Effect of sperm DNA vaccine on fertility of female mice

Molecular Reproduction and Development

Volumn 73, Issue 7, 2006, Pages 918-928

  Naz, Rajesh K ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Contraceptive vaccine; DNA vaccine; Immunocontraception; Infertility; Sperm

Indexed keywords

COMPLEMENTARY DNA; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; DNA; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; FEMALE; FEMALE FERTILITY; GENE EXPRESSION; GENE GUN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOCONTRACEPTION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERM; T LYMPHOCYTE; TH1 CELL; TH2 CELL; VACCINATION; VAGINA;

ANIMALS; ANTIBODIES; BIOLISTICS; CONTRACEPTION, IMMUNOLOGIC; CPG ISLANDS; FEMALE; IMMUNIZATION, SECONDARY; MALE; MICE; OLIGOPEPTIDES; SPERMATOZOA; TH1 CELLS; VACCINES, CONTRACEPTIVE; VACCINES, DNA; VAGINA;

ANIMALIA;

EID: 33744769758     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20487     Document Type: Article

References (40)

1. Ailiang Z, Huali J, Fuchun Z, Zhenghai M, Yixian T, Zhihui R, Xinyu Z, Kaichun Z, Wang B. 2005. Effects of multiple copies of CpG on DNA vaccination. DNA Cell Biol 24:292-298.
2. Baskin MJ. 1932. Temporary sterilization by injection of human spermatozoa: A preliminary report. Am J Obstet Gynecol 24:892-897.
3. Bronson RA, Cooper GW, Rosenfeld DL. 1984. Sperm antibodies: Their role in infertility. Fertil Steril 42:171-182.
4. Byrd W, Tsu J, Wolf D. 1989. Kinetics of spontaneous and induced acrosomal loss in human sperm incubated under capacitating and noncapacitating conditions. Gamete Res 22:109-122.
5. Davis H, Weeranta R, Waldschmidt T. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 160:870-876.
6. Edwards RG. 1964. Immunological control of fertility in female mice. Nature 203:50-53.
7. Hardy CM, Clark HD, Nixon B, Grigg JA, Hinds LA, Holland MK. 1997. Examination of the immunocontraceptive potential of recombinant rabbit fertilin subunits in rabbit. Biol Reprod 57:879-886.
8. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. 2000. A toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
9. Henshaw SK. 1998. Unintended pregnancy in the United States. Fam Plan Perspect 30:24-29.
10. Herr JC, Flickinger CJ, Homyk M. 1990. Biochemical and morphological characterization of intra-acrosomal antigen SP-10 from human sperm. Biol Reprod 42:181-189.
11. Ishii KJ, Gursel I, Gursel M, Klinman DM. 2004. Immunotherapeutic itility of stimulatory and suppressive oligodeoxynucleotides. Curr Opin Mol Ther 6:166-174.
12. Klinman DM, Yamshchikov G, Ishigatsubo Y. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 158:3635-3639.
13. Kozak M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNA's. Nuc Acids Res 15:8125-8148.
14. Kozak M. 1991. An analysis of vertebrate mRNA sequences: Intimations of translational control. J Cell Biol 115:887-903.
15. Laylor R, Porakishvili N, De Souza JB, Playfair JHL, Delves PJ, Lund T. 1999. DNA vaccination favours memory rather than effector B cell response. Clin Exp Immunol 117:106-112.
16. Lea IA, Lierop MJ, Widgren EE, Grootenhuis A, Wen Y, van Duin M, O'Rand MG. 1998. A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice. Biol Reprod 59:527-536.
17. Liu MA. 2003. DNA vaccines: A review. J Intern Med 253:402-410.
18. Menge AC. 1970. Immune reactions and infertility. J Reprod Fertil 10:171-185.
19. Moldoveanu Z, Love-Homan L, Huang W, Krieg A. 1998. CpG DNA, a novel immune enhancer for systematic and mucosal immunization with influenza virus. Vaccine 16:1216-1224.
20. Naz RK. 2005. Contraceptive vaccines. Drugs 65:593-601.
21. 12 synthetic peptide in sera and seminal plasma of immunoinfertile men. Mol Hum Reprod 7:21-26.
22. Naz RK, Chauhan SC. 2002. Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod 67:674-680.
23. 1 enhances expression of 50 kDa protein related to 2′-5′ oligoadenylate synthetase in human sperm cells. J Cell Physiol 146:156-163.
24. Naz RK, Mehta K. 1989. Cell-mediated immune responses to sperm antigens: Effects on mouse sperm and embryos. Biol Reprod 41:533-542.
25. Naz RK, Chauhan SC, Rose LP. 2000a. Expression of alpha and gamma interferon receptors in the sperm cell. Mol Reprod Dev 56:189-197.
26. Naz RK, Zhu X, Kadam AL. 2000b. Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol Reprod 62:318-324.
27. Naz RK, Zhu X, Kadam AL. 2001. Cloning and sequencing of cDNA encoding for a novel human testis-specific contraceptive vaccinogen: Role in immunocontraception. Mol Reprod Dev 60:116-127.
28. Naz RK, Gupta SK, Gupta JC, Vyas HK, Talwar GP. 2005. Recent advances in contraceptive vaccine development. Hum Reprod 20:3271-3283.
29. O'Rand MG, Widgren EE, Sivashanmugam P, Richardson RT, Hall SH, French FS, VandeVoort CA, Ramachandra SG, Ramesh V, Jagannadha Rao A. 2004. Reversible immunocontraception in male monkeys immunized with Eppin. Science 306:1189-1190.
30. Patil SD, Rhodes DG, Burgess DJ. 2005. DNA-based therapeutics and DNA delivery systems: A comprehensive review. AAPS J 7:E61-E77.
31. Pontarollo RA, Babiuk LA, Hecker R, Drunen Little-Van Den Hurk S. 2002. Augmentation of cellular immune responses to bovine herpesvirus-1 glycoprotein D by vaccination with CpG-enhanced plasmid vectors. J Gen Virol 83:2973-2981.
32. Primakoff P, Lathrop W, Wollman L, Cowan A, Myles D. 1988. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 335:543-547.
33. Robinson HL. 1999. DNA vaccines: Basic mechanism and immune responses. Int J Mol Med 4:549-555.
34. Santhanam R, Naz RK. 2001. Novel human testis-specific cDNA: Molecular cloning, expression and immunobiological effects of the recombinant protein. Mol Reprod Dev 60:1-12.
35. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M, Silverman MD, Lotz GJ, Carson M, Raz DA. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352-354.
36. Shoda LK, Kegerreis KA, Suarez CE, Mwangi W, Knowles DP, Brown WC. 2001. Immunostimulatory CpG-modified plasmid DNA enhances IL-12, TNF-alpha, and NO production by bovine macrophages. J Leuko Biol 70:103-112.
37. Weeranta RD, McCluskie MJ, Comanita L, Wu T, Davis HL. 2000. Optimization strategies for DNA vaccines. Intervirology 43:218-226.
38. Weiner G, Liu H, Wooldridge J, Dahle C, Krieg A. 1997. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 94:10833-10837.
39. Whalen RG. 1996. DNA vaccines for emerging infectious diseases: What if? Emerg Infect Dis 2:168-175.
40. Zhu X, Naz RK. 1997. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA 94:4704-4709.