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Volumn 66, Issue 1, 2011, Pages 5-12

Antisperm Contraceptive Vaccines: Where We Are and Where We Are Going?

Author keywords

Contraception; Infertility; Sperm; Vaccines

Indexed keywords

A9D PROTEIN; ANTISPERM CONTRACEPTIVE VACCINE; CONTRACEPTIVE VACCINE; CPG OLIGODEOXYNUCLEOTIDE; CV ANTIGEN; DNA VACCINE; EPIDIDYMAL PROTEIN INHIBITOR; FA 1 ANTIGEN; FREUND ADJUVANT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IZUMO PROTEIN; LDH C4 PROTEIN; P10G PROTEIN; PEPTIDE VACCINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SP56 PROTEIN; SPERM ANTIBODY; SPERM ANTIGEN; TESTIS SPECIFIC ANTIGEN 1; UNCLASSIFIED DRUG; YLP 12 ANTIGEN; ZONA PELLUCIDA PROTEIN; ZONA PELLUCIDA PROTEIN 3;

EID: 79958085047     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2011.01000.x     Document Type: Review
Times cited : (43)

References (54)
  • 1
    • 79958143550 scopus 로고    scopus 로고
    • World POPClock Projection: US Census Bureau. Available at (Accessed on January 1)
    • World POPClock Projection: US Census Bureau. Available at (Accessed on January 1, 2011).
    • (2011)
  • 2
    • 0344541755 scopus 로고    scopus 로고
    • Unintended pregnancy in the United States
    • Henshaw SK: Unintended pregnancy in the United States. Fam Plann Perspect 1998; 30:24-29.
    • (1998) Fam Plann Perspect , vol.30 , pp. 24-29
    • Henshaw, S.K.1
  • 3
    • 3342894947 scopus 로고    scopus 로고
    • Contraceptive failure in the United States
    • Trussel J: Contraceptive failure in the United States. Contraception 2004; 70:89-96.
    • (2004) Contraception , vol.70 , pp. 89-96
    • Trussel, J.1
  • 4
    • 79958128698 scopus 로고    scopus 로고
    • WHO/63 News Release, November 1
    • WHO/63 News Release, November 1, 2006.
    • (2006)
  • 5
    • 28544431623 scopus 로고    scopus 로고
    • Recent advances in contraceptive vaccine development: a mini-review
    • Naz RK, Gupta SK, Gupta JC, Vyas HK, Talwar GP: Recent advances in contraceptive vaccine development: a mini-review. Hum Reprod 2005; 20:3271-3283.
    • (2005) Hum Reprod , vol.20 , pp. 3271-3283
    • Naz, R.K.1    Gupta, S.K.2    Gupta, J.C.3    Vyas, H.K.4    Talwar, G.P.5
  • 8
    • 79958158866 scopus 로고    scopus 로고
    • eds): Springer-Verlag, Berlin, Heidelberg, Germany
    • Krause WKH, Naz RK (eds): Immune Infertility. Springer-Verlag, Berlin, Heidelberg, Germany, 2009; pp. 1-236.
    • (2009) Immune Infertility , pp. 1-236
    • Krause, W.K.H.1    Naz, R.K.2
  • 9
    • 0021250819 scopus 로고
    • Effect of ingested sperm on fecundity in the rat
    • Allardyce RA: Effect of ingested sperm on fecundity in the rat. J Exp Med 1984; 159:1548-1553.
    • (1984) J Exp Med , vol.159 , pp. 1548-1553
    • Allardyce, R.A.1
  • 10
    • 0002025206 scopus 로고
    • Immunological control of fertility in female mice
    • Edwards RG: Immunological control of fertility in female mice. Nature 1964; 203:50-53.
    • (1964) Nature , vol.203 , pp. 50-53
    • Edwards, R.G.1
  • 11
    • 0014884676 scopus 로고
    • Immune reactions and infertility
    • Menge AC: Immune reactions and infertility. J Reprod Fertil Suppl 1970; 10:171-185.
