Tissue-specific deletion patterns of the mitochondrial genome with advancing age

Experimental Gerontology

Volumn 41, Issue 5, 2006, Pages 518-524

  Meissner, Christoph ^a   Bruse, Petra ^a   Oehmichen, Manfred ^a,b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Aging; Human tissue; Large scale deletions; Mitochondrial DNA

Indexed keywords

MITOCHONDRIAL DNA;

AGING; ARTICLE; CAUDATE NUCLEUS; CEREBELLUM; GENE DELETION; HUMAN; HUMAN TISSUE; MITOCHONDRIAL GENETICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SKELETAL MUSCLE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CAUDATE NUCLEUS; CEREBELLUM; CHILD; CHILD, PRESCHOOL; DNA, MITOCHONDRIAL; FEMALE; GENE DELETION; GENOME; HUMANS; INFANT; MALE; MIDDLE AGED; MITOCHONDRIA, HEART; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; POLYMERASE CHAIN REACTION;

MAMMALIA;

EID: 33646807843     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.03.010     Document Type: Article

References (35)

1. Albers D.S., and Beal M.F. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J. Neural. Transm. 59 (2000) 133-154
2. Ballard J.W., and Dean M.D. The mitochondrial genome: mutation, selection and recombination. Curr. Opin. Genet. Dev. 11 (2001) 667-672
3. Bank C., Soulimane T., Schröder M., Buse G., and Zassen S. Multiple deletions of mtDNA remove the light strand origin of replication. Biochem. Biophys. Res. Commun. 279 (2000) 595-601
4. Bua E.A., McKiernan S.H., Wanagat J., McKenzie D., and Aiken J.M. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J. Appl. Physiol. 92 (2002) 2617-2624
5. Chabi B., de Camaret B.M., Chevrollier A., Boisgard S., and Stepien G. Random mtDNA deletions and functional consequence in aged human skeletal muscle. Biochem. Biophys. Res. Commun. 332 (2005) 542-549
6. Chance B., Sies H., and Broveris A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59 (1979) 527-605
7. Corral-Debrinski M., Horton T., Lott M.T., Shoffner J.M., Beal M.F., and Wallace D.C. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2 (1992) 324-329
8. Cortopassi G.A., Shibata D., Soong N.W., and Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl Acad. Sci. 89 (1992) 7370-7374
9. Elson J.L., Samuels D.C., Turnbull D.M., and Chinnery P.F. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 68 (2001) 802-806
10. Gokey N.G., Cao Z., Pak J.W., Lee D., McKiernan S.H., McKenzie D., Weindruch R., and Aiken J.M. Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys. Aging Cell 3 (2001) 319-326
11. Graeber M.B., Grasbon-Frodl E., Eitzen U.V., and Kösel S. Neurodegeneration and aging: role of the second genome. J. Neurosci. Res. 52 (1998) 1-6
12. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
13. Hasty P. The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice. Mech. Ageing. Dev. 126 (2005) 71-77
14. Hayakawa M., Katsumata K., Yoneda M., Tanaka M., Sugiyama S., and Ozawa T. Age-related extensive fragmentation of mitochondrial DNA into minicircles. Biochem. Biophys. Res. Commun. 226 (1996) 369-377
15. Hutchison III C.A., Smith H.O., Pfannkoch C., and Venter C. Cell-free cloning using phi29 DNA polymerase. Proc. Natl Acad. Sci. USA 102 (2005) 17332-17336
16. Kajander O.A., Poulton J., Spelbrink J.N., Rovio A.T., Karhunen P.J., and Jacobs H.T. The dangers of extended PCR in the clinic. Nat Med. 5 (1999) 965-966
17. Kajander O.A., Rovio A.T., Majamaa K., Poulton J., Spelbrink J.N., Holt I.J., Karhunen P.J., and Jacobs H.T. Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states. Hum. Mol. Genet. 9 (2000) 2821-2835
18. Khrapko K., Nekhaeva E., Kratysberg Y., and Kunz W. Clonal expansions of mitochondrial genomes: implications for in vivo mutational spectra. Mutat. Res. 522 (2003) 13-19
19. Kovalenko S.A., Kopsidas G., Kelso J.M., and Linnane A.W. Deltoid human muscle mtDNA is extensively rearranged in old age subjects. Biochem. Biophys. Res. Comm. 232 (1997) 147-152
20. Lee C.M., Lopez M.E., Weindruch R., and Aiken J.M. Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic. Biol. Med. 25 (1998) 964-972
21. Lezza A.M., Mecocci P., Cormio A., Beal M.F., Cherubini A., Cantatore P., Senin U., and Gadaleta M.N. Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients. FASEB J. 13 (1999) 1083-1088
22. Melov S., Shoffner J.M., Kaufman A., and Wallace D.C. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res. 23 (1995) 4122-4126
23. Phadnis N., Sia R.A., and Sia E.A. Analysis of repeat-mediated deletions in the mitochondrial genome of Saccharomyces cerevisiae. Genetics 12 (2005) (Sep 12 as 10.1543/genetics.105.047092)
24. Prado F., Cortes-Ledesma F., Huertas P., and Aguilera A. Mitotic recombination in Saccharomyces cerevisiae. Curr. Genet. 42 (2003) 185-198
25. Rasmussen U.F., Krustrup P., Kjaer M., and Rasmussen H.N. Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria. Exp. Gerontol. 38 (2003) 877-886
26. Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int. J. Biochem. Cell Biol. 27 (1995) 647-653
27. Shoffner J.M., Lott M.T., Voljavec A.S., Soueidan S.A., Costigan D.A., and Wallace D.C. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc. Natl Acad. Sci. USA 86 (1989) 7952-7956
28. Soong N.W., Hinton D.R., Cortopassi G., and Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat. Genet. 2 (1992) 318-323
29. Srivastava S., and Moraes C.T. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum. Mol. Genet. 14 (2005) 893-902
30. Storm T., Rath S., Mohamed S.A., Bruse P., Kowald A., Oehmichen M., and Meissner C. Mitotic brain cells are just as prone to mitochondrial deletions as neurons: a large-scale single-cell PCR study of the human caudate nucleus. Exp. Gerontol. 37 (2002) 1387-1398
31. Taylor R.W., Barron M.J., Borthwick G.M., Gospel A., Chinnery P.F., Samuels D.C., Taylor G.A., Plusa S.M., Needham S.J., Kirkwood T.B., Greaves L.C., and Turnbull D.M. Mitochondrial DNA mutations in human colonic crypt stem cells. J. Clin. Invest. 112 (2003) 1351-1360
32. Tsay H.J., Wang P., Wang S.L., and Ku H.H. Age-associated changes of superoxide dismutase and catalase activities in the rat brain. J. Biomed. Sci. 7 (2000) 466-474
33. Wallace D.C. Mitochondrial DNA in aging and disease. Sci. Am. 277 (1997) 40-47
34. Wanagat J., Cao Z., Pathare P., and Aiken J.M. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J. 15 (2001) 322-332
35. Zeviani M., Spinazzola A., and Carelli V. Nuclear genes in mitochondrial disorders. Curr. Opin. Genet. Dev. 13 (2003) 262-270