Colinear synthesis of an antigen-specific B-cell epitope with a 'promiscuous' tetanus toxin T-cell epitope: A synthetic peptide immunocontraceptive

Vaccine

Volumn 15, Issue 16, 1997, Pages 1761-1766

  O'Hern, Patricia A ^a   Liang, Zhi Guo ^a   Bambra, Charanjit S ^b   Goldberg, Erwin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b National Museums of Kenya   (Japan)

Author keywords

Immunocontraceptive; Lactate dehydrogenase; T cell epitope

Indexed keywords

EPITOPE; SYNTHETIC PEPTIDE; TETANUS TOXIN; VACCINE;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; BABOON; CONTROLLED STUDY; FERTILITY; IMMUNIZATION; IMMUNOCONTRACEPTION; IMMUNOGENICITY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RABBIT;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; CONTRACEPTION, IMMUNOLOGIC; EPITOPES; FEMALE; HAPLOTYPES; L-LACTATE DEHYDROGENASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOLECULAR SEQUENCE DATA; PAPIO; RABBITS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TETANUS TOXIN; VACCINES, SYNTHETIC;

EID: 0030846202     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00105-9     Document Type: Article

References (18)

1. 4 as an immunocontraceptive model. In Gamete Interaction: Prospects for Immunocontraception (Eds Alexander, N. J., Griffin, D., Spieler, J. M. and Waites, G. M. H.). Wiley-Liss, New York, 1990, pp. 63-73
2. 4. Journal of Biological Chemistry 1987, 262, 13155-13162.
3. 4). Journal of Biological Chemistry 1989, 264, 10513-10519.
4. 4. In Techniques in Protein Chemistry IV (Ed Angelette, R. H.). Academic Press, New York, 1993, pp. 481-490
5. O'Hern, P. A., Bambra, C. S., Isahakia, M. and Goldberg, E. Reversible contraception in female baboons immunized with a synthetic epitope of sperm-specific lactate dehydrogenase. Biology of Reproduction 1995, 52, 331-339.
6. Schutze, M. P., Leclerc, C., Jolivet, M., Audibert, F. and Chedid, L. Carrier-induced epitopic suppression, a major issue for future synthetic vaccines. Journal of Immunology 1985, 135, 2319-2322.
7. Kaliyaperumal, A., Chauhan, V. S., Talwar, G. P. and Raghupathy, R. Carrier-induced epitope-specific regulation and its bypass in a protein-protein conjugate. European Journal of Immunology 1995, 25, 3375-3380.
8. Lee, E. C., Powell, J. E., Tregear, G. W., Niall, H. D. and Stevens, V. C. A method for preparing beta-hCG COOH peptide-carrier conjugates of predictable composition. Molecular Immunology 1980, 17, 749-756.
9. Eldridge, J. H., Staas, J. K., Meulbroek, J. A., McGhee, J. R., Tice, T. R. and Gilley, R. M. Biodegradable microspheres as a vaccine delivery system. Molecular Immunology 1991, 28, 287-294.
10. O'Hagan, D. T., Jeffery, H., Roberts, M. J., McGee, J. P. and Davis, S. S. Controlled release microparticles for vaccine development. Vaccine 1991, 9, 768-771.
11. Ho, P. C., Mutch, D. A., Winkel, K. D., Saul, A. J., Jones, G. L., Doran, T. J. and Rzepczyk, C. M. Identification of two promiscuous T cell epitopes from tetanus toxin. European Journal of Immunology 1990, 20, 477-483.
12. Kaumaya, P. T., Kobs-Conrad, S., Seo, Y. H., Lee, H., VanBuskirk, A. M., Feng, N., Sheridan, J. F. and Stevens, V. Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. Journal of Molecular Recognition 1993, 6, 81-94.
13. LeVan, K. M. and Goldberg, E. Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli. Biochemistry Journal 1991, 273, 587-592.
14. Karr, R. W., Panina-Bordignon, P., Yu, W. Y. and Lanzavecchia, A. Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-CR beta chain substitutions. Journal of Immunology 1991, 146, 4242-4247.
15. Panina-Bordignon, P., Tan, A., Termijtelen, A., Demotz, S., Corradin, G. and Lanzavecchia, A. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. European Journal of Immunology 1989, 19, 2237-2242.
16. Goldberg, E. and O'Hern, P. A. Identification of cDNA clones reactive with sera from infertile patients. In Reproductive Immunology-Serono Symposia Publication from Raven Press (Eds Dondero, F. and Johnson, P. M.). Raven Press, New York, 1993, pp. 35-39
17. Stevens, V. C., Powell, J. E., Rickey, M., Lee, A. C. and Lewis, D. H. Studies of various delivery systems for a human chorionic gonadotropin vaccine. In Gamete Interaction: Prospects for Immunocontraception (Eds Alexander, N. J., Griffin, D., Spieler, J. M. and Waites, G. M.H.). Wiley-Liss, New York, 1990, pp. 549-563
18. Men, Y., Thomasin, C., Merkle, H. P., Gander, B. and Corradin, G. A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminum hydroxide. Vaccine 1995, 13, 683-689.