    • (1970) J Reprod Fertil Suppl , vol.10 , pp. 171-185
    • Menge, A.C.1
  • 12
    • 0000238998 scopus 로고
    • Temporary sterilization by injection of human spermatozoa: a preliminary report
    • Baskin MJ: Temporary sterilization by injection of human spermatozoa: a preliminary report. Am J Obstet Gynecol 1932; 24:892-897.
    • (1932) Am J Obstet Gynecol , vol.24 , pp. 892-897
    • Baskin, M.J.1
  • 14
    • 0032727013 scopus 로고    scopus 로고
    • Vaccine for contraception targeting sperm
    • Naz RK: Vaccine for contraception targeting sperm. Immunol Rev 1999; 171:193-202.
    • (1999) Immunol Rev , vol.171 , pp. 193-202
    • Naz, R.K.1
  • 15
    • 79958165664 scopus 로고    scopus 로고
    • The Mouse genome and the measure of man. NIH News Advisory, Retrieved from
    • The Mouse genome and the measure of man. NIH News Advisory, Retrieved from, 2002.
    • (2002)
  • 16
    • 21344475101 scopus 로고    scopus 로고
    • Novel testis/sperm-specific contraceptive targets identified using gene knockout studies
    • Naz RK, Rajesh P: Novel testis/sperm-specific contraceptive targets identified using gene knockout studies. Front Biosci 2005; 10:2430-2446.
    • (2005) Front Biosci , vol.10 , pp. 2430-2446
    • Naz, R.K.1    Rajesh, P.2
  • 17
    • 63849136002 scopus 로고    scopus 로고
    • Rajnee: gene knockouts that affect male fertility: novel targets for contraception
    • Naz RK, Engle A: Rajnee: gene knockouts that affect male fertility: novel targets for contraception. Front Biosci 2009; 14:3994-4001.
    • (2009) Front Biosci , vol.14 , pp. 3994-4001
    • Naz, R.K.1    Engle, A.2
  • 18
    • 0030935664 scopus 로고    scopus 로고
    • Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects
    • Zhu X, Naz RK: Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA 1997; 94:4704-4709.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4704-4709
    • Zhu, X.1    Naz, R.K.2
  • 19
    • 0033959872 scopus 로고    scopus 로고
    • Identification of human sperm peptide sequence involved in egg binding for immunocontraception
    • Naz RK, Zhu X, Kadam AL: Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol Reprod 2000; 62:318-324.
    • (2000) Biol Reprod , vol.62 , pp. 318-324
    • Naz, R.K.1    Zhu, X.2    Kadam, A.L.3
  • 20
    • 0034903667 scopus 로고    scopus 로고
    • Cloning and sequencing of cDNA encoding for a novel human testis-specific contraceptive vaccinogen: role in immunocontraception
    • Naz RK, Zhu X, Kadam AL: Cloning and sequencing of cDNA encoding for a novel human testis-specific contraceptive vaccinogen: role in immunocontraception. Mol Reprod Dev 2001; 60:116-127.
    • (2001) Mol Reprod Dev , vol.60 , pp. 116-127
    • Naz, R.K.1    Zhu, X.2    Kadam, A.L.3
  • 21
    • 0034910610 scopus 로고    scopus 로고
    • Novel human testis-specific cDNA: molecular cloning, expression and immunobiological effects of the recombinant protein
    • Santhanam R, Naz RK: Novel human testis-specific cDNA: molecular cloning, expression and immunobiological effects of the recombinant protein. Mol Reprod Dev 2001; 60:1-12.
    • (2001) Mol Reprod Dev , vol.60 , pp. 1-12
    • Santhanam, R.1    Naz, R.K.2
  • 22
    • 0030846202 scopus 로고    scopus 로고
    • Colinear synthesis of an antigen-specific B-cell epitope with a promiscuous tetanus toxin T-cell epitope: a synthetic peptide immunocontraceptive
    • O'Hearn PA, Liang ZG, Bambra CS, Goldberg E: Colinear synthesis of an antigen-specific B-cell epitope with a promiscuous tetanus toxin T-cell epitope: a synthetic peptide immunocontraceptive. Vaccine 1997; 15:1761-1766.
