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Volumn 161, Issue 1, 2009, Pages 8-18

Genetic susceptibility to raised dermal scarring

Author keywords

Familial tendency; Genetic predisposition; Heritability; Hypertrophic scarring; Keloid disease

Indexed keywords

HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

EID: 67649933647     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09258.x     Document Type: Review
Times cited : (146)

References (57)
  • 1
    • 23344454724 scopus 로고    scopus 로고
    • Clinical management of skin scarring
    • Bayat A, McGrouther DA. Clinical management of skin scarring. Skinmed 2005 4 : 165 73.
    • (2005) Skinmed , vol.4 , pp. 165-73
    • Bayat, A.1    McGrouther, D.A.2
  • 2
    • 21644480368 scopus 로고    scopus 로고
    • Wound-healing studies in transgenic and knockout mice
    • Grose R, Werner S. Wound-healing studies in transgenic and knockout mice. Mol Biotechnol 2004 28 : 147 66.
    • (2004) Mol Biotechnol , vol.28 , pp. 147-66
    • Grose, R.1    Werner, S.2
  • 3
    • 43749088730 scopus 로고    scopus 로고
    • Wound repair and regeneration
    • Gurtner GC, Werner S, Barrandon Y et al. Wound repair and regeneration. Nature 2008 453 : 314 21.
    • (2008) Nature , vol.453 , pp. 314-21
    • Gurtner, G.C.1    Werner, S.2    Barrandon, Y.3
  • 4
    • 0345096457 scopus 로고    scopus 로고
    • 'Aggressive keloid': A severe variant of familial keloid scarring
    • Bayat A, Arscott G, Ollier WE et al. 'Aggressive keloid': a severe variant of familial keloid scarring. J R Soc Med 2003 96 : 554 5.
    • (2003) J R Soc Med , vol.96 , pp. 554-5
    • Bayat, A.1    Arscott, G.2    Ollier, W.E.3
  • 6
    • 33750384109 scopus 로고    scopus 로고
    • Spectrum of abnormal skin scars and their clinical management
    • Bayat A, McGrouther DA. Spectrum of abnormal skin scars and their clinical management. Br J Hosp Med (Lond) 2006 67 : 527 32.
    • (2006) Br J Hosp Med (Lond) , vol.67 , pp. 527-32
    • Bayat, A.1    McGrouther, D.A.2
  • 7
  • 8
    • 34548131208 scopus 로고    scopus 로고
    • Cellular and molecular pathology of HTS: Basis for treatment
    • Armour A, Scott PG, Tredget EE. Cellular and molecular pathology of HTS: basis for treatment. Wound Repair Regen 2007 15 (Suppl. 1 S6 17.
    • (2007) Wound Repair Regen , vol.15 , Issue.SIPPL. 1 , pp. 6-17
    • Armour, A.1    Scott, P.G.2    Tredget, E.E.3
  • 9
    • 55449114249 scopus 로고    scopus 로고
    • Prevention and management of hypertrophic scars and keloids after burns in children
    • Berman B, Viera MH, Amini S et al. Prevention and management of hypertrophic scars and keloids after burns in children. J Craniofac Surg 2008 19 : 989 1006.
    • (2008) J Craniofac Surg , vol.19 , pp. 989-1006
    • Berman, B.1    Viera, M.H.2    Amini, S.3
  • 10
    • 39849098266 scopus 로고    scopus 로고
    • Keloids and hypertrophic scars: Are they two different sides of the same coin?
    • Kose O, Waseem A. Keloids and hypertrophic scars: are they two different sides of the same coin? Dermatol Surg 2008 34 : 336 46.
    • (2008) Dermatol Surg , vol.34 , pp. 336-46
    • Kose, O.1    Waseem, A.2
  • 11
    • 0036400609 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the 3′-UTR of the TGFbetaRI and TGFbetaRIII genes
    • Bayat A, Watson JS, Stanley JK et al. Novel single nucleotide polymorphisms in the 3′-UTR of the TGFbetaRI and TGFbetaRIII genes. Eur J Immunogenet 2002 29 : 445 6.
    • (2002) Eur J Immunogenet , vol.29 , pp. 445-6
    • Bayat, A.1    Watson, J.S.2    Stanley, J.K.3
  • 12
    • 0016707690 scopus 로고
    • Genetic studies on keloid
    • Omo-Dare P. Genetic studies on keloid. J Natl Med Assoc 1975 67 : 428 32.
