Human sperm-specific peptide vaccine that causes long-term reversible contraception

Biology of Reproduction

Volumn 67, Issue 2, 2002, Pages 674-680

  Naz, Rajesh K ^a   Chauhan, Subhash C ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Acrosome reaction; Immunology; Male reproductive tract; Sperm; Testis

Indexed keywords

CHOLERA TOXIN; CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG; VACCINE; YLP 12; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; OLIGOPEPTIDE; PEPTIDE; RECOMBINANT PROTEIN; YLP(12) PROTEIN, HUMAN;

ACROSOME REACTION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FERTILITY; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SPERMATOZOON CAPACITATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOELECTRON MICROSCOPY; IMMUNOLOGY; MALE; METHODOLOGY; SPERMATOZOON; VACCINATION; WESTERN BLOTTING;

ANIMALIA; MURINAE;

ACROSOME REACTION; ADJUVANTS, IMMUNOLOGIC; ANIMALS; BLOTTING, WESTERN; CHOLERA TOXIN; CONTRACEPTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MALE; MICE; MICROSCOPY, IMMUNOELECTRON; OLIGOPEPTIDES; PEPTIDES; RECOMBINANT PROTEINS; SPERM-OVUM INTERACTIONS; SPERMATOZOA; VACCINATION; VACCINES;

EID: 0035992913     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod67.2.674     Document Type: Article

References (28)

1. Development of contraceptive vaccines for humans using antigens derived from gametes and hormones: Current status
2. Temporary sterilization by injection of human spermatozoa: A preliminary report
3. Immunological control of fertility in female mice
4. Immune reactions and infertility
5. Sperm antibodies: Their role in infertility
6. Sperm antibodies and autoantibodies: Effects on fertility
7. Infertility due to antisperm antibodies
8. Vaccine for contraception targeting sperm
9. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20
10. A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice
11. Examination of the immunocontraceptive potential of recombinant rabbit fertilin subunits in rabbit
12. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects
13. Identification of human sperm peptide sequence involved in egg binding for immunocontraception
14. 12 synthetic peptide in sera and seminal plasma of immunoinfertile men
15. Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response
16. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit
17. Induction of mucosal and systemic immune responses by intranasal immunization using recombinant cholera toxin B subunit as an adjuvant
18. Involvement of fertilization antigen (FA-1) in involuntary immunoinfertility in humans
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
21. Correlation of pinopod development on uterine luminal epithelial surface with hormonal events and endometrial sensitivity in rat
22. Fertilization antigen-1 removes antisperm antibodies from spermatozoa of infertile men and results in increased rates of acrosome reaction
23. Kinetics of spontaneous and induced acrosomal loss in human sperm incubated under capacitating and noncapacitating conditions
24. Biochemical characterization of a glycosylphosphatidylinositol-linked hyaluronidase on mouse sperm
25. Monoclonal antibody to a human sperm membrane glycoprotein that inhibits fertilization
26. Temporal changes in motility parameters related to acrosomal status: Identification and characterization of populations of hyperactivated human sperm
27. Human sperm motility after migration into and incubation in synthetic media
28. 12 peptide sequence involved in oocyte binding