Scarring occurs at a critical depth of skin injury: Precise measurement in a graduated dermal scratch in human volunteers

Plastic and Reconstructive Surgery

Volumn 119, Issue 6, 2007, Pages 1722-1732

  Dunkin, Christopher S J ^a,b   Pleat, Jonathon M ^a   Gillespie, Patrick H ^a   Tyler, Michael P H ^a   Roberts, Anthony H N ^a   McGrouther, D Angus ^a  

^a STOKE MANDEVILLE HOSPITAL   (United Kingdom)

^b NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CALCULATION; FEMALE; FOLLOW UP; HUMAN; INJURY SEVERITY; MALE; MEASUREMENT; NORMAL HUMAN; PHOTOGRAPHY; PRIORITY JOURNAL; SCAR FORMATION; SKIN; SKIN INJURY; ULTRASOUND; WOUND HEALING;

ADOLESCENT; ADULT; AGED; BURNS; CICATRIX; DERMIS; FEMALE; HUMAN EXPERIMENTATION; HUMANS; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PHOTOGRAPHY; PILOT PROJECTS; REGENERATION; SENSITIVITY AND SPECIFICITY; SKIN; SKIN PHYSIOLOGY; ULTRASONOGRAPHY, DOPPLER; WOUND HEALING; WOUNDS AND INJURIES;

EID: 34247325224     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000258829.07399.f0     Document Type: Article

References (25)

1. Gillespie, P. E. Skin thickness measured using a new high resolution ultrasound scanner. In Proceedings of the British Association of Plastic Surgery Winter Meeting, London, England, December 3-5, 1999.
2. Ross, E. V., Naseef, G. S., McKinlay, J. R., et al. Comparison of CO2 laser, erbium:YAG laser, dermabrasion and dermatome: A study of thermal damage, wound contraction and wound healing in live pig model. Implications for resurfacing. J. Am. Acad. Dermatol. 42: 92, 2000.
3. Kann, P., Zawalski, R., Piepkorn, P., Schehler, B., and Beyer, J. Validation of a mechanical method for measuring skin thickness: Relation to age, body mass index, skin thickness determined by ultrasound and bone mineral density. Exp. Clin. Endocrinol. Diabetes 103: 113, 1995.
4. Bland, J. M., and Altman, D. G. Comparing methods of measurement: Why plotting difference against standard method is misleading. Lancet 346: 1085, 1995.
5. Schilling, J. A. Wound healing. Surg. Clin. North Am. 56: 859, 1976.
6. Clark, R. A. F. Overview of wound repair. In R. A. F. Clark (Ed.), The Molecular and Cellular Biology of Wound Repair. New York: Plenum Press, 1996. Pp. 3-50.
7. Cowin, A. J., Brosnan, M. P., Holmes, T. M., and Ferguson, M. W. Endogenous inflammatory response to dermal wound healing in the fetal and adult mouse. Dev. Dyn. 212: 385, 1998.
8. Martin, P., D'Souza, D. Martin, J., et al. Wound healing in the PU.1 null mouse: Tissue repair is not dependent on inflammatory cells. Curr. Biol. 13: 1122, 2003.
9. Padgett, E. C. Calibrated intermediate skin grafts. Surg. Gynecol. Obstet. 69: 779, 1939.
10. Converse, J. M., and Robb-Smith, A. H. T. The healing of surface cutaneous wounds: Its analogy with the healing of superficial burns. Ann. Surg. 120: 873, 1944.
11. Janzekovic, Z. A new concept in the early excision and immediate grafting of burns. J. Trauma 10: 1103, 1970.
12. Pape, S., Skouras, C., and Byrne, P. An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth. Burns 27: 233, 2001.
13. Seukeran, D. C., Collins, P., and Sheehan-Dare, R. A. Adverse reactions following pulsed tunable dye laser treatment of port wine stains in 701 patients. Br. J. Dermatol. 136: 725, 1997.
14. Milner, S. M., Memar, O. M., Gherardini, G., Bennett, J. C. D., and Phillips, L.G. The histological interpretation of high frequency cutaneous ultrasound images. Dermatol. Surg. 23: 43, 1997.
15. Rippon, M., Sprigett, K., Walmsley, R., Patrick, K., and Millson, S. Ultrasound assessment of skin and wound tissue: Comparison with histology. Skin Res. Technol. 4: 147, 1998.
16. Overgaard Olsen, L., Takiwaki, H., and Serup, J. High frequency ultrasound characterisation of normal skin: Skin thickness and echographic density of 22 anatomical sites. Skin Res. Technol. 1: 74, 1995.
17. Dyson, M., Moodley, S., Verjee, L., Verling, W., Weinman, J., and Wilson, P. Wound healing assessment using 20MHz ultrasound and photography. Skin Res. Technol. 9: 1, 2003.
18. Richard, S., Duteil, L., Poli, F., et al. Echographic assessment of corticosteroid induced skin thinning, including echogenicity measurement. Skin Res. Technol. 2: 18, 1996.
19. Kischer, C., Shetlar, M. R., and Chvapil, M. Hypertrophic scars and keloids: A review and new concept concerning their origin. Scan. Electron Microsc. Pt. 4: 1699, 1982.
20. Yeh, A. T., Kao, B., Jung, W. G., Chen, Z., Nelson, J. S., and Tromberg, B. J. Imaging wound healing using optical co-herence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model. J. Biomed. Opt. 9: 248, 2004.
21. Timar-Banu, O., Beauregard, H., Tousignant, J., et al. Development of non-invasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans. Wound Repair Regen. 9: 123, 2001.
22. Azzarone, B., and Maciera-Coelho, A. Heterogeneity of the kinetics of proliferation within human skin fibroblastic skin populations. J. Cell Sci. 57: 177, 1982.
23. Schafer, I. A., Pandy, M., Ferguson, R., and Davis, B. R. Comparative observation of fibroblasts derived from the papillary and reticular dermis of infants and adults: Growth kinetics, packing density at confluence and morphology. Mech. Ageing Dev. 31: 275, 1985.
24. Schonherr, E., Beavan, L. A., Hausser, H., Kresse, H., and Culp, L. Differences in decorin expression by papillary and reticular fibroblasts in vivo and in vitro. Biochem. J. 290: 893, 1993.
25. Ferguson, M. W., Whitby, D. J., Shah, M., Armstrong, J., Siebert, J. W., and Longaker, M. T. Scar formation: The spectral nature of fetal and adult wound repair. Plast. Reconstr. Surg. 97: 854, 1996.