RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes

RNA

Volumn 12, Issue 10, 2006, Pages 1825-1834

  Miyakawa, Shin ^a   Oguro, Akihiro ^a   Ohtsu, Takashi ^a   Imataka, Hiroaki ^b   Sonenberg, Nahum ^c   Nakamura, Yoshikazu ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN   (Japan)

^c MCGILL UNIVERSITY   (Canada)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cap dependent translation; eIF4G; Initiation factor complex; RNA aptamer; SELEX; Translation initiation

Indexed keywords

APTAMER; RNA;

ARTICLE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE POOL; GENE SEQUENCE; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RABBIT; RETICULOCYTE LYSATE; RNA STRUCTURE; RNA TRANSLATION; TRANSLATION INITIATION;

ANIMALS; APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BINDING SITES; EUKARYOTIC INITIATION FACTOR-3; EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4G; EUKARYOTIC INITIATION FACTORS; HUMANS; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; RABBITS; RECOMBINANT FUSION PROTEINS; RETICULOCYTES; RNA CAPS; RNA, MESSENGER;

EUKARYOTA; HEPATITIS C VIRUS; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33749256237     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2169406     Document Type: Article

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