    • (1975) J Natl Med Assoc , vol.67 , pp. 428-32
    • Omo-Dare, P.1
  • 14
    • 0025308160 scopus 로고
    • Keloids: A review of the literature
    • Datubo-Brown DD. Keloids: a review of the literature. Br J Plast Surg 1990 43 : 70 7.
    • (1990) Br J Plast Surg , vol.43 , pp. 70-7
    • Datubo-Brown, D.D.1
  • 15
    • 0018351515 scopus 로고
    • Rubinstein-Taybi syndrome and spontaneous keloids
    • Kurwa AR. Rubinstein-Taybi syndrome and spontaneous keloids. Clin Exp Dermatol 1979 4 : 251 4.
    • (1979) Clin Exp Dermatol , vol.4 , pp. 251-4
    • Kurwa, A.R.1
  • 17
    • 0019460447 scopus 로고
    • Rubinstein-Taybi syndrome. Cutaneous manifestations and colossal keloids
    • Selmanowitz VJ, Stiller MJ. Rubinstein-Taybi syndrome. Cutaneous manifestations and colossal keloids. Arch Dermatol 1981 117 : 504 6.
    • (1981) Arch Dermatol , vol.117 , pp. 504-6
    • Selmanowitz, V.J.1    Stiller, M.J.2
  • 18
    • 0025034921 scopus 로고
    • Rubinstein-Taybi syndrome: A follow-up study
    • Partington MW. Rubinstein-Taybi syndrome: a follow-up study. Am J Med Genet Suppl 1990 6 : 65 8.
    • (1990) Am J Med Genet Suppl , vol.6 , pp. 65-8
    • Partington, M.W.1
  • 19
    • 0029882281 scopus 로고    scopus 로고
    • Rubinstein-Taybi syndrome with multiple flamboyant keloids
    • Hendrix JD Jr., Greer KE. Rubinstein-Taybi syndrome with multiple flamboyant keloids. Cutis 1996 57 : 346 8.
    • (1996) Cutis , vol.57 , pp. 346-8
    • Hendrix, Jr.J.D.1    Greer, K.E.2
  • 20
    • 0014303468 scopus 로고
    • A new probably X-linked inherited syndrome: Congenital muscular torticollis, multiple keloids cryptorchidism and renal dysplasia
    • Goeminne L. A new probably X-linked inherited syndrome: congenital muscular torticollis, multiple keloids cryptorchidism and renal dysplasia. Acta Genet Med Gemellol (Roma) 1968 17 : 439 67.
    • (1968) Acta Genet Med Gemellol (Roma) , vol.17 , pp. 439-67
    • Goeminne, L.1
  • 21
    • 33846081436 scopus 로고    scopus 로고
    • Ehlers-Danlos syndrome type IV: Keloidal plaques of the lower extremities, amniotic band limb deformity, and a new mutation
    • Burk CJ, Aber C, Connelly EA. Ehlers-Danlos syndrome type IV: keloidal plaques of the lower extremities, amniotic band limb deformity, and a new mutation. J Am Acad Dermatol 2007 56 : S53 4.
    • (2007) J Am Acad Dermatol , vol.56 , pp. 53-4
    • Burk, C.J.1    Aber, C.2    Connelly, E.A.3
  • 22
    • 0020448834 scopus 로고
    • Gene mapping and serendipity. the locus for torticollis, keloids, cryptorchidism and renal dysplasia (31430, McKusick) is at Xq28, distal to the G6PD locus
    • Zuffardi O, Fraccaro M. Gene mapping and serendipity. The locus for torticollis, keloids, cryptorchidism and renal dysplasia (31430, McKusick) is at Xq28, distal to the G6PD locus. Hum Genet 1982 62 : 280 1.
    • (1982) Hum Genet , vol.62 , pp. 280-1
    • Zuffardi, O.1    Fraccaro, M.2
  • 23
    • 2442606249 scopus 로고    scopus 로고
    • Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11
    • Marneros AG, Norris JE, Watanabe S et al. Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol 2004 122 : 1126 32.
    • (2004) J Invest Dermatol , vol.122 , pp. 1126-32
    • Marneros, A.G.1    Norris, J.E.2    Watanabe, S.3
  • 24
    • 42449085064 scopus 로고    scopus 로고
    • [Linkage analysis of keloid susceptibility loci on chromosome 7p11 in a Chinese pedigree]
    • [in Chinese].
