Bioactive Dietary Polyphenols Inhibit Heme Iron Absorption in a Dose-Dependent Manner in Human Intestinal Caco-2 Cells

Journal of Food Science

Volumn 76, Issue 5, 2011, Pages

  Ma, Qianyi ^a   Kim, Eun Young ^a   Lindsay, Elizabeth Ann ^a   Han, Okhee ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

( ) epigallocatechin 3 gallate (EGCG); Ascorbic acid; Grape seed extract; Green tea; Heme iron absorption

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CATECHIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; GRAPE SEED EXTRACT; HEME; PLANT EXTRACT; POLYPHENOL;

ANIMAL; ARTICLE; BLOOD; CELL STRAIN CACO 2; CHEMISTRY; CYTOLOGY; DIET; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; INTESTINE; INTESTINE ABSORPTION; INTESTINE CELL; IRON INTAKE; METABOLISM; MOUSE; TEA; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CATECHIN; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCYTES; GRAPE SEED EXTRACT; HEME; HUMANS; INTESTINAL ABSORPTION; INTESTINES; IRON, DIETARY; MICE; PLANT EXTRACTS; POLYPHENOLS; TEA;

VITACEAE;

EID: 79957889305     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2011.02184.x     Document Type: Article

References (40)

1. Astill C, Birch MR, Dacombe C, Humphrey PG, Martin PT. 2001. Factors affecting the caffeine and polyphenol contents of black and green tea infusions. J Agric Food Chem 49:5340-7.
2. Beard J, Han O. 2009. Systemic iron status. Biochim Biophys Acta 1790:584-8.
3. Bezwoda WR, Bothwell TH, Charlton RW, Torrance JD, MacPhail AP, Derman DP, Mayet F. 1983. The relative dietary importance of haem and non-haem iron. S Afr Med J 64:552-6.
4. Bose M, Lambert JD, Ju J, Reuhl KR, Shapses SA, Yang CS. 2008. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr 138:1677-83.
5. Britton RS, Ramm GA, Olynyk J, Singh R, O'Neill R, Bacon BR. 1994. Pathophysiology of iron toxicity. Adv Exp Med Biol 356:239-53.
6. Burton DD, Kim HJ, Camilleri M, Stephens DA, Mullan BP, O'Connor MK, Talley NJ. 2005. Relationship of gastric emptying and volume changes after a solid meal in humans. Am J Physiol Gastrointest Liver Physiol 289:G261-6.
7. Carpenter CE, Mahoney AW. 1992. Contributions of heme and nonheme iron to human nutrition. Crit Rev Food Sci Nutr 31:333-67.
8. Conrad ME, Benjamin BI, Williams HL, Foy AL. 1967. Human absorption of hemoglobin-iron. Gastroenterology 53:5-10.
9. Cook JD, Reddy MB, Hurrell RF. 1995. The effect of red and white wines on nonheme-iron absorption in humans. Am J Clin Nutr 61:800-4.
10. Disler PB, Lynch SR, Charlton RW, Torrance JD, Bothwell TH, Walker RB, Mayet F. 1975. The effect of tea on iron absorption. Gut 16:193-200.
11. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. 2000. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403:776-81.
12. Frederiksen H, Mortensen A, Schroder M, Frandsen H, Bysted A, Knuthsen P, Rasmussen SE. 2007. Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Mol Nutr Food Res 51:564-71.
13. Hallberg L, Brune M, Rossander L. 1989. Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am J Clin Nutr 49:140-4.
14. Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hulten L. 1991. Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 53:112-9.
15. Han O, Kim EY. 2007. Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells. J Cell Biochem 101:1000-10.
16. Han O, Failla ML, Hill AD, Morris ER, Smith JC, Jr. 1995. Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells. J Nutr 125:1291-9.
17. Hazell T, Ledward DA, Neale RJ. 1982. Hemoglobin and meat iron absorption. Am J Clin Nutr 36:187-9.
18. Hentze MW, Muckenthaler MU, Andrews NC. 2004. Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285-97.
19. Huebers H, Huebers E, Csiba E, Finch CA. 1978. Iron uptake from rat plasma transferrin by rat reticulocytes. J Clin Invest 62:944-51.
20. Hurrell RF, Reddy M, Cook JD. 1999. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br J Nutr 81:289-95.
21. Kim EY, Ham SK, Shigenaga MK, Han O. 2008. Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers. J Nutr 138:1647-51.
22. Lopez MA, Martos FC. 2004. Iron availability: an updated review. Int J Food Sci Nutr 55:597-606.
23. Louvard D, Kedinger M, Hauri HP. 1992. The differentiating intestinal epithelial cell: establishment and maintenance of functions through interactions between cellular structures. Annu Rev Cell Biol 8:157-95.
24. Lu QY, Jin YS, Pantuck A, Zhang ZF, Heber D, Belldegrun A, Brooks M, Figlin R, Rao J. 2005. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model. Clin Cancer Res 11:1675-83.
25. Lynch SR, Dassenko SA, Morck TA, Beard JL, Cook JD. 1985. Soy protein products and heme iron absorption in humans. Am J Clin Nutr 41:13-20.
26. Ma Q, Kim EY, Han O. 2010. Bioactive dietary polyphenols decrease heme iron absorption by decreasing basolateral iron release in human intestinal Caco-2 cells. J Nutr 140:1117-21.
27. Maines M. 1996. Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity. Methods Enzymol 268:473-88.
28. Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB. 2006. Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Mol Nutr Food Res 50:229-34.
29. Raffin SB, Woo CH, Roost KT, Price DC, Schmid R. 1974. Intestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase. J Clin Invest 54:1344-52.
30. Raja KB, Simpson RJ, Peters TJ. 1992. Investigation of a role for reduction in ferric iron uptake by mouse duodenum. Biochim Biophys Acta 1135:141-6.
31. Sanchez-Moreno C, Cao G, Ou B, Prior RL. 2003. Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity comparison with nontraditional wines obtained from highbush blueberry. J Agric Food Chem 51:4889-96.
32. Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT. 2005. Identification of an intestinal heme transporter. Cell 122:789-801.
33. Thankachan P, Walczyk T, Muthayya S, Kurpad AV, Hurrell RF. 2008. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr 87:881-6.
34. Torre M, Rodriguez AR, Saura-Calixto F. 1991. Effects of dietary fiber and phytic acid on mineral availability. Crit Rev Food Sci Nutr 30:1-22.
35. Tsang C, Auger C, Mullen W, Bornet A, Rouanet JM, Crozier A, Teissedre PL. 2005. The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. Br J Nutr 94:170-81.
36. Tuntawiroon M, Sritongkul N, Brune M, Rossander-Hulten L, Pleehachinda R, Suwanik R, Hallberg L. 1991. Dose-dependent inhibitory effect of phenolic compounds in foods on nonheme-iron absorption in men. Am J Clin Nutr 53:554-7.
37. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. 1999. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21:195-9.
38. Weintraub LR, Weinstein MB, Huser HJ, Rafal S. 1968. Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa. J Clin Invest 47:531-9.
39. Wheby MS, Spyker DA. 1981. Hemoglobin iron absorption kinetics in the iron-deficient dog. Am J Clin Nutr 34:1686-93.
40. WHO. 2008. Worldwide prevalence of anaemia 1993-2005. In: de Benoist B, McLean E, Egli I, Cogswell M, editor. WHO global database on anaemia. Geneva, Switzerland WHO.