Persistent wound infection delays epidermal maturation and increases scarring in thermal burns

Wound Repair and Regeneration

Volumn 10, Issue 6, 2002, Pages 372-377

  Singer, Adam J ^a   McClain, Steve A ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; BURN SCAR; EPIDERMIS; FEMALE; NONHUMAN; PRIORITY JOURNAL; SCAR FORMATION; SWINE; THERMAL INJURY; WOUND HEALING; WOUND INFECTION;

ANIMALS; BURNS; CICATRIX; DISEASE MODELS, ANIMAL; EPIDERMIS; FEMALE; REPRODUCIBILITY OF RESULTS; SWINE; TIME FACTORS; TRAUMA SEVERITY INDICES; WOUND HEALING; WOUND INFECTION;

EID: 0036869685     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2002.10606.x     Document Type: Article

References (25)

1. Carrel A. Cicatrization of wounds - XII, Factors initiating regeneration. J Exp Med 1921;34:425-35.
2. Carrel A, Hartman A. Cicatrization of wounds: The relation between the size of the wound and the rate if its cicatrization. J Exp Med 1916;24:429-50.
3. Robson MC. Wound infection. A failure of wound healing caused by an imbalance of bacteria. Surg Clin N Am 1997;77:637-50.
4. Smith M, Enquist IF. A quantitative study of impaired healing resulting from infection. Surg Gyn Obstet 1967;125:965-73.
5. de Haan BB, Ellis H, Wilks M. The role of infection on wound healing. Surg Gyn Obstet 1974;138:693-700.
6. Segree WA, James O, Morris DE, Haase DA. Bacteriologic studies of infected wounds. West Indian Med J 1970;19:65-70.
7. Keill RH, Nichols WK, DeWeese MS. Abdominal wound dehiscence. Arch Surg 1973;106:573-7.
8. Robson MC, Lea CE, Dalton JB, Heggers JP. Quantitative bacteriology and delayed wound closure. Surg Forum 1968;19:501-2.
9. Robson MC, Heggers JP. Delayed wound closures based on bacterial counts. J Surg Oncol 1970;2:379-83.
10. Gillman T, Penn J, Bronks D, Roux M. A re-examination of certain aspects of the histogenesis of the healing of cutaneous wounds. A preliminary report. Brit J Surg 1955;43:141-53.
11. Singer AJ, Mohammad M, Tortora G, Thode HC Jr, McClain SA. Octyl-cyanoacrylate for the treatment of contaminated partial thickness burns in swine. A randomized controlled study. Acad Emerg Med 2000;7:222-7.
12. Hartwell SW. The Mechanism of Healing in Human Wounds. Springfield, IL: Thomas, 1955.
13. National Research Council. Guide for The Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996.
14. Singer AJ, Berrutti L, Thode HC Jr, McClain SA. Standardized burn model using a multi-parametric histological analysis of burn depth. Acad Emerg Med 2000;7:1-6.
15. Thomson PD, Smith DJ. What is infection? Am J Surg 1994;167: 7S-11S.
16. Ackerman AB. Histologic diagnosis of inflammatory skin diseases. An Algorithmic Method Based on Pattern Analysis. 2nd Ed. Baltimore: Williams & Wilkins, 1997:76-98.
17. Singer AJ, McClain SA, Thode HC Jr. Development of a histomorphologic scale to quantify cutaneous scars after burns. Acad Emerg Med 2000;7:1083-8.
18. Singer AJ, Clark RAF. Advances in cutaneous wound healing. N Engl J Med 1999;341:738-46.
19. Robson MC, Stenberg BD, Heggers JP. Wound healing alterations caused by bacteria. Clin Plast Surg 1990;17:485-92.
20. Singer AJ, McClain SA, Soroff HS. The effects of Santyl and infection on burn healing in swine. Acad Emerg Med 2001;8:520. [Abstract].
21. Singer AJ, Quinn JV, Thode HC, Hollander JE. Determinants of poor outcome after laceration and surgical incision repair. Plast Reconstr Surg 2002;110:429-35.
22. Okamoto T, Akaike T, Suga M, Tanase S, Horie H, Miyajima S, Ando M, Ichinose Y, Maeda H. Activation of human matrix metalloproteinases by various bacterial proteinases. J Biol Chem 1997;272:6059-66.
23. Potempa J, Banbula A, Travis J. Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontology 2000;24:153-92.
24. Clark RAF, Lanigan JM, DellaPelle P, Manseau E, Dvorak HV, Colvin RB. Fibronectin and fibrin provide a provisional matrix for epidermal migration during wound reepithelialization. J Invest Dermatol 1982;79:264-9.
25. Quinn JV, Maw JL, Ramotar K, Wenckenbach G, Wells GA. Octylcyanoacrylate tissue adhesive wound repair versus suture wound repair in a contaminated wound model. Surgery 1997;122:69-72.