Behavior of Parasite-Specific Effector CD8+ T Cells in the Brain and Visualization of a Kinesis-Associated System of Reticular Fibers

Immunity

Volumn 30, Issue 2, 2009, Pages 300-311

  Wilson, Emma H ^a   Harris, Tajie H ^a   Mrass, Paulus ^b   John, Beena ^a   Tait, Elia D ^a   Wu, Gregory F ^a   Pepper, Marion ^a   Wherry, E John ^b   Dzierzinski, Florence ^c   Roos, David ^a   Haydon, Philip G ^d   Laufer, Terri M ^a   Weninger, Wolfgang ^b   Hunter, Christopher A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLIMMUN

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BRAIN CELL; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL MIGRATION; CELL MOTION; CELL POPULATION; CELL STRUCTURE; CELL TRANSFER; CONTROLLED STUDY; EFFECTOR CELL; ENCEPHALITIS; IMMUNE RESPONSE; LEUKOCYTE; LYMPHOCYTE; MICROSCOPY; MOUSE; NONHUMAN; ORIENTATION; PRIORITY JOURNAL; RETICULUM CELL; T LYMPHOCYTE; TOXOPLASMOSIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; MICE; RATS; TOXOPLASMA; TOXOPLASMOSIS, CEREBRAL;

EID: 60149107060     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.12.013     Document Type: Article

References (46)

