol Bioinform Online 1:47-50
16. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ (1994) Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330(25):1769-1775 (Pubitemid 24177611)
17. Frederiksen H, Gaist D, Petersen HC, Hjelmborg J, McGue M, Vaupel JW, Christensen K (2002) Hand grip strength: a phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning. Genet Epidemiol 23(2):110-122 (Pubitemid 34977113)
18. Giampaoli S, Ferrucci L, Cecchi F, Lo Noce C, Poce A, Dima F, Santaquilani A, Vescio MF, Menotti A (1999) Handgrip strength predicts incident disability in non-disabled older men. Age Ageing 28(3):283-288 (Pubitemid 29229332)
19. Gong DW, He Y, Karas M, Reitman M (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem 272(39):24129-24132 (Pubitemid 27418606)
20. Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50(5):889-896 (Pubitemid 34496687)
21. Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R (2004) The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 52(1):80-85 (Pubitemid 38090394)
22. Jozsi AC, Campbell WW, Joseph L, Davey SL, Evans WJ (1999) Changes in power with resistance training in older and younger men and women. J Gerontol A Biol Sci Med Sci 54(11):M591-M596 (Pubitemid 30017621)
23. Larkin S, Mull E, Miao W, Pittner R, Albrandt K, Moore C, Young A, Denaro M, Beaumont K (1997) Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Biochem Biophys Res Commun 240(1):222-227 (Pubitemid 27503779)
24. Larsson L (1995) Motor units: remodeling in aged animals. J Gerontol A Biol Sci Med Sci 50 Spec No: 91-95
25. Lee CM, Chung SS, Kaczkowski JM, Weindruch R, Aiken JM (1993) Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol 48(6):B201-B205 (Pubitemid 23333629)
26. Lexell J (1995) Human aging, muscle mass, and fiber type composition. J Gerontol A Biol Sci Med Sci 50 Spec No:11-16
27. Lexell J (1997) Evidence for nervous system degeneration with advancing age. J Nutr 127(5 Suppl):1011S-1013S
28. Lexell J, Taylor CC, Sjostrom M (1988) What is the cause of the ageing atrophy? total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15 to 83 year old men. J Neurol Sci 84(2-3): 275-294 (Pubitemid 18087270)
29. Linnane AW, Baumer A, Maxwell RJ, Preston H, Zhang CF, Marzuki S (1990) Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem Int 22(6):1067-1076
30. McKenzie D, Bua E, McKiernan S, Cao Z, Aiken JM (2002) Mitochondrial DNA deletion mutations: a causal role in sarcopenia. Eur J Biochem 269(8):2010-2015 (Pubitemid 34437842)
31. Meissner C, Bruse P, Oehmichen M (2006) Tissue-specific deletion patterns of the mitochondrial genome with advancing age. Exp Gerontol 41(5):518-524 (Pubitemid 43765895)
32. Melov S, Hertz GZ, Stormo GD, Johnson TE (1994) Detection of deletions in the mitochondrial genome of Caenorhabditis elegans. Nucleic Acids Res 22(6):1075-1078 (Pubitemid 24162172)
33. Meng SJ, Yu LJ (2010) Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 11(4):1509-1526
34. Metter EJ, Talbot LA, Schrager M, Conwit R (2002) Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci 57(10): B359-B365
35. Mookerjee SA, Divakaruni AS, Jastroch M, Brand MD (2010) Mitochondrial uncoupling and lifespan. Mech Ageing Dev 131(7-8):463-472
36. Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS (2001) Sarcopenia. J Lab Clin Med 137(4):231-243 (Pubitemid 32296061)
37. Nabben M, Hoeks J, Briede JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. FEBS Lett 582(30):4147-4152
38. Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ (1994) Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. JAMA 272(24):1909-1914
39. Newman AB, Kupelian V, Visser M, Simonsick EM, Goodpaster BH, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB (2006) Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci 61(1):72-77 (Pubitemid 43227803)
40. Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, White L (1999) Midlife hand grip strength as a predictor of old age disability. JAMA 281(6):558-560 (Pubitemid 29081310)
41. Rantanen T, Volpato S, Ferrucci L, Heikkinen E, Fried LP, Guralnik JM (2003) Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc 51(5):636-641 (Pubitemid 36541427)
42. Ronkainen PH, Pollanen E, Tormakangas T, Tiainen K, Koskenvuo M, Kaprio J, Rantanen T, Sipila S, Kovanen V (2008) Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity. PLoS One 3(3):e1819
43. Roth SM, Schrager MA, Ferrell RE, Riechman SE, Metter EJ, Lynch NA, Lindle RS, Hurley BF (2001) CNTF genotype is associated with muscular strength and quality in humans across the adult age span. J Appl Physiol 90(4):1205-1210 (Pubitemid 32220900)
44. Roubenoff R (2000a) Sarcopenia and its implications for the elderly. Eur J Clin Nutr 54(Suppl 3):S40-S47
45. Roubenoff R (2000b) Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging 4(3):140-142
46. Roubenoff R (2003) Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 6(3):295-299
47. Roubenoff R, Hughes VA (2000) Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci 55(12):M716-M724 (Pubitemid 32175754)
48. Roubenoff R, Parise H, Payette HA, Abad LW, D'Agostino R, Jacques PF, Wilson PW, Dinarello CA, Harris TB (2003) Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham heart study. Am J Med 115(6): 429-435 (Pubitemid 37237554)
49. Schrager M, Bandinelli S, Maggi S, Ferrucci L (2003) Sarcopenia: twenty open questions for a research agenda. Basic Appl Myol 13(4):203-208 (Pubitemid 36892006)
50. Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E (1999) A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. Int J Obes Relat Metab Disord 23(12):1242-1245 (Pubitemid 30011948)
51. Visser M (2009) Towards a definition of sarcopenia - results from epidemiologic studies. J Nutr Health Aging 13(8): 713-716
52. Walsh S, Liu D, Metter EJ, Ferrucci L, Roth SM (2008) ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J Appl Physiol 105(5):1486-1491
53. Walsh S, Kelsey BK, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Seip RL, Bilbie S, Thompson PD, Hoffman EP, Price TB, Devaney JM, Pescatello LS (2009) CNTF 1357 G > a polymorphism and the muscle strength response to resistance training. J Appl Physiol 107(4):1235-1240
54. Wanagat J, Cao Z, Pathare P, Aiken JM (2001) Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J 15(2):322-332 (Pubitemid 32141424)
55. Weigle DS, Selfridge LE, Schwartz MW, Seeley RJ, Cummings DE, Havel PJ, Kuijper JL, BeltrandelRio H (1998) Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes 47(2):298-302 (Pubitemid 28079993)
56. Weir BS (1996) Genetic data analysis II : methods for discrete population genetic data. Sinauer Associates, Sunderland
57. Yu XX, Barger JL, Boyer BB, Brand MD, Pan G, Adams SH (2000) Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics. Am J Physiol Endocrinol Metab 279(2): E433-E446