Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

African Journal of Pharmacy and Pharmacology

Volumn 5, Issue 3, 2011, Pages 442-446

  Muangman, P ^a   Aramwit, P ^b   Palapinyo, S ^b   Opasanon, S ^a   Chuangsuwanich, A ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Burn; Herbal extracts; Hypertrophic scar

Indexed keywords

ALLANTOIN; ALOE BARBADENSIS EXTRACT; ASIATICOSIDE; CYBELE SCAGEL; MULBERRY EXTRACT; NANOHYDROXYPROLISILANE; ONION EXTRACT; PLANT EXTRACT; SILICONE DERIVATIVE; TAMARIND EXTRACT; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; AGED; ALOE VERA; ARTICLE; BURN; CHILD; CONTROLLED STUDY; DRUG EFFICACY; DRUG HYPERSENSITIVITY; EPITHELIZATION; FEMALE; GEL; HUMAN; HYPERTROPHIC SCAR; MAJOR CLINICAL STUDY; MALE; MULBERRY; ONION; PLIABILITY; PRESCHOOL CHILD; RETROSPECTIVE STUDY; SCHOOL CHILD; SKIN BLOOD FLOW; SKIN PAIN; SKIN PIGMENTATION; SKIN PRURITUS; TAMARIND; WOUND HEALING;

EID: 79957947348     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: 10.5897/AJPP10.282     Document Type: Article

References (41)

