Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation

Molecular Endocrinology

Volumn 25, Issue 6, 2011, Pages 995-1005

  Inoue, Jun ^a   Yamasaki, Kohei ^a   Ikeuchi, Emina ^a   Satoh, Shin Ichi ^a   Fujiwara, Yoko ^b   Nishimaki Mogami, Tomoko ^c   Shimizu, Makoto ^a   Sato, Ryuichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OCHANOMIZU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BINDING PROTEIN; FATTY ACID; GLUCOSE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MIDLINE 1 INTERACTING G12 LIKE PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOHYDRATE RESPONSE ELEMENT 1; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN RESPONSIVE ELEMENT; DNA STRUCTURE; FATTY ACID SYNTHESIS; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; LIPOGENESIS; LIVER CELL; LIVER X RECEPTOR RESPONSIVE ELEMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BASE SEQUENCE; CELLS, CULTURED; FATTY ACIDS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEK293 CELLS; HEPATOCYTES; HUMANS; HYDROCARBONS, FLUORINATED; LIPOGENESIS; LUCIFERASES; MALE; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; ORPHAN NUCLEAR RECEPTORS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

MUS; RATTUS;

EID: 79957668605     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-0070     Document Type: Article

References (37)

1. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ 1995 LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9:1033-1045
2. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ 1996 An oxysterol signalling pathway mediated by the nuclear receptor LXR. Nature 383:728-731
3. Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW 2007 Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 5:73-79
4. Zelcer N, Tontonoz P 2006 Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-614
5. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P 2002 Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci USA 99:7604-7609
6. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P 2003 Activation of liver X receptor improves glucose tol-erance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 100:5419-5424
7. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B 2000 Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838
8. Berti C, Fontanella B, Ferrentino R, Meroni G 2004 Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. BMC Cell Biol 5:9
9. Zhu Q, Anderson GW, Mucha GT, Parks EJ, Metkowski JK, Mariash CN 2005 The Spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland. Endocrinology 146: 3343-3350
10. Nishi N, Shoji H, Miyanaka H, Nakamura T 2008 Transient upregulation of a novel member of Spot 14 family in androgen-stimulated rat prostate. Biochim Biophys Acta 1780:1004-1009
11. Jump DB, Oppenheimer JH 1985 High basal expression and 3,5,3- triiodothyronine regulation of messenger ribonucleic acid S14 in lipogenic tissues. Endocrinology 117:2259-2266
12. Kinlaw WB, Schwartz HL, Towle HC, Oppenheimer JH 1986 Opposing effects of glucagon and triiodothyronine on the hepatic levels of messenger ribonucleic acid S14 and the dependence of such effects on circadian factors. J Clin Invest 78:1091-1096
13. Zhu Q, Mariash A, Margosian MR, Gopinath S, Fareed MT, Anderson GW, Mariash CN 2001 Spot 14 gene deletion increases hepatic de novo lipogenesis. Endocrinology 142:4363-4370
14. Aipoalani DL, O'Callaghan BL, Mashek DG, Mariash CN, Towle HC 2010 Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis. Endocrinology 151:2071-2077
15. Kim CW, Moon YA, Park SW, Cheng D, Kwon HJ, Horton JD 2010 Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc Natl Acad Sci USA 107:9626-9631
16. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ 2000 Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev 14:2819-2830
17. Cha JY, Repa JJ 2007 The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 282:743-751
18. Inoue J, Satoh S, Kita M, Nakahara M, Hachimura S, Miyata M, Nishimaki-Mogami T, Sato R 2008 PPAR gene expression is upregulated by LXR and PXR activators in the small intestine. Biochem Biophys Res Commun 371:675-678
19. Mitro N, Vargas L, Romeo R, Koder A, Saez E 2007 T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Lett 581:1721-1726
20. Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP 2004 T0901317 is a dual LXR/FXR agonist. Mol Genet Metab 83:184-187
21. Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C 2004 Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem 279:20314- 20326
22. Tsatsos NG, Augustin LB, Anderson GW, Towle HC, Mariash CN 2008 Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate. Endocrinology 149:5155-5161
23. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL 2003 Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100:12027-12032
24. Foretz M, Guichard C, Ferré P, Foufelle F 1999 Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 96:12737-12742
25. Kim SY, Kim HI, Kim TH, Im SS, Park SK, Lee IK, Kim KS, AhnYH 2004 SREBP-1c mediates the insulin-dependent hepatic glucokinase expression. J Biol Chem 279:30823-30829
26. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ 2000 Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6:507-515
27. Luo Y, Liang CP, Tall AR 2001 The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem 276:24767-24773
28. Matsukuma KE, Wang L, Bennett MK, Osborne TF 2007 A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor. J Biol Chem 282:20164-20171
29. Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzales FJ 2000 Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102:731-744
30. Berry MN, Friend DS 1969 High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 43:506-520
31. Higuchi R, Krummel B, Saiki RK 1988 A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res 16:7351-7367
32. Arimura N, Horiba T, Imagawa M, Shimizu M, Sato R 2004 The peroxisome proliferator-activated receptor regulates expression of the perilipin gene in adipocytes. J Biol Chem 279:10070-10076
33. Schmidt DR, Holmstrom SR, Fon Tacer K, Bookout AL, Kliewer SA, Mangelsdorf DJ 2010 Regulation of bile acid synthesis by fatsoluble vitamins A and D. J Biol Chem 285:14486-14494
34. Kanayama T, Arito M, So K, Hachimura S, Inoue J, Sato R 2007 Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities. J Biol Chem 282:10290-10298
35. Sato R, Miyamoto W, Inoue J, Terada T, Imanaka T, Maeda M 1999 Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription. J Biol Chem 274:24714-24720
36. Yamada K, Tanaka T, Noguchi T 1997 Members of the nuclear factor 1 family and hepatocyte nuclear factor 4 bind to overlapping sequences of the L-II element on the rat pyruvate kinase L gene promoter and regulate its expression. Biochem J 324:917-925
37. Takahashi Y, Ohoka N, Hayashi H, Sato R 2008 TRB3 suppresses adipocyte differentiation by negatively regulating PPAR transcriptional activity. J Lipid Res 49:880-892