    • (1997) Vaccine , vol.15 , pp. 1761-1766
    • O'Hearn, P.A.1    Liang, Z.G.2    Bambra, C.S.3    Goldberg, E.4
  • 23
    • 0027751727 scopus 로고
    • Inhibition of fertility in female mice by immunization with a B-cell epitope, the synthetic sperm peptide, P10G
    • O'Rand MG, Beavers J, Widgren E, Tung K: Inhibition of fertility in female mice by immunization with a B-cell epitope, the synthetic sperm peptide, P10G. J Reprod Immunol 1993; 25:89-102.
    • (1993) J Reprod Immunol , vol.25 , pp. 89-102
    • O'Rand, M.G.1    Beavers, J.2    Widgren, E.3    Tung, K.4
  • 25
    • 0032923491 scopus 로고    scopus 로고
    • Expression of recombinant mouse sperm protein sp56 and assessment of its potential for use as an antigen in an immunocontraceptive vaccine
    • Hardy CM, Mobbs JK: Expression of recombinant mouse sperm protein sp56 and assessment of its potential for use as an antigen in an immunocontraceptive vaccine. Mol Reprod Dev 1999; 52:527-536.
    • (1999) Mol Reprod Dev , vol.52 , pp. 527-536
    • Hardy, C.M.1    Mobbs, J.K.2
  • 27
    • 15044362481 scopus 로고    scopus 로고
    • The immunoglobin superfamily protein izumo is required for sperm to fuse with eggs
    • Inoue N, Ikawa M, Isotani A, Okabe M: The immunoglobin superfamily protein izumo is required for sperm to fuse with eggs. Nature 2005; 434:234-238.
    • (2005) Nature , vol.434 , pp. 234-238
    • Inoue, N.1    Ikawa, M.2    Isotani, A.3    Okabe, M.4
  • 28
    • 0028027573 scopus 로고
    • Molecular identities of human sperm proteins that bind human zona pellucida: nature of sperm-zona interaction, tyrosine kinase activity and involvement of FA-1
    • Naz RK, Ahmad K: Molecular identities of human sperm proteins that bind human zona pellucida: nature of sperm-zona interaction, tyrosine kinase activity and involvement of FA-1. Mol Reprod Dev 1994; 39:397-408.
    • (1994) Mol Reprod Dev , vol.39 , pp. 397-408
    • Naz, R.K.1    Ahmad, K.2
  • 29
    • 73149123137 scopus 로고    scopus 로고
    • Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system
    • Naz RK, Dhandapani L: Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. J Reprod Immun 2010; 84:24-31.
    • (2010) J Reprod Immun , vol.84 , pp. 24-31
    • Naz, R.K.1    Dhandapani, L.2
  • 30
    • 79958126947 scopus 로고
    • Characterization of fertilization antigen 2 for the development of a contraceptive vaccine
    • Naz RK, Phillips TM, Rosenblum BB: Characterization of fertilization antigen 2 for the development of a contraceptive vaccine. Proc Natl Acad Sci USA 1986; 225:342-344.
    • (1986) Proc Natl Acad Sci USA , vol.225 , pp. 342-344
    • Naz, R.K.1    Phillips, T.M.2    Rosenblum, B.B.3
  • 31
    • 0022261056 scopus 로고
    • Mouse sperm antigens tat participate in fertilization. III. Passive immunization with a single monoclonal antisperm antibody inhibits pregnancy and fertilization in vivo
    • Saling PM, Waibel R: Mouse sperm antigens tat participate in fertilization. III. Passive immunization with a single monoclonal antisperm antibody inhibits pregnancy and fertilization in vivo. Bio Reprod 1985; 33:537-544.
