Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice

Molecular Reproduction and Development

Volumn 73, Issue 11, 2006, Pages 1473-1479

  Naz, Rajesh K ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Contraceptive vaccine; DNA vaccine; Fertility; Immunocontraception; Sperm

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; FERTILIZATION ANTIGEN 1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; PEPTIDE; PLASMID VECTOR; RECOMBINANT ANTIGEN; TYROSYLLEUCYLPROLYLVALYLGLYCYLGLYCYLLEUCYLARGINYLARGINYLISOLEUCYLGLYCYLGLYC INE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BIOLISTIC TRANSFORMATION; CONTRACEPTION; CONTROLLED STUDY; DRUG FORMULATION; EXPRESSION VECTOR; FEMALE; FEMALE FERTILITY; FEMALE GENITAL SYSTEM; GENE GUN; GENETIC TRANSDUCTION; IMMUNE RESPONSE; IMMUNOCONTRACEPTION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; OBSERVATION; OBSERVATION PERIOD; PRIORITY JOURNAL; SPERM; TIME; VACCINATION; VAGINAL TRACT;

ANIMALS; ANTIGENS; CONTRACEPTION; FEMALE; FERTILITY; MICE; MICE, INBRED STRAINS; VACCINES, CONTRACEPTIVE; VACCINES, DNA;

EID: 33748856179     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20591     Document Type: Article

References (27)

1. Ada G, Ramshaw I. 2003. DNA vaccination. Expert Opin Emerg Drugs 8:27-35.
2. Berzofsky JA, Ahlers JD, Belyakov IM. 2001. Strategies for designing and optimizing new generation vaccines. Nature Rev Immunol 1:209-219.
3. Gurunathan S, Klinman DM, Seder RA. 2000. DNA vaccines: Immunology, application, and optimization. Annu Rev Immunol 18:927-974.
4. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. 2000. A toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
5. Kaplan P, Naz RK. 1992. The fertilization antigen-1 does not have any proteolytic/acrosin activity, but its monoclonal antibody inhibits sperm capacitation and acrosome reaction. Fertil Steril 58:396-402.
6. Klinman DM, Yamshchikov G, Ishigatsubo Y. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 158:3635-3639.
7. Kozak M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNA's. Nuc Acids Res 15:8125-8148.
8. Kozak M. 1991. An analysis of vertebrate mRNA sequences: Intimations of translational control. J Cell Biol 115:887-903.
9. Laylor R, Porakishvili N, De Souza JB, Playfair JH, Delves PJ, Lund T. 1999. DNA vaccine favours memory rather than effector B cell response. Clin Exp Immunol 117:106-112.
10. Leitner WW, Thalhamer J. 2003. DNA vaccines for non-infectious diseases: New treatments for tumor and allergy. Expert Opin Biol Ther 3:627-638.
11. Lowrie DB. 2003. DNA vaccination: An update. Methods Mol Med 87:377-390.
12. Moldoveanu Z, Love-Homan L, Huang W, Krieg A. 1998. CpG DNA, a novel immune inhancer for systematic and mucosal immunization with influenza virus. Vaccine 16:1216-1224.
13. Naz RK. 1999. Involvement of protein serine and threonine phosphorylation in human sperm capacitation. Biol Reprod 60:1402-1409.
14. Naz RK. 2006. Effect of sperm DNA vaccine on fertility of female mice. Mol Reprod Dev 73:918-928.
15. Naz RK, Chauhan SC. 2002. Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 67:674-680.
16. Naz RK, Zhu X. 1998. Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. Biol Reprod 59:1095-1100.
17. Naz RK, Zhu X. 2002. Molecular cloning and sequencing of cDNA encoding for human FA-1 antigen. Mol Reprod Dev 63:256-268.
18. Naz RK, Phillips TM, Rosenblum B. 1986. Characterization of the fertilization antigen 1 for the development of a contraceptive vaccine. Proc Natl Acad Sci USA 83:5713-5717.
19. Naz RK, Ahmad K, Menge A. 1993. Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies. J Clin Invest 92:2331-2338.
20. Naz RK, Zhu X, Kadam AL. 2000. Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol Reprod 62:318-324.
21. Pardoll DM. 2002. Spinning molecular immunology into successful immunotherapy. Nature Rev Immunol 2:227-238.
22. Prud'homme GJ. 2004. DNA vaccination against tumors. J Gene Med 7:3-17.
23. Robinson HL. 1999. DNA vaccines: Basic mechanism and immune responses. Int J Mol Med 4:549-555.
24. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M, Silverman MD, Lotz GJ, Carson M, Raz DA. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352-354.
25. Shoda LK, Kegerreis KA, Suarez CE, Mwangi W, Knowels DP, Brown WC. 2001. Immunostimulatory CpG-modified plasmid DNA enhances IL-12, TNF-alpha, and NO production by bovine macrophages. J Leuko Biol 70:103-112.
26. Weiner G, Liu H, Wooldridge J, Dahle C, Krieg A. 1997. Immunostimulatory obligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 94:10833-10837.
27. Zhu X, Naz RK. 1997. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA 94:4704-4709.