Isolation of human single chain variable fragment antibodies against specific sperm antigens for immunocontraceptive development

Human Reproduction

Volumn 23, Issue 6, 2008, Pages 1324-1337

  Samuel, A S ^a   Naz, R K ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Antisperm antibodies; Immunocontraception; Infertility; Single chain variable fragment antibodies; Sperm antigens

Indexed keywords

AFA 1 ANTIBODY; AS16 ANTIBODY; CELL PROTEIN; COMPLEMENTARY DNA; EPITOPE; FAB 7 ANTIBODY; FERTILIZATION ANTIGEN 1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PLASMID VECTOR; RASA ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SPERM ANTIBODY; SPERM ANTIGEN; TYROSYLLEUCYLPROLYLVALYLGLYCYLGLYCYLLEUCYLARGINYLARGINYLISOLEUCYL GLYCYLGLYCINE;

ACROSOME; ANTIBODY ISOLATION; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ANTIGEN SPECIFICITY; ARTICLE; CELL FUNCTION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG EFFECT; DRUG PURIFICATION; DRUG SPECIFICITY; GENE AMPLIFICATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOCONTRACEPTION; IMMUNOREACTIVITY; IN VITRO STUDY; INHIBITION KINETICS; LEUKOCYTE; MALE; MALE INFERTILITY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; POLYMERASE CHAIN REACTION; PROTEIN INTERACTION; PURIFICATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPERM; SPERMATOZOON CAPACITATION; VASECTOMY;

EID: 44449112280     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/den088     Document Type: Article

References (46)