1. Asperti-Boursin F., Real E., Bismuth G., Trautmann A., and Donnadieu E. CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J. Exp. Med. 204 (2007) 1167-1179
2. Bajenoff M., Egen J.G., Koo L.Y., Laugier J.P., Brau F., Glaichenhaus N., and Germain R.N. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25 (2006) 989-1001
3. Bajenoff M., Egen J.G., Qi H., Huang A.Y., Castellino F., and Germain R.N. Highways, byways and breadcrumbs: Directing lymphocyte traffic in the lymph node. Trends Immunol. 28 (2007) 346-352
4. Barker C.F., and Billingham R.E. Immunologically privileged sites. Adv. Immunol. 25 (1977) 1-54
5. Beltman J.B., Maree A.F., Lynch J.N., Miller M.J., and de Boer R.J. Lymph node topology dictates T cell migration behavior. J. Exp. Med. 204 (2007) 771-780
6. Blanchard N., Gonzalez F., Schaeffer M., Joncker N.T., Cheng T., Shastri A.J., Robey E.A., and Shastri N. Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. Nat. Immunol. 9 (2008) 937-944
7. Bousso P., and Robey E.A. Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy. Immunity 21 (2004) 349-355
8. Campagnola P.J., and Loew L.M. Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms. Nat. Biotechnol. 21 (2003) 1356-1360
9. Cox G., and Kable E. Second-harmonic imaging of collagen. Methods Mol. Biol. 319 (2006) 15-35
10. Cserr H.F., and Knopf P.M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view. Immunol. Today 13 (1992) 507-512
11. Egen J.G., Rothfuchs A.G., Feng C.G., Winter N., Sher A., and Germain R.N. Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas. Immunity 28 (2008) 271-284
12. Fitch M.T., and Silver J. CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp. Neurol. 209 (2008) 294-301
13. Flugel A., Berkowicz T., Ritter T., Labeur M., Jenne D.E., Li Z., Ellwart J.W., Willem M., Lassmann H., and Wekerle H. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 14 (2001) 547-560
14. Frickel E.M., Sahoo N., Hopp J., Gubbels M.J., Craver M.P., Knoll L.J., Ploegh H.L., and Grotenbreg G.M. Parasite stage-specific recognition of endogenous toxoplasma gondii-derived CD8(+) T cell epitopes. J. Infect. Dis. 198 (2008) 1625-1633
15. Friedl P., and Weigelin B. Interstitial leukocyte migration and immune function. Nat. Immunol. 9 (2008) 960-969
16. Galea I., Bernardes-Silva M., Forse P.A., van Rooijen N., Liblau R.S., and Perry V.H. An antigen-specific pathway for CD8 T cells across the blood-brain barrier. J. Exp. Med. 204 (2007) 2023-2030
17. Gazzinelli R., Xu Y., Hieny S., Cheever A., and Sher A. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J. Immunol. 149 (1992) 175-180
18. Geissmann F., Cameron T.O., Sidobre S., Manlongat N., Kronenberg M., Briskin M.J., Dustin M.L., and Littman D.R. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 3 (2005) e113
19. Halin C., Rodrigo Mora J., Sumen C., and von Andrian U.H. In vivo imaging of lymphocyte trafficking. Annu. Rev. Cell Dev. Biol. 21 (2005) 581-603
20. Heck N., Garwood J., Dobbertin A., Calco V., Sirko S., Mittmann T., Eysel U.T., and Faissner A. Evidence for distinct leptomeningeal cell-dependent paracrine and EGF-linked autocrine regulatory pathways for suppression of fibrillar collagens in astrocytes. Mol. Cell. Neurosci. 36 (2007) 71-85
21. Hickman H.D., Takeda K., Skon C.N., Murray F.R., Hensley S.E., Loomis J., Barber G.N., Bennink J.R., and Yewdell J.W. Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes. Nat. Immunol. 9 (2008) 155-165
22. Hunter C.A., and Remington J.S. Immunopathogenesis of toxoplasmic encephalitis. J. Infect. Dis. 170 (1994) 1057-1067
23. Junt T., Moseman E.A., Iannacone M., Massberg S., Lang P.A., Boes M., Fink K., Henrickson S.E., Shayakhmetov D.M., Di Paolo N.C., et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450 (2007) 110-114
24. Kawakami N., Nagerl U.V., Odoardi F., Bonhoeffer T., Wekerle H., and Flugel A. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J. Exp. Med. 201 (2005) 1805-1814
25. Khanna K.M., McNamara J.T., and Lefrancois L. In situ imaging of the endogenous CD8 T cell response to infection. Science 318 (2007) 116-120
26. Medawar P.B. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to anterior chamber of the eye. Br. J. Exp. Pathol. 29 (1948) 58-69
27. Miller M.J., Hejazi A.S., Wei S.H., Cahalan M.D., and Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101 (2004) 998-1003
28. Miller M.J., Wei S.H., Parker I., and Cahalan M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296 (2002) 1869-1873
29. Mrass P., Takano H., Ng L.G., Daxini S., Lasaro M.O., Iparraguirre A., Cavanagh L.L., von Andrian U.H., Ertl H.C., Haydon P.G., and Weninger W. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J. Exp. Med. 203 (2006) 2749-2761
30. Mrass P., and Weninger W. Immune cell migration as a means to control immune privilege: Lessons from the CNS and tumors. Immunol. Rev. 213 (2006) 195-212
31. Norbury C.C., Malide D., Gibbs J.S., Bennink J.R., and Yewdell J.W. Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nat. Immunol. 3 (2002) 265-271
32. Odoardi F., Kawakami N., Li Z., Cordiglieri C., Streyl K., Nosov M., Klinkert W.E., Ellwart J.W., Bauer J., Lassmann H., et al. Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 104 (2007) 920-925
33. Okada T., and Cyster J.G. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J. Immunol. 178 (2007) 2973-2978
34. Pepper M., Dzierszinski F., Crawford A., Hunter C.A., and Roos D. Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis. Infect. Immun. 72 (2004) 7240-7246
35. Reichmann G., Villegas E.N., Craig L., Peach R., and Hunter C.A. The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology. J. Immunol. 163 (1999) 3354-3362
36. Sharpe A.H., Wherry E.J., Ahmed R., and Freeman G.J. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8 (2007) 239-245
37. Stoll S., Delon J., Brotz T.M., and Germain R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296 (2002) 1873-1876
38. Tessier-Lavigne M., and Goodman C.S. The molecular biology of axon guidance. Science 274 (1996) 1123-1133
39. Wherry E.J., Ha S.J., Kaech S.M., Haining W.N., Sarkar S., Kalia V., Subramaniam S., Blattman J.N., Barber D.L., and Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27 (2007) 670-684
40. Wilson E.H., Wille-Reece U., Dzierszinski F., and Hunter C.A. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J. Neuroimmunol. 165 (2005) 63-74
41. Worbs T., Mempel T.R., Bolter J., von Andrian U.H., and Forster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204 (2007) 489-495
42. Yang B.G., Tanaka T., Jang M.H., Bai Z., Hayasaka H., and Miyasaka M. Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: Its implications in lymphocyte trafficking. J. Immunol. 179 (2007) 4376-4382
43. Yasui T., Tohno Y., and Araki T. Determination of collagen fiber orientation in human tissue by use of polarization measurement of molecular second-harmonic-generation light. Appl. Opt. 43 (2004) 2861-2867
44. Yednock T.A., Cannon C., Fritz L.C., Sanchez-Madrid F., Steinman L., and Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 356 (1992) 63-66
45. Zhuo L., Sun B., Zhang C.L., Fine A., Chiu S.Y., and Messing A. Live astrocytes visualized by green fluorescent protein in transgenic mice. Dev. Biol. 187 (1997) 36-42
46. Zinselmeyer B.H., Dempster J., Gurney A.M., Wokosin D., Miller M., Ho H., Millington O.R., Smith K.M., Rush C.M., Parker I., et al. In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J. Exp. Med. 201 (2005) 1815-1823