Feed development for fed-batch CHO production process by semisteady state analysis

Biotechnology Progress

Volumn 26, Issue 3, 2010, Pages 797-804

  Khattak, Sarwat F ^a   Xing, Zizhuo ^a   Kenty, Brian ^a   Koyrakh, Inna ^b   Li, Zheng Jian ^a  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Cell culture; Feeding strategy and continuous mode; Glucose and glutamine metabolism

Indexed keywords

AMINO ACID PRODUCTION; AMMONIA PRODUCTION; CELL PHYSIOLOGY; CHO CELL; CONSTANT VOLUMES; CONTINUOUS MODE; CONTINUOUS PROCESS IMPROVEMENT; FED BATCHES; FED-BATCH PROCESS; FEEDING STRATEGIES; GLUCOSE LEVEL; IN-CELL; LOW LEVEL; PROCESS CONSISTENCY; PRODUCTION PROCESS; STATE ANALYSIS; VIABLE CELLS;

AMINO ACIDS; AMMONIA; BATCH DATA PROCESSING; CELL CULTURE; FEEDING; GLUCOSE; GROWTH KINETICS; METABOLISM; ORGANIC ACIDS; PHYSIOLOGY;

CONTINUOUS CELL CULTURE;

AMMONIA; GLUCOSE; GLUTAMINE; LACTIC ACID; CULTURE MEDIUM;

ANIMAL; ARTICLE; BIOREACTOR; CELL COUNT; CELL SURVIVAL; CHO CELL; CRICETULUS; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; HAMSTER; METABOLISM; METHODOLOGY; CHO CELL LINE; PROCEDURES;

AMMONIA; ANIMALS; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; GLUCOSE; GLUTAMINE; LACTIC ACID;

EID: 77954718030     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.362     Document Type: Article

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