The processing of nanoparticles containing protein for suspension in hydrofluoroalkane propellants

International Journal of Pharmaceutics

Volumn 372, Issue 1-2, 2009, Pages 140-146

  Nyambura, Bildad K ^a   Kellaway, Ian W ^a   Taylor, Kevin M G ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Aerosol; Hydrofluroalkane; Lysozyme; Nanoparticle; Pressurized metered dose inhaler; Protein

Indexed keywords

ALCOHOL; CHLOROFORM; FLUORINATED HYDROCARBON; LACTOSE; LYSOZYME; NANOPARTICLE; PHOSPHATIDYLCHOLINE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; METERED DOSE INHALER; MICROEMULSION; PRIORITY JOURNAL;

AEROSOL PROPELLANTS; HYDROCARBONS, FLUORINATED; NANOPARTICLES; PARTICLE SIZE; PROTEINS; SUSPENSIONS;

EID: 64149116680     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.01.005     Document Type: Article

References (22)

1. Barichello J.M., Morishita M., Takayama K., and Nagai T. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev. Ind. Pharm. 25 (1999) 471-476
2. In: Benita S. (Ed). Submicron Emulsions in Drug Targeting and Delivery (1998), Harwood Academic Publishers, Amsterdam
3. Cook R.O., Pannu R.K., and Kellaway I.W. Novel sustained release microspheres for pulmonary drug delivery. J. Control. Rel. 104 (2005) 79-90
4. Dickinson P.A., Howells S.W., and Kellaway I.W. Novel nanoparticles for pulmonary administration. J. Drug Target. 9 (2001) 295-302
5. Doelker E., Allémann E., and Bilati U. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur. J. Pharm. Sci. 24 (2005) 67-75
6. Fessi H., Puisieux F., Deissaguet J.P., Ammoury N., and Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55 (1989) R1-R4
7. Govender T., Stolnik S., Garnett M.C., Illum L., and Davis S.S. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water-soluble drug. J. Control. Rel. 57 (1999) 171-185
8. Gunning P.A., Mackie A.R., Gunning A.P., Woodward N.C., Wilde P.J., and Morris V.J. Effect of surfactant type on surfactant-protein interactions at the air-water interface. Biomacromolecules 5 (2004) 984-991
9. Keck C.M., and Muller R.H. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. Eur. J. Pharm. Biopharm. 62 (2006) 3-16
10. Kelley D., and McClements D.J. Interactions of bovine serum albumin with ionic surfactants in aqueous solutions. Food Hydrocolloids 17 (2003) 73-85
11. Kesisoglou F., Panmai S., and Wu Y. Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv. Drug Deliv. Rev. 59 (2007) 631-644
12. Liao Y.-H., Brown M.B., Nazir T., Quader A., and Martin G.P. Effects of sucrose and trehalose on the preservation of the native structure of spray-dried lysozyme. Pharm. Res. 19 (2002) 1847-1853
13. Liao Y.H., Brown M.B., Jones S.A., Nazir T., and Martin G.P. The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers. Int. J. Pharm. 304 (2005) 29-39
14. McClements D.J. Protein-stabilized emulsions. Curr. Opin. Colloid Interf. Sci. 9 (2004) 305-313
15. Merisko-Liversidge E., Liversidge G.G., and Cooper E.R. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur. J. Pharm. Sci. 18 (2003) 113-120
16. Quinn E.A., Forbes R.T., Williams A.C., Oliver M.J., McKenzie L., and Purewal T.S. Protein conformational stability in the hydrofluoroalkane propellants tetrafluoroethane and heptafluoropropane analysed by Fourier transform Raman spectroscopy. Int. J. Pharm. 186 (1999) 31-41
17. Rabinow B.E. Nanosuspensions in drug delivery. Nat. Rev. Drug Discov. 3 (2004) 785-796
18. Ridder, K.B., 2004. Nanoparticle formulations in HFA propellants. PhD Thesis. The School of Pharmacy, University of London, London.
19. Stevenson C.L. Characterization of protein and peptide stability and solubility in non-aqueous solvents. Curr. Pharm. Biotechnol. 49 (2000) 859-866
20. Tsapis N., Bennett D., Jackson B., Weitz D.A., and Edwards D.A. Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12001-12005
21. Wilde P.J., Mackie A.R., Husband F.H., Gunning A.P., and Morris V.J. Proteins and emulsifiers at liquid interfaces. Adv. Coll. Polymer Sci. 108-9 (2004) 63-71
22. Williams III R.O., and Liu J. Formulation of a protein with propellant HFA 134a for aerosol delivery. Eur. J. Pharm. Sci. 7 (1999) 137-144