RNA aptamers as pathway-specific MAP kinase inhibitors

Chemistry and Biology

Volumn 7, Issue 11, 2000, Pages 833-843

  Seiwert, Scott D ^a   Stines Nahreini, Theresa ^a   Aigner, Stefan ^a   Ahn, Natalie G ^a   Uhlenbeck, Olke C ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Inhibitor; Kinase; Kinetics; Mitogen activated protein kinase; RNA aptamer; RNA selection

Indexed keywords

ENZYME INHIBITOR; ENZYME REGULATION; EUKARYOTIC CELL; IN VITRO CULTURE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHORYLATION; RNA; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; GENE LIBRARY; GENES, REPORTER; HUMANS; KINETICS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PHOSPHORYLATION; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; RNA; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 0033764406     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00032-6     Document Type: Article

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