Identification of human sperm peptide sequence involved in egg binding for immunocontraception

Biology of Reproduction

Volumn 62, Issue 2, 2000, Pages 318-324

  Naz, Rajesh K ^a   Zhu, Xiaolong ^a   Kadam, Arjun L ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b New York Fertility Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACEPTIVE AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; SPERM ANTIGEN; VACCINE;

ACROSOME; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILIZATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCONTRACEPTION; IMMUNOPRECIPITATION; MALE; PEPTIDE ANALYSIS; PHAGE DISPLAY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; ZONA PELLUCIDA;

EID: 0033959872     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod62.2.318     Document Type: Article

References (35)

1. Naz RK, Sacco A, Singh O, Pal R, Talwar GP. Development of contraceptive vaccines for humans using antigens derived from gametes (spermatozoa and zona pellucida) and hormones (human chorionic gonadotropin): current status. Hum Reprod 1995; 1:1-18.
2. Naz RK, Vaneck CM. Testis-specific proteins and their role in contraceptive vaccine development. Front Biosci 1998; 3:39-48.
3. Edwards RG. Immunological control of fertility of female mice. Nature 1964; 203:50-53.
4. Menge AC. Immune reactions and infertility. J Reprod Fertil Suppl 1970; 10:171-185.
5. Allardyce RA. Effect of ingested sperm on fecundity in the rat. J Exp Med 1984; 159:1548-1553.
6. Baskin MJ. Temporary sterilization by injection of human spermatozoa: a preliminary report. Am J Obstet Gynecol 1932; 24:892-897.
7. Mancini RE, Andrada JA, Saraceni D, Bachman AE, Lavier JD, Nemirovsky M. Immunological and testicular response in men sensitized with human testicular homogenate. J Clin Endocrinol Metab 1965; 25:859-875.
8. Naz R, Menge AC. Antisperm antibodies: origin, regulation, and sperm reactivity in human infertility. Fertil Steril 1994; 61:1001-1013.
9. Liskin L, Pile JM, Quillan WF. Vasectomy-safe and simple. Popul Rep 1983; 4:61-100.
10. Naz RK, Deutsch J, Phillips TM, Menge AC, Fisch H. Sperm antibodies in vasectomized men and their effects on fertilization. Biol Reprod 1989; 40:163-173.
11. Ohl DA, Naz RK. Infertility due to antisperm antibodies. Urology 1995; 46:591-602.
12. Schulman S. Sperm antibodies and autoantibodies: effects on fertility. Am J Reprod Immunol Microbiol 1986; 10:86-89.
13. Primakoff P, Lathrop W, Wollman L, Cowan A, Myles D. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 1988; 335:543-547.
14. Sirinivasan S, Tinge R, Wright JC, Herr J, Curtiss III R. Oral immunization with attenuated Salmonella expressing human sperm antigen induces antibodies in serum and the reproductive tract. Biol Reprod 1995; 53:462-471.
15. Hardy CM, Clarke HG, Nixon B, Grigg JA, Hinds LA, Holland MK. Examination of the immunocontraceptive potential of recombinant rabbit fertilin subunits in rabbit. Biol Reprod 1997; 57:879-886.
16. Naz RK, Zhu X. Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. Biol Reprod 1998; 59: 1095-1100.
17. Yanagimachi R. Mammalian fertilization. In: Knobil E, Neill JD (eds.), The Physiology of Reproduction. New York: Raven Press; 1994: 189-318.
18. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-685.
19. Towbin H, Stachelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76:4350-4354.
20. Zhu X, Naz RK. Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA 1997; 94:4704-4709.
21. Naz RK, Ahmad K. Molecular identities of human sperm proteins that bind human zona pellucida: nature of sperm-zona interaction, tyrosine kinase activity, and involvement of FA-1. Mol Reprod Dev 1994; 39: 397-408.
22. Naz RK, Zhu X, Menge AC. Expression of tumor necrosis factor-α and its receptors type I and type II in human oocytes. Mol Reprod Dev 1997; 47:127-133.
23. Naz RK. Effects of antisperm antibodies on early cleavage of fertilized ova. Biol Reprod 1992; 46:130-139.
24. Pearson WP, Lipman DJ. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 1988; 85:2444-2448.
25. Tsong YY, Chang CC, Nash HA. Formulation of a potential antipregnancy vaccine based on the β-subunit of human chorionic gonadotropin (β-hCG). J Reprod Immunol 1985; 7:139-149.
26. Nisonoff A, Wissler FC, Lipman LN, Woernley DL. Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds. Arch Biochem Biophys 1960; 89:230-244.
27. Naz RK, Ahmad K, Menge AC. Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies. J Clin Invest 1993; 92:2331-2338.
28. Kadam AL, Fateh M, Naz RK. Fertilization antigen (FA-1) completely blocks human sperm binding to human sperm zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. J Reprod Immunol 1995; 29:19-30.
29. Naz RK, Phillips TM, Rosenblum BB. Characterization of the fertilization antigen 1 for the development of a contraceptive vaccine. Proc Natl Acad Sci USA 1986; 83:5713-5717.
30. Naz RK, Morte C, Ahmad K, Martinez P. Hexokinase present in human sperm is not tyrosine phosphorylated but its antibodies affect fertilizing capacity. J Androl 1996; 17:143-150.
31. Naz RK, Ahmad K, Kaplan P. Expression and function of ras protooncogene proteins in human sperm cells. J Cell Sci 1992; 102:487-494.
32. Chamberlin ME, Dean J. Human homolog of the mouse sperm receptor. Proc Natl Acad Sci USA 1990; 87:6014-6018.
33. Millar SE, Dean J. Targeting the zona pellucida for immunocontraception. In: Naz RK (ed.), Immunology of Reproduction. Boca Raton: CRC Press; 1993: 37-60.
34. Shabanowitz RB. Mouse antibodies to human zona pellucida: evidence that human ZP3 is strongly immunogenic and contains two district isomer chains. Biol Reprod 1990; 43:260-270.
35. Zara J, Naz RK. The role of carbohydrates in mammalian sperm-egg interactions: how important are carbohydrate epitopes? Front Biosci 1998; 3:1028-1038.