In vivo T-cell dynamics during immune reconstitution after hematopoietic stem cell gene therapy in adenosine deaminase severe combined immune deficiency

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 6, 2011, Pages

  Selleri, Silvia ^a   Brigida, Immacolata ^a,d   Casiraghi, Miriam ^a,b   Scaramuzza, Samantha ^a,c   Cappelli, Barbara ^b   Cassani, Barbara ^a,c   Ferrua, Francesca ^b   Aker, Memet ^e   Slavin, Shimon ^e   Scarselli, Alessia ^d   Cancrini, Caterina ^d   Marktel, Sarah ^b   Grazia Roncarolo, Maria ^a,b   Aiuti, Alessandro ^a,b,d  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

ADA SCID; cell cycle; Gene therapy; immune reconstitution; senescence

Indexed keywords

ADENOSINE DEAMINASE; BUSULFAN; CD34 ANTIGEN; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CELL COMPARTMENTALIZATION; CELL EXPANSION; CELL FRACTIONATION; CELL PROLIFERATION; CELL SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EXCISION REPAIR; GENE REPLICATION; GENE THERAPY; GRANULOCYTE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VIVO GENE TRANSFER; IN VIVO STUDY; MEMORY T LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; SEVERE COMBINED IMMUNODEFICIENCY; T LYMPHOCYTE; TELOMERE;

EID: 79957838337     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.03.004     Document Type: Article

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