Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F

Biochimie

Volumn 93, Issue 7, 2011, Pages 1081-1088

  Adachi, Hironori ^a   Ishiguro, Akira ^a   Hamada, Michiaki ^a,b   Sakota, Eri ^b   Asai, Kiyoshi ^a,b   Nakamura, Yoshikazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Cytokine GRO ; IL 17A F heterodimer; Induction; Interleukin 17; RNA aptamer; RNA footprint

Indexed keywords

APTAMER; HETERODIMER; HOMODIMER; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 17F; RIBONUCLEASE; RNA; SINGLE STRANDED DNA;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; NUCLEIC ACID SEQUENCE BASED AMPLIFICATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; RNA CONFORMATION; SURFACE PLASMON RESONANCE;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BINDING, COMPETITIVE; COMPUTER SIMULATION; HUMANS; INTERLEUKIN-17; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, INTERLEUKIN-17; RIBONUCLEASES; SURFACE PLASMON RESONANCE;

MUS;

EID: 79958026711     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.04.003     Document Type: Article

References (40)

1. P. Miossec, T. Korn, V.K. Kuchroo, Interleukin-17 and type 17 helper T cells, N. Engl. J. Med. 361 (2009) 888-898.
2. T. Korn, E. Bettelli, M. Oukka, V.K. Kuchroo, IL-17 and Th17 Cells, Annu. Rev. Immunol. 27 (2009) 485-517.
3. X.O. Yang, R. Nurieva, G.J. Martinez, H.S. Kang, Y. Chung, B.P. Pappu, et al., Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity 29 (2008) 44-56.
4. E. Bettelli, Y. Carrier, W. Gao, T. Korn, T.B. Strom, M. Oukka, et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature 441 (2006) 235-238.
5. G.G. Krueger, R.G. Langley, C. Leonardi, N. Yeilding, C. Guzzo, Y. Wang, et al., A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis, N. Engl. J. Med. 356 (2007) 580-592. (Pubitemid 46220818)
6. M. Chabaud, P. Garnero, J.M. Dayer, P.A. Guerne, F. Fossiez, P. Miossec, Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis, Cytokine 12 (2000) 1092-1099. (Pubitemid 30479493)
7. B.W. Kirkham, M.N. Lassere, J.P. Edmonds, K.M. Juhasz, P.A. Bird, C.S. Lee, et al., Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort), Arthritis Rheum. 54 (2006) 1122-1131.
8. D. Matusevicius, P. Kivisäkk, B. He, N. Kostulas, V. Ozenci, S. Fredrikson, et al., Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis, Mult. Scler. 5 (1999) 101-104.
9. J.J. Graber, S.R. Allie, K.M. Mullen, M.V. Jones, T. Wang, C. Krishnan, et al., Interleukin-17 in transverse myelitis and multiple sclerosis, J. Neuroimmunol. 196 (2008) 124-132.
10. Y. Suzuki, Y. Kuroda, A. Morita, Y. Fujino, Y. Tanioka, T. Kawamura, et al., Fibrin glue sealing for the prevention of pancreatic fistulas following distal pancreatectomy, Arch. Surg. 130 (1995) 952-955.
11. R.H. Duerr, K.D. Taylor, S.R. Brant, J.D. Rioux, M.S. Silverberg, M.J. Daly, et al., A genome-wide association study identifies IL23R as an inflammatory bowel disease gene, Science 314 (2006) 1461-1463. (Pubitemid 44871953)
12. J.A. Emamaullee, J. Davis, S. Merani, C. Toso, J.F. Elliott, A. Thiesen, et al., Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice, Diabetes 58 (2009) 1302-1311.
13. S. Molet, Q. Hamid, F. Davoine, E. Nutku, R. Taha, N. Pagé, et al., IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines, J. Allergy Clin. Immunol. 108 (2001) 430-438.
14. S.H. Chang, C. Dong, A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses, Cell Res. 17 (2007) 435-440. (Pubitemid 46763094)
15. J.F. Wright, F. Bennett, B. Li, J. Brooks, D.P. Luxenberg, M.J. Whitters, et al., The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/ IL-17RC receptor complex, J. Immunol. 181 (2008) 2799-2805.
16. + T cells, J. Biol. Chem. 282 (2007) 13447-13455.
17. S.C. Liang, A.J. Long, F. Bennett, M.J. Whitters, R. Karim, M. Collins, et al., An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment, J. Immunol. 179 (2007) 7791-7799.