    • (1985) Bio Reprod , vol.33 , pp. 537-544
    • Saling, P.M.1    Waibel, R.2
  • 32
    • 0025043284 scopus 로고
    • Effects of sperm-reactive antibodies present in human infertile sera on fertility of female rabbits
    • Naz RK: Effects of sperm-reactive antibodies present in human infertile sera on fertility of female rabbits. J Reprod Immunol 1990; 18:161-177.
    • (1990) J Reprod Immunol , vol.18 , pp. 161-177
    • Naz, R.K.1
  • 33
    • 0031793644 scopus 로고    scopus 로고
    • Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice
    • Naz RK, Zhu X: Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. Biol Reprod 1998; 59:1095-1100.
    • (1998) Biol Reprod , vol.59 , pp. 1095-1100
    • Naz, R.K.1    Zhu, X.2
  • 34
    • 0035992913 scopus 로고    scopus 로고
    • Human sperm-specific peptide vaccine that causes long-term reversible contraception
    • Naz RK, Chauhan S: Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 2002; 64:674-680.
    • (2002) Biol Reprod , vol.64 , pp. 674-680
    • Naz, R.K.1    Chauhan, S.2
  • 35
    • 45249121546 scopus 로고    scopus 로고
    • Evaluation of the potential of synthetic peptides of 80kDa human sperm antigen (80kDa HSA) for the development of contraceptive vaccine for male
    • Khobarekar BG, Vernekar V, Raghavan V, Kamada M, Maegawa M, Bandivdekar AH: Evaluation of the potential of synthetic peptides of 80kDa human sperm antigen (80kDa HSA) for the development of contraceptive vaccine for male. Vaccine 2008; 26:3711-3718.
    • (2008) Vaccine , vol.26 , pp. 3711-3718
    • Khobarekar, B.G.1    Vernekar, V.2    Raghavan, V.3    Kamada, M.4    Maegawa, M.5    Bandivdekar, A.H.6
  • 36
    • 37849052991 scopus 로고    scopus 로고
    • Immunocontraceptive effect of Izumo and enhancement by combination vaccination
    • Naz RK: Immunocontraceptive effect of Izumo and enhancement by combination vaccination. Mol Reprod Dev 2008; 75:336-344.
    • (2008) Mol Reprod Dev , vol.75 , pp. 336-344
    • Naz, R.K.1
  • 38
    • 0036249772 scopus 로고    scopus 로고
    • Immunization of female cynomolgus macaques with a synthetic epitope of sperm-specific lactate dehyrogenase results in high antibody titers but does not reduce fertility
    • Tollner TL, Overstreet JW, Branciforte D, Primakoff PD: Immunization of female cynomolgus macaques with a synthetic epitope of sperm-specific lactate dehyrogenase results in high antibody titers but does not reduce fertility. Mol Reprod Dev 2002; 62:257-264.
    • (2002) Mol Reprod Dev , vol.62 , pp. 257-264
    • Tollner, T.L.1    Overstreet, J.W.2    Branciforte, D.3    Primakoff, P.D.4
  • 39
    • 0025294465 scopus 로고
    • Antibodies to sperm surface fertilization antigen (FA-1): their specificities and site of interaction with sperm in male genital tract
    • Naz RK, Bhargava KK: Antibodies to sperm surface fertilization antigen (FA-1): their specificities and site of interaction with sperm in male genital tract. Mol Reprod Dev 1990; 26:175-183.
    • (1990) Mol Reprod Dev , vol.26 , pp. 175-183
    • Naz, R.K.1    Bhargava, K.K.2
  • 42
    • 0028305720 scopus 로고
    • Antisperm antibodies: origin, regulation, and sperm reactivity in human infertility
    • Naz RK, Menge AC: Antisperm antibodies: origin, regulation, and sperm reactivity in human infertility. Fertil Steril 1994; 61:1001-1013.
