Rho-kinase inhibitors decrease TGF-β-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts

Biochemical Pharmacology

Volumn 77, Issue 2, 2009, Pages 196-203

  Kuno, Masashi ^a   Takai, Shinji ^a   Matsushima Nishiwaki, Rie ^a   Minamitani, Chiho ^a,b   Mizutani, Jun ^b   Otsuka, Takanobu ^b   Harada, Atsushi ^c   Adachi, Seiji ^a   Kozawa, Osamu ^a   Tokuda, Haruhiko ^a,c  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

MAP kinase; Osteoblast; Rho kinase inhibitor; TGF ; VEGF

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FASUDIL; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN PHOSPHATASE; PHOSPHATASE; PROTEIN P42; PROTEIN P44; RHO KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBUNIT; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SYNTHESIS; WESTERN BLOTTING;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 3T3 CELLS; ANIMALS; ANIMALS, NEWBORN; ENZYME INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MYOSIN-LIGHT-CHAIN KINASE; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; SKULL; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 57249108205     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.10.014     Document Type: Article

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