    • Chen Y, Gao JH, Liu XJ et al. [Linkage analysis of keloid susceptibility loci on chromosome 7p11 in a Chinese pedigree]. Nan Fang Yi Ke Da Xue Xue Bao 2006 26 : 623 5 [in Chinese].
    • (2006) Nan Fang Yi Ke da Xue Xue Bao , vol.26 , pp. 623-5
    • Chen, Y.1    Gao, J.H.2    Liu, X.J.3
  • 25
    • 67349153639 scopus 로고    scopus 로고
    • [Preliminary linkage analysis and mapping of keloid susceptibility locus in a Chinese pedigree]
    • [in Chinese].
    • Yan X, Gao JH, Chen Y et al. [Preliminary linkage analysis and mapping of keloid susceptibility locus in a Chinese pedigree]. Zhonghua Zheng Xing Wai Ke Za Zhi 2007 23 : 32 5 [in Chinese].
    • (2007) Zhonghua Zheng Xing Wai Ke Za Zhi , vol.23 , pp. 32-5
    • Yan, X.1    Gao, J.H.2    Chen, Y.3
  • 26
    • 1942468902 scopus 로고    scopus 로고
    • Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways
    • Satish L, Babu M, Tran KT et al. Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. Wound Repair Regen 2004 12 : 183 92.
    • (2004) Wound Repair Regen , vol.12 , pp. 183-92
    • Satish, L.1    Babu, M.2    Tran, K.T.3
  • 27
    • 33645073413 scopus 로고    scopus 로고
    • Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring
    • Yu H, Bock O, Bayat A et al. Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring. J Plast Reconstr Aesthet Surg 2006 59 : 221 9.
    • (2006) J Plast Reconstr Aesthet Surg , vol.59 , pp. 221-9
    • Yu, H.1    Bock, O.2    Bayat, A.3
  • 28
    • 33747590974 scopus 로고    scopus 로고
    • Gene expression patterns in isolated keloid fibroblasts
    • Satish L, Lyons-Weiler J, Hebda PA et al. Gene expression patterns in isolated keloid fibroblasts. Wound Repair Regen 2006 14 : 463 70.
    • (2006) Wound Repair Regen , vol.14 , pp. 463-70
    • Satish, L.1    Lyons-Weiler, J.2    Hebda, P.A.3
  • 29
    • 3242667963 scopus 로고    scopus 로고
    • Development of gene microarray in screening differently expressed genes in keloid and normal-control skin
    • Chen W, Fu XB, Ge SL et al. Development of gene microarray in screening differently expressed genes in keloid and normal-control skin. Chin Med J (Engl) 2004 117 : 877 81.
    • (2004) Chin Med J (Engl) , vol.117 , pp. 877-81
    • Chen, W.1    Fu, X.B.2    Ge, S.L.3
  • 30
    • 1842583836 scopus 로고    scopus 로고
    • Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation
    • Dasu MR, Hawkins HK, Barrow RE et al. Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. J Pathol 2004 202 : 476 85.
    • (2004) J Pathol , vol.202 , pp. 476-85
    • Dasu, M.R.1    Hawkins, H.K.2    Barrow, R.E.3
  • 31
    • 11144284874 scopus 로고    scopus 로고
    • Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization
    • Na GY, Seo SK, Lee SJ et al. Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization. Br J Dermatol 2004 151 : 1143 9.
    • (2004) Br J Dermatol , vol.151 , pp. 1143-9
    • Na, G.Y.1    Seo, S.K.2    Lee, S.J.3
  • 32
    • 27644527952 scopus 로고    scopus 로고
    • Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage
    • Naitoh M, Kubota H, Ikeda M et al. Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage. Genes Cells 2005 10 : 1081 91.
    • (2005) Genes Cells , vol.10 , pp. 1081-91
    • Naitoh, M.1    Kubota, H.2    Ikeda, M.3
  • 33
    • 33746522802 scopus 로고    scopus 로고
    • A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays
    • Leppert PC, Catherino WH, Segars JH. A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am J Obstet Gynecol 2006 195 : 415 20.
    • (2006) Am J Obstet Gynecol , vol.195 , pp. 415-20
    • Leppert, P.C.1    Catherino, W.H.2    Segars, J.H.3
  • 34
    • 41949132878 scopus 로고    scopus 로고
    • [Differential gene expression profile of keloids: A study with cDNA microarray]
    • [in Chinese].