1. Alster TS, West TB (1997). Treatment of scars: a review. Ann. Plast. Surg, 39: 418-432.
2. Baek YS, Ryu YB, Curtis-Long MJ, Ha TJ, Rengasamy R, Yang MS, Park KH (2009). Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg. Med. Chem, 17: 35-41.
3. Baryza MJ, Baryza GA (1995). The Vancouver Scar Scale: an administration tool and its interrater reliability. J. Burn. Care Rehabil, 16: 535-538.
4. Beldon P (2000). Abnormal scar formation in wound healing. Nurs. Times, 96: 44-45.
5. Berman B, Viera MH, Amini S, Huo R, Jones IS (2008). Prevention and management of hypertrophic scars and keloids after burns in children. J. Craniofac. Surg., 19: 989-1006.
6. Bloemen MC, van der Veer WM, Ulrich MM, van Zuijlen PP, Niessen FB, Middelkoop E (2009). Prevention and curative management of hypertrophic scar formation. Burns, 35: 463-475.
7. Bock O, Schmid-Ott G, Malewski P, Mrowietz U (2006). Quality of life of patients with keloid and hypertrophic scarring. Arch. Dermatol. Res., 297: 433-438.
8. Bombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, Faucher L, Costa BA, Heimbach DM, Rivara FP, Honari S (2003). What is the prevalence of hypertrophic scarring following burns? Burns, 29: 299-302.
9. Bosse JP, Papillon J, Frenette G, Dansereau J, Cadotte M, Le Lorier J (1979). Clinical study of a new antikeloid agent. Ann. Plast. Surg, 3: 13-21.
10. Brown JJ, Bayat A (2009). Genetic susceptibility to raised dermal scarring. Br. J. Dermatol., 161:8-18.
11. Chithra P, Sajithlal GB, Chandrakasan G (1998). Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol. Cell. Biochem., 181: 71-76.
12. Davis RH, Maro NP (1989). Aloe vera and gibberellin. Anti-inflammatory activity in diabetes. J. Am. Podiatr. Med. Assoc., 79: 24-26.
13. Dunkin CS, Pleat JM, Gillespie PH, Tyler MP, Roberts AH, McGrouther DA (2007). Scarring occurs at a critical depth of skin injury: precise measurement in a graduated dermal scratch in human volunteers. Plast. Reconstr. Surg., 119: 1722-1732; discussion 1733-1724.
14. Gangemi EN, Gregori D, Berchialla P, Zingarelli E, Cairo M, Bollero D, Ganem J, Capocelli R, Cuccuru F, Cassano P, Risso D and Stella M (2008). Epidemiology and risk factors for pathologic scarring after burn wounds. Arch. Facial. Plast. Surg., 10: 93-102.
15. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T and Jeschke MG (2011). Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol. Med., 17: 113-125.
16. Gold MH, Foster TD, Adair MA, Burlison K, Lewis T (2001). Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting. Dermatol. Surg., 27: 641-644.
17. Havinga R, Hartl A, Putscher J, Prehsler S, Buchmann C, Vogl C (2010). Tamarindus indica L. (Fabaceae): patterns of use in traditional African medicine. J. Ethnopharmacol., 127: 573-588.
18. Heggers JP, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, Robson MC, WD (1996). Beneficial effect of Aloe on wound healing in an excisional wound model. J. Altern. Complement Med., 2: 271-277.
19. Henry G and Garner WL (2003). Inflammatory mediators in wound healing. Surg Clin North Am, 83:483-507.
20. Hosnuter M, Payasli C, Isikdemir A, Tekerekoglu B (2007). The effects of onion extract on hypertrophic and keloid scars. J. Wound Care, 16: 251-254.
21. Ju-Lin X, Shao-Hai Q, Tian-Zeng L, Bin H, Jing-Ming T, Ying-Bin X, Xu-Sheng L, Bin S, Hui-Zhen L, Yong H (2009). Effect of asiaticoside on hypertrophic scar in the rabbit ear model. J. Cutan. Pathol., 36: 234-239.
22. Juckett G, Hartman-Adams H (2009). Management of keloids and hypertrophic scars. Am Fam Physician, 80:253-260.
23. Lawrence JC (1967). The effect of asiaticoside on guinea pig skin. J. Invest. Dermatol., 49: 95-96.
24. Muangman P, Chuangsuwanich A, Suwanchot S, Taengthet O, Benjathanung R, Chuntrasakul C (2011). Use of herbal extracts and silicone gel to prevent hypertrophic scar after burn injury: a case report. J. Assoc. Gen. Surgeons Thailand, 12: 1-8.
25. Muangman P, Engrav LH, Heimbach DM, Harunari N, Honari S, Gibran NS, Klein MB (2006). Complex wound management utilizing an artificial dermal matrix. Ann. Plast. Surg., 57: 199-202.
26. Rennekampff HO, Rabbels J, Reinhard V, Becker ST, Schaller HE (2006). Comparing the Vancouver Scar Scale with the cutometer in the assessment of donor site wounds treated with various dressings in a randomized trial. J. Burn. Care Res., 27: 345-351.
27. Rockwell WB, Cohen IK, Ehrlich HP (1989). Keloids and hypertrophic scars: a comprehensive review. Plast. Reconstr. Surg., 84: 827-837.
28. Sasaki S, Shinkai H, Akashi Y, Kishihara Y (1972). Studies on the mechanism of action of asiaticoside (Madecassol) on experimental granulation tissue and cultured fibroblasts and its clinical application in systemic scleroderma. Acta. Derm. Venereol., 52: 141-150.
29. Scott JR, Muangman P, Gibran NS (2007). Making sense of hypertrophic scar: a role for nerves. Wound Repair Regen, 15 Suppl. 1: S27-31.
30. Sherris DA, Larrabee WF, Murakami CS (1995). Management of scar contractures, hypertrophic scars, and keloids. Otolaryngol. Clin. North Am., 28: 1057-1068.
31. Shih B, Bayat A (2010). Genetics of keloid scarring. Arch. Dermatol. Res., 302: 319-339.
32. Singer AJ, McClain SA (2002). Persistent wound infection delays epidermal maturation and increases scarring in thermal burns. Wound Repair Regen., 10: 372-377.
33. Spencer JM (2010). Case series: evaluation of a liquid silicone gel on scar appearance following excisional surgery--a pilot study. J. Drugs Dermatol., 9: 856-858.
34. Stella M, Castagnoli C, Gangemi EN (2008). Postburn scars: an update. Int. J. Low Extrem. Wounds, 7: 176-181.
35. Tandara AA, Mustoe TA (2008). The role of the epidermis in the control of scarring: evidence for mechanism of action for silicone gel. J. Plast. Reconstr. Aesthet. Surg., 61: 1219-1225.
36. van der Wal MB, van Zuijlen PP, van de Ven P, Middelkoop E (2010). Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial. Plast. Reconstr. Surg., 126: 524-531.
37. Van Loey NE, Bremer M, Faber AW, Middelkoop E, Nieuwenhuis MK (2008). Itching following burns: epidemiology and predictors. Br. J. Dermatol., 158: 95-100.
38. Vazquez B, Avila G, Segura D, Escalante B (1996). Antiinflammatory activity of extracts from Aloe vera gel. J. Ethnopharmacol., 55: 69-75.
39. Widgerow AD, Chait LA, Stals R, Stals PJ (2000). New innovations in scar management. Aesthetic Plast. Surg., 24: 227-234.
40. Willital GH, Heine H (1994). Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents. Int. J. Clin. Pharmacol. Res., 14: 193-202.
41. Zurada JM, Kriegel D, Davis IC (2006). Topical treatments for hypertrophic scars. J. Am. Acad. Dermatol., 55: 1024-1031.