18. X.O. Yang, S.H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, et al., Regulation of inflammatory responses by IL-17F, J. Exp. Med. 205 (2008) 1063-1075.
19. S. Schnyder-Candrian, D. Togbe, I. Couillin, I. Mercier, F. Brombacher, V. Quesniaux, et al., Interleukin-17 is a negative regulator of established allergic asthma, J. Exp. Med. 203 (2006) 2715-2725.
20. C. Tuerk, L. Gold, Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science 249 (1990) 505-510.
21. A.D. Ellington, J.W. Szostak, In vitro selection of RNA molecules that bind specific ligands, Nature 346 (1990) 818-822.
22. A. Oguro, T. Ohtsu, Y.V. Svitkin, N. Sonenberg, Y. Nakamura, RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis, RNA 9 (2003) 394-407. (Pubitemid 36356727)
23. S. Miyakawa, A. Oguro, T. Ohtsu, H. Imataka, N. Sonenberg, Y. Nakamura, RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes, RNA 12 (2006) 1825-1834. (Pubitemid 44484256)
24. A.D. Keefe, R.G. Schaub, Aptamers as candidate therapeutics for cardiovascular indications, Curr. Opin. Pharmacol. 8 (2008) 147-152.
25. S. Miyakawa, Y. Nomura, T. Sakamoto, Y. Yamaguchi, K. Kato, S. Yamazaki, et al., Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G, RNA 14 (2008) 1154-1163. (Pubitemid 351717495)
26. D. Huang, D. Vu, L.A. Cassiday, J.M. Zimmerman, L.J. Maher, G. Ghosh, Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer, Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 9268-9273.
27. W.T. Horn, M.A. Convery, N.J. Stonehouse, C.J. Adams, L. Liljas, S.E.V. Phillips, et al., The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: further challenges in the modeling of ligand-RNA interactions, RNA 10 (2004) 1776-1782. (Pubitemid 39426377)
28. S.B. Long, M.B. Long, R.R. White, B.A. Sullenger, Crystal structure of an RNA aptamer bound to thrombin, RNA 14 (2008) 2504-2512.
29. Y. Nomura, S. Sugiyama, T. Sakamoto, S. Miyakawa, H. Adachi, K. Takano, et al., Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex, Nucleic Acids Res. 38 (2010) 7822-7829.
30. R. Stoltenburg, C. Reinemann, B. Strehlitz, SELEXea (r)evolutionary method to generate high-affinity nucleic acid ligands, Biomol. Eng. 24 (2007) 381-403.
31. M.G. Theis, A. Knorre, B. Kellersch, J. Moelleken, F. Wieland, W. Kolanus, et al., Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2, Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11221-11226. (Pubitemid 39038328)
32. R.D. Jenison, S.C. Gill, A. Pardi, B. Polisky, High-resolution molecular discrimination by RNA, Science 263 (1994) 1425-1429. (Pubitemid 24137828)
33. S.D. Seiwert, T. Stines Nahreini, S. Aigner, N.G. Ahn, O.C. Uhlenbeck, RNA aptamers as pathway-specific MAP kinase inhibitors, Chem. Biol. 7 (2000) 833-843.
34. A. Ishiguro, T. Akiyama, H. Adachi, J. Inoue, Y. Nakamura, Therapeutic potential of anti-interleukin-17A aptamer: suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models, Arthritis Rheum. 63 (2011) 455-466.
35. M. Hamada, H. Kiryu, K. Sato, T. Mituyama, K. Asai, Prediction of RNA secondary structure using generalized centroid estimators, Bioinformatics 25 (2009) 465-473.
36. J.S. McCaskill, The equilibrium partition function and base pair binding probabilities for RNA secondary structure, Biopolymers 29 (1990) 1105-1119. (Pubitemid 20145703)
37. M. Andronescu, A. Condon, H.H. Hoos, D.H. Mathews, K.P. Murphy, Computational approaches for RNA energy parameter estimation, RNA 16 (2010) 2304-2318.
38. A. Lindén, M. Adachi, Neutrophilic airway inflammation and IL-17, Allergy 57 (2002) 769-775. (Pubitemid 34969998)
39. J.J. Yu, S.L. Gaffen, Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity, Front. Biosci. 13 (2008) 170-177.
40. T. Shalom-Barak, J. Quach, M. Lotz, Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB, J. Biol. Chem. 273 (1998) 27467-27473.