Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure

Food and Chemical Toxicology

Volumn 49, Issue 7, 2011, Pages 1584-1591

  Al Dissi, Ahmad N ^a   Weber, Lynn P ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Cytochrome P450 1A1 activity; Endothelial dysfunction; Environmental tobacco smoke; Oxidative stress; Pulmonary inflammation; Resveratrol

Indexed keywords

3 NITROTYROSINE; C REACTIVE PROTEIN; CIGARETTE SMOKE; CYTOCHROME P450 1A1; LEUKOCYTE ELASTASE; MEGARESVERATROL; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CASTRATED MALE; CONTROLLED STUDY; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL EXPOSURE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HISTOPATHOLOGY; JUVENILE ANIMAL; LEUKOCYTE COUNT; LUNG LAVAGE; MALE; NONHUMAN; PASSIVE SMOKING; PNEUMONIA; SWINE;

ADMINISTRATION, ORAL; ANIMALS; AORTA, ABDOMINAL; BLOOD PRESSURE; BRONCHOALVEOLAR LAVAGE FLUID; C-REACTIVE PROTEIN; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; COTININE; CYTOCHROME P-450 CYP1A1; ECHOCARDIOGRAPHY; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL EXPOSURE; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; MALE; NITRATES; NITRITES; OXIDATIVE STRESS; STILBENES; SWINE; TOBACCO SMOKE POLLUTION; TYROSINE; VENTRICULAR FUNCTION, LEFT;

NICOTIANA TABACUM; SUIDAE;

EID: 79957667931     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.04.005     Document Type: Article

References (58)