    • Hu ZF, Gao JH, Li W et al. [Differential gene expression profile of keloids: a study with cDNA microarray]. Nan Fang Yi Ke Da Xue Xue Bao 2006 26 : 308 12 [in Chinese].
    • (2006) Nan Fang Yi Ke da Xue Xue Bao , vol.26 , pp. 308-12
    • Hu, Z.F.1    Gao, J.H.2    Li, W.3
  • 36
    • 35649022658 scopus 로고    scopus 로고
    • Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites
    • Xia W, Kong W, Wang Z et al. Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites. Ann Surg 2007 246 : 886 95.
    • (2007) Ann Surg , vol.246 , pp. 886-95
    • Xia, W.1    Kong, W.2    Wang, Z.3
  • 37
    • 35448993355 scopus 로고    scopus 로고
    • Genomic and proteomic profiling II: Comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically induced scars
    • Luo X, Pan Q, Liu L et al. Genomic and proteomic profiling II: comparative assessment of gene expression profiles in leiomyomas, keloids, and surgically induced scars. Reprod Biol Endocrinol 2007 5 : 35.
    • (2007) Reprod Biol Endocrinol , vol.5 , pp. 35
    • Luo, X.1    Pan, Q.2    Liu, L.3
  • 38
    • 43249098374 scopus 로고    scopus 로고
    • A novel truncated TGF-beta receptor II downregulates collagen synthesis and TGF-beta i secretion of keloid fibroblasts
    • Chu Y, Guo F, Li Y et al. A novel truncated TGF-beta receptor II downregulates collagen synthesis and TGF-beta I secretion of keloid fibroblasts. Connect Tissue Res 2008 49 : 92 8.
    • (2008) Connect Tissue Res , vol.49 , pp. 92-8
    • Chu, Y.1    Guo, F.2    Li, Y.3
  • 39
    • 52049102028 scopus 로고    scopus 로고
    • TGF-beta1 antisense therapy modulates expression of matrix metalloproteinases in keloid-derived fibroblasts
    • Sadick H, Herberger A, Riedel K et al. TGF-beta1 antisense therapy modulates expression of matrix metalloproteinases in keloid-derived fibroblasts. Int J Mol Med 2008 22 : 55 60.
    • (2008) Int J Mol Med , vol.22 , pp. 55-60
    • Sadick, H.1    Herberger, A.2    Riedel, K.3
  • 40
    • 42149158926 scopus 로고    scopus 로고
    • Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways
    • Smith JC, Boone BE, Opalenik SR et al. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol 2008 128 : 1298 310.
    • (2008) J Invest Dermatol , vol.128 , pp. 1298-310
    • Smith, J.C.1    Boone, B.E.2    Opalenik, S.R.3
  • 41
    • 40349093374 scopus 로고    scopus 로고
    • Identification of unique gene expression patterns within different lesional sites of keloids
    • Seifert O, Bayat A, Geffers R et al. Identification of unique gene expression patterns within different lesional sites of keloids. Wound Repair Regen 2008 16 : 254 65.
    • (2008) Wound Repair Regen , vol.16 , pp. 254-65
    • Seifert, O.1    Bayat, A.2    Geffers, R.3
  • 42
    • 34547911400 scopus 로고    scopus 로고
    • Biological differences between fibroblasts derived from peripheral and central areas of keloid tissues
    • Lu F, Gao J, Ogawa R et al. Biological differences between fibroblasts derived from peripheral and central areas of keloid tissues. Plast Reconstr Surg 2007 120 : 625 30.
    • (2007) Plast Reconstr Surg , vol.120 , pp. 625-30
    • Lu, F.1    Gao, J.2    Ogawa, R.3
  • 43
    • 59449095904 scopus 로고    scopus 로고
    • Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients
    • Nassiri M, Woolery-Lloyd H, Ramos S et al. Gene expression profiling reveals alteration of caspase 6 and 14 transcripts in normal skin of keloid-prone patients. Arch Dermatol Res 2008 301 : 183 8.
    • (2008) Arch Dermatol Res , vol.301 , pp. 183-8
    • Nassiri, M.1    Woolery-Lloyd, H.2    Ramos, S.3
  • 44
    • 0037314377 scopus 로고    scopus 로고
    • Genetic susceptibility to keloid disease and hypertrophic scarring: Transforming growth factor beta1 common polymorphisms and plasma levels
    • Bayat A, Bock O, Mrowietz U et al. Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels. Plast Reconstr Surg 2003 111 : 535 43.