1. Arndt KM, Muller KM, Pluckthun A. Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment. Biochemistry 1998;37:12918-12926.
2. Bohring C, Krause W. Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis. Hum Reprod 2003;18:915-924.
3. Byrd W, Tsu J, Wolf D. Kinetics of spontaneous and induced acrosomal loss in human sperm incubated under capacitating and noncapacitating conditions. Gamete Res 1989;22:109-122.
4. Casadevall A. Passive antibody therapies: progress and continuing challenges. Clin Immunol 1999;93:5-15.
5. Chapman AP. PEGylated antibodies and antibody fragments for improved therapy: a review. Adv Drug Deliv Rev 2002;54:531-545.
6. Clayton R, Moore H. Experimental models to investigate the pathology of antisperm antibodies: approaches and problems. Hum Reprod 2001;7:457-459.
7. Clayton R, Cooke ID, Partridge LJ, Moore HD. A combinatorial phage display for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro. Biol Reprod 1998;59:1180-1186.
8. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995;16:237-242.
9. Deng XK, Nesbit LA, Morrow KJ. Recombinant single-chain variable fragment antibodies directed against Clostridium difficile toxin B produced by use of an optimized phage display system. Clin Diagn Lab Immunol 2003;10:587-595.
10. Diekman AB, Westbrook-Case VA, Naaby-Hansen S, Klotz KL, Flickinger CJ, Herr JC. Biochemical characterization of sperm agglutination antigen-1, a human sperm specific antigen implicated in gamete interactions. Biol Reprod 1997;57:1136-1144.
11. Dunman PM, Nesin M. Passive immunization as prophylaxis: When and where will this work? Curr Opin Pharmacol 2003;3:486-496.
12. Hamilton S, Odili J, Gundogdu O, Wilson GD, Kupsch JM. Improved production by domain inversion of single-chain Fv antibody fragment against high molecular weight proteoglycan for the radioimmunotargeting of melanoma. Hybrid Hybridomics 2001;20:351-360.
13. Henshaw SK. Unintended pregnancy in the United States. Fam Plann Perspect 1998;30:24-29.
14. Hudson PJ, Kortt AA. High avidity scFv multimers; diabodies and triabodies. J Immunol Methods 1999;231:177-189.
15. Isojima S, Kameda K, Tsuji Y, Shigeta M, Ikeda Y, Koyama K. Establishment and characterization of a human hybridoma secreting monoclonal antibody with high titers of sperm immobilizing and agglutinating activities against human seminal plasma. J Reprod Immunol 1987;10:67-78.
16. Kabat EA, Wu TT, Perry HM, Gottesmann KS, Foeller C. Sequences of Proteins of Immunological Interest, 5th edn. Bethesda, Maryland: National Center for Biotechnology Information, National Library of Medicine, 1991.
17. Koren E, Zuckerman LA, Mire-Sluis AR. Immune responses to therapeutic proteins in humans-clinical significance, assessment and prediction. Curr Pharm Biotechnol 2002;3:349-360.
18. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
19. Mirick GR, Bradt BM, Denardo SJ, Denardo GL. A review of human anti-globulin antibody (HAGA, HAMA, HACA, HAHA) responses to monoclonal antibodies. Not four letter words. Q J Nucl Med Mol Imaging 2004;48:251-257.
20. 12 synthetic peptide in sera and seminal plasma of immunoinfertile men. Mol Hum Reprod 2001;7:21-26.
21. Naz RK, Chauhan SC. Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 2002;67:674-680.
22. Naz RK, Zhu X. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA 1997;94:4704-4709.
23. Naz RK, Zhu X. Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. Biol Reprod 1998;59:1095-1100.
24. Naz RK, Zhu X. Molecular cloning and sequencing of cDNA encoding for human FA-1 antigen. Mol Reprod Dev 2002;63:256-268.
25. Naz RK, Ahmad K, Menge AC. Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies. J Clin Invest 1993;92:2331-2338.
26. Naz RK, Gupta SK, Gupta JC, Vyas HK, Talwar GP. Recent advances in contraceptive vaccine development: a mini-review. Hum Reprod Update 2005;20:3271-3283.
27. Naz RK, Zhu X, Kadam AL. Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol Reprod 2000;62:318-324.
28. Nieba L, Honegger A, Krebber C, Plückthun A. Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment. Protein Eng 1997;10:435-444.
29. Norton EJ, Diekman AB, Westbrook VA, Flickinger CJ, Herr JC. RASA, a recombinant single-chain variable fragment (scFv) antibody directed against the human sperm surface: implications for novel contraceptives. Hum Reprod 2001;16:1854-1860.
30. Ohl DA, Naz RK. Infertility due to antisperm antibodies. Urology 1995;46:591-602.
31. Park KJ, Lee SH, Kim TI, Lee HW, Lee CH, Kim EH, Jang JY, Choi KS, Kwon MH, Kim YS. A human ScFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. Cancer Res 2007;67:7327-7334.
32. Pillai S, Wright D, Gupta A, Zhou G, Hull G, Jiang H, Zhang H. Molecular weights and isoelectric points of sperm antigens relevant to autoimmune infertility in men. J Urol 1996;155:1928-1933.
33. Rader C, Barbas CF, III. Phage display of combinatorial antibody libraries. Curr Opin Biotechnol 1997;8:503-508.
34. Riethmüller G, Schneider-Gädicke E, Johnson JP. Monoclonal antibodies in cancer therapy. Curr Opin Immunol 1993;5:732-739.
35. Sidhu SS, Fellouse FA. Synthetic therapeutic antibodies. Nat Chem Biol 2006;2:682-688.
36. Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 1985;288:1315- 1317.
37. Smith BJ, Popplewell A, Athwal D, Chapman AP, Heywood S, West SM, Carrington B, Nesbitt A, Lawson AD, Antoniw P et al. Prolonged in vivo residence times of antibody fragments associated with albumin. Bioconjug Chem 2001;12:750-756.
38. Svennerholm L, Fredman P. A procedure for the quantitative isolation of brain gangliosides. Biochim Biophys Acta 1980;617:97-109.
39. Talwar GP. Vaccines and passive immunological approaches for the control of fertility and hormone-dependent cancers. Immunol Rev 1999;171:173-192.
40. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
41. Williams J, Samuel A, Naz RK. Presence of antisperm antibodies reactive with peptide epitopes of FA-1 and YLP12 in sera of immunoinfertile women. Am J Reprod Immunol, in press.
42. World POPClock Projection. US Census Bureau [online]. http://www.census.gov/ipc/www/popclockworld.html (13 February 2008, date last accessed).
43. Ye Z, Hellstrom I, Hayden-Ledbetter M, Dahlin A, Ledbetter JA, Hellstrom KE. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat Med 2002;8:343-348.
44. Yokota T, Milenic DE, Whitlow M, Schlom J. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 1992;52:3402-3408.
45. Zhang W, Matsumoto-Takasaki A, Kusada Y, Sakaue H, Sakai K, Nakata M, Fujita-Yamaguchi Y. Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 2. Expression, purification, and characterization of recombinant single chain antibodies. Biochemistry 2007;46:263-270.
46. Zhou Y, Drummond DC, Zou H, Hayes ME, Adams GP, Kirpotin DB, Marks JD. Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor expressing tumor cells. J Mol Biol 2007;371:934-947.