    • (1994) Fertil Steril , vol.61 , pp. 1001-1013
    • Naz, R.K.1    Menge, A.C.2
  • 43
    • 0031968159 scopus 로고    scopus 로고
    • Mucosal immunity in the female reproductive tract: correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation
    • Kutteh WH, Moldovenanu Z, Mestecky J: Mucosal immunity in the female reproductive tract: correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation. AIDS Res Hum Retroviruses 1998; 14(Suppl 1):S51-S55.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , Issue.SUPPL. 1
    • Kutteh, W.H.1    Moldovenanu, Z.2    Mestecky, J.3
  • 44
    • 23344449309 scopus 로고    scopus 로고
    • Mucosal immunoglobulins
    • Woof JM, Mestecky J: Mucosal immunoglobulins. Immunol Rev 2005; 206:64-82.
    • (2005) Immunol Rev , vol.206 , pp. 64-82
    • Woof, J.M.1    Mestecky, J.2
  • 45
    • 17444394873 scopus 로고    scopus 로고
    • Immunologic uniqueness of the genital tract: challenge for vaccine development
    • Mestecky J, Moldoveanu Z, Russell MW: Immunologic uniqueness of the genital tract: challenge for vaccine development. Am J Reprod Immunol 2005; 53:208-214.
    • (2005) Am J Reprod Immunol , vol.53 , pp. 208-214
    • Mestecky, J.1    Moldoveanu, Z.2    Russell, M.W.3
  • 46
    • 0037388738 scopus 로고    scopus 로고
    • DNA vaccines: a review
    • Liu MA: DNA vaccines: a review. J Intern Med 2003; 253:402-410.
    • (2003) J Intern Med , vol.253 , pp. 402-410
    • Liu, M.A.1
  • 47
    • 0034070945 scopus 로고    scopus 로고
    • Expression of alpha and gamma interferon receptors in the sperm cell
    • Naz RK, Chauhan SC, Rose LP: Expression of alpha and gamma interferon receptors in the sperm cell. Mol Reprod Dev 2000; 56:189-197.
    • (2000) Mol Reprod Dev , vol.56 , pp. 189-197
    • Naz, R.K.1    Chauhan, S.C.2    Rose, L.P.3
  • 48
    • 33744769758 scopus 로고    scopus 로고
    • Effect of sperm DNA vaccine on fertility of female mice
    • Naz RK: Effect of sperm DNA vaccine on fertility of female mice. Mol Reprod Dev 2006; 73:918-928.
    • (2006) Mol Reprod Dev , vol.73 , pp. 918-928
    • Naz, R.K.1
  • 49
    • 33748856179 scopus 로고    scopus 로고
    • Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice
    • Naz RK: Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice. Mol Reprod Dev 2006; 73:1473-1479.
    • (2006) Mol Reprod Dev , vol.73 , pp. 1473-1479
    • Naz, R.K.1
  • 51
    • 16444371299 scopus 로고    scopus 로고
    • Passive immunization for immunocontraception: lessons learned from infectious diseases
    • Naz RK, Changanamkandath R: Passive immunization for immunocontraception: lessons learned from infectious diseases. Front BioSci 2004; 9:2457-2465.
    • (2004) Front BioSci , vol.9 , pp. 2457-2465
    • Naz, R.K.1    Changanamkandath, R.2
  • 52
    • 44449112280 scopus 로고    scopus 로고
    • Isolation of human single chain variable fragment antibodies against specific sperm antigens for immunocontraceptive development
    • Samuel AS, Naz RK: Isolation of human single chain variable fragment antibodies against specific sperm antigens for immunocontraceptive development. Hum Reprod 2008; 23:1324-1337.
    • (2008) Hum Reprod , vol.23 , pp. 1324-1337
    • Samuel, A.S.1    Naz, R.K.2
  • 53
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger P, Hudson PJ: Engineered antibody fragments and the rise of single domains. Nat Biotechnol 2005; 23:1126-1136.
    • (2005) Nat Biotechnol , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 54
    • 36849087921 scopus 로고    scopus 로고
    • The growth and potential of human antiviral monoclonal antibody therapeutics
    • Marasco WA, Sui J: The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol 2007; 25:1421-1434.
    • (2007) Nat Biotechnol , vol.25 , pp. 1421-1434
    • Marasco, W.A.1    Sui, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.