    • (2003) Plast Reconstr Surg , vol.111 , pp. 535-43
    • Bayat, A.1    Bock, O.2    Mrowietz, U.3
  • 45
    • 34447625195 scopus 로고    scopus 로고
    • Transforming growth factor beta (TGFbeta) and keloid disease
    • Jagadeesan J, Bayat A. Transforming growth factor beta (TGFbeta) and keloid disease. Int J Surg 2007 5 : 278 85.
    • (2007) Int J Surg , vol.5 , pp. 278-85
    • Jagadeesan, J.1    Bayat, A.2
  • 46
    • 0036316327 scopus 로고    scopus 로고
    • Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms
    • Bayat A, Bock O, Mrowietz U et al. Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms. Br J Plast Surg 2002 55 : 283 6.
    • (2002) Br J Plast Surg , vol.55 , pp. 283-6
    • Bayat, A.1    Bock, O.2    Mrowietz, U.3
  • 47
    • 26044443790 scopus 로고    scopus 로고
    • Genetic susceptibility to keloid disease: Mutation screening of the TGFbeta3 gene
    • Bayat A, Walter JM, Bock O et al. Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene. Br J Plast Surg 2005 58 : 914 21.
    • (2005) Br J Plast Surg , vol.58 , pp. 914-21
    • Bayat, A.1    Walter, J.M.2    Bock, O.3
  • 48
    • 1342284183 scopus 로고    scopus 로고
    • Genetic susceptibility to keloid disease: Transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease
    • Bayat A, Bock O, Mrowietz U et al. Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease. Exp Dermatol 2004 13 : 120 4.
    • (2004) Exp Dermatol , vol.13 , pp. 120-4
    • Bayat, A.1    Bock, O.2    Mrowietz, U.3
  • 49
    • 44949206532 scopus 로고    scopus 로고
    • Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans
    • Brown JJ, Ollier W, Arscott G et al. Genetic susceptibility to keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans. Exp Dermatol 2008 17 : 610 13.
    • (2008) Exp Dermatol , vol.17 , pp. 610-13
    • Brown, J.J.1    Ollier, W.2    Arscott, G.3
  • 50
    • 52649141501 scopus 로고    scopus 로고
    • Positive association of HLA-DRB1*15 with keloid disease in Caucasians
    • Brown JJ, Ollier WE, Thomson W et al. Positive association of HLA-DRB1*15 with keloid disease in Caucasians. Int J Immunogenet 2008 35 : 303 7.
    • (2008) Int J Immunogenet , vol.35 , pp. 303-7
    • Brown, J.J.1    Ollier, W.E.2    Thomson, W.3
  • 51
    • 51249084579 scopus 로고    scopus 로고
    • Association of HLA-DQA1 and DQB1 alleles with keloids in Chinese Hans
    • Lu WS, Wang JF, Yang S et al. Association of HLA-DQA1 and DQB1 alleles with keloids in Chinese Hans. J Dermatol Sci 2008 52 : 108 17.
    • (2008) J Dermatol Sci , vol.52 , pp. 108-17
    • Lu, W.S.1    Wang, J.F.2    Yang, S.3
  • 52
    • 0344873297 scopus 로고    scopus 로고
    • On and off: Proteasome and TGF-beta signaling
    • Zhang F, Laiho M. On and off: proteasome and TGF-beta signaling. Exp Cell Res 2003 291 : 275 81.
    • (2003) Exp Cell Res , vol.291 , pp. 275-81
    • Zhang, F.1    Laiho, M.2
  • 53
    • 35348843493 scopus 로고    scopus 로고
    • Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts
    • Wang Z, Gao Z, Shi Y et al. Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts. J Plast Reconstr Aesthet Surg 2007 60 : 1193 9.
    • (2007) J Plast Reconstr Aesthet Surg , vol.60 , pp. 1193-9
    • Wang, Z.1    Gao, Z.2    Shi, Y.3
  • 55
    • 0035036395 scopus 로고    scopus 로고
    • Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles
    • Santucci M, Borgognoni L, Reali UM et al. Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles. Virchows Arch 2001 438 : 457 63.
    • (2001) Virchows Arch , vol.438 , pp. 457-63
    • Santucci, M.1    Borgognoni, L.2    Reali, U.M.3


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