1. Ahmad K.A., Clement M.V., Pervaiz S. Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide-induced apoptosis. Ann. NY Acad. Sci. 2003, 1010:365-373.
2. Alam M., Samad B.A., Wardell J., Andersson E., Hoglund C., Nordlander R. Acute effects of smoking on diastolic function in healthy participants: studies by conventional doppler echocardiography and doppler tissue imaging. J. Am. Soc. Echocardiogr. 2002, 15:1232-1237.
3. Alberg A.J. Cigarette smoking: health effects and control strategies. Drugs Today (Barc.) 2008, 44:895-904.
4. Antoniades C., Tousoulis D., Vasiliadou C., Marinou K., Tentolouris C., Ntarladimas I., Stefanadis C. Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response. Am. J. Cardiol. 2004, 94:1181-1184.
5. Anttila S., Tuominen P., Hirvonen A., Nurminen M., Karjalainen A., Hankinson O., Elovaara E. CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor. Pharmacogenetics 2001, 11:501-509.
6. Beher D., Wu J., Cumine S., Kim K.W., Lu S.C., Atangan L., Wang M. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 2009, 74:619-624.
7. Bhalla D.K., Hirata F., Rishi A.K., Gairola C.G. Cigarette smoke, inflammation, and lung injury: a mechanistic perspective. J. Toxicol. Environ. Health B Crit. Rev. 2009, 12:45-64.
8. Borland C., Harmes K., Cracknell N., Mack D., Higenbottam T. Methemoglobin levels in smokers and non-smokers. Arch. Environ. Health 1985, 40:330-333.
9. Canistro D., Bonamassa B., Pozzetti L., Sapone A., Abdel-Rahman S.Z., Biagi G.L., Paolini M. Alteration of xenobiotic metabolizing enzymes by resveratrol in liver and lung of CD1 mice. Food Chem. Toxicol. 2009, 47:454-461.
10. Casper R.F., Quesne M., Rogers I.M., Shirota T., Jolivet A., Milgrom E., Savouret J.F. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol. Pharmacol. 1999, 56:784-790.
11. Castillo M.J., Nakajima K., Zimmerman M., Powers J.C. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal. Biochem. 1979, 99:53-64.
12. Chan-Yeung M., Dimich-Ward H. Respiratory health effects of exposure to environmental tobacco smoke. Respirology 2003, 8:131-139.
13. Chen C.Y., Chow D., Chiamvimonvat N., Glatter K.A., Li N., He Y., Pinkerton K.E., Bonham A.C. Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice. Am. J. Physiol. Heart Circ. Physiol. 2008, 295:632-639.
14. Celermajer D.S., Adams M.R., Clarkson P., Robinson J., McCredie R., Donald A., Deanfield J.E. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N. Engl. J. Med. 1996, 334:150-155.
15. Csiszar A., Labinskyy N., Podlutsky A., Kaminski P.M., Wolin M.S., Zhang C., Mukhopadhyay P., Pacher P., Hu F., de Cabo R., Ballabh P., Ungvari Z. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am. J. Physiol. Heart Circ. Physiol. 2008, 294:H2721-2735.
16. Ding Y.S., Zhang L., Jain R.B., Jain N., Wang R.Y., Ashley D.L., Watson C.H. Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties. Canc. Epidem. Biomarkers Prev. 2008, 17:3366-3371.
17. Donnelly L.E., Newton R., Kennedy G.E., Fenwick P.S., Leung R.H.F., Ito K., Russell R.E.K., Barnes P.J. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 287:L774-783.
18. El-Attar T.M., Virji A.S. Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs 1999, 10:187-193.
19. Fujii T., Hayashi S., Hogg J.C., Mukae H., Suwa T., Goto Y., Vincent R., van Eeden S.F. Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. Am. J. Respir. Cell Mol. Biol. 2002, 27:34-41.
20. Gan W.Q., Man S.F.P., Sin D.D. The interactions between cigarette smoking and reduced lung function on systemic inflammation. Chest 2005, 127:558-564.
21. Gentner N.J., Weber L.P. Using blood pressure telemetry to assess acute changes in arterial stiffness in rats after nitric oxide synthase inhibition or environmental tobacco smoke exposure. Can. J. Physiol. Pharmacol. 2010, 88:918-928.
22. Green D. Point: flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J. Appl. Physiol. 2005, 99:1233-1234. (discussion 1237-1238).
23. Gulel O., Soylu K., Yazici M., Demircan S., Durna K., Sahin M. Longitudinal diastolic myocardial functions are affected by chronic smoking in young healthy people: a study of color tissue Doppler imaging. Echocardiography 2007, 24:494-498.
24. Jin A.S., Hyunah L., Yoo-Kyoung L., Yaekyu K., Ji Ha C., Eun-Mi P. Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke. J. Neuroimmun. 2010, 227:93-100.
25. Karatzi K., Karatzis E., Papamichael C., Lekakis J., Zampelas A. Effects of red wine on endothelial function: post-prandial versus clinical trials. Nutr. Metab. Cardiovasc. Dis. 2009, 19:744-750.
26. Karatzi K., Papamichael C., Karatzis E., Papaioannou T.G., Voidonikola P.T., Lekakis J., Zampelas A. Acute smoking induces endothelial dysfunction in healthy smokers. Is this reversible by red wine's antioxidant constituents?. J. Am. Coll. Nutr. 2007, 26:10-15.
27. Kawada N., Seki S., Inoue M., Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 1998, 27:1265-1274.
28. Korashy H.M., El-Kadi A.O.S. The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases. Drug Metab. Rev. 2006, 38:411-450.
29. Lekli I., Szabo G., Juhasz B., Das S., Das M., Varga E., Szendrei L., Gesztelyi R., Varadi J., Bak I., Das D.K., Tosaki A. Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin. Am. J. Physiol. Heart Circ. Physiol. 2008, 294:H859-866.
30. Lucattelli M., Bartalesi B., Cavarra E., Fineschi S., Lunghi B., Martorana P.A., Lungarella G. Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. Respir. Res. 2005, 6:83.
31. Maeno T., Houghton A.M., Quintero P.A., Grumelli S., Owen C.A., Shapiro S.D. CD8+ T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J. Immunol. 2007, 178:8090-8096.
32. May A., Wang T.J. Evaluating the role of biomarkers for cardiovascular risk prediction: focus on CRP, BNP and urinary microalbumin. Expert Rev. Mol. Diagn. 2007, 7:793-804.
33. Meurrens K., Ruf S., Ross G., Schleef R., von Holt K., Schlacter K.D. Smoking accelerates the progression of hypertension-induced myocardial hypertrophy to heart failure in spontaneously hypertensive rats. Cardiovasc. Res. 2007, 76:311-322.
34. Moorthy B., Miller K.P., Jiang W., Williams E.S., Kondraganti S.R., Ramos K.S. Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates. J. Pharmacol. Exp. Ther. 2003, 305:394-401.
35. Mukherjee S., Dudley J.I., Das D.K. Dose-dependency of resveratrol in providing health benefits. Dose-Response 2010, 8:478-500.
36. Pacholec M., Bleasdale J.E., Chrunyk B., Cunningham D., Flynn D., Garofalo R.S., Griffith D., Griffor M., Loulakis P., Pabst B., Qiu X., Stockman B., Thanabal V., Varghese A., Ward J., Withka J., Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 2010, 285:8340-8351.
37. Palsamy P., Sivakumar S., Subramanian S. Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. Chem. Biol. Interact. 2010, 186:200-210.
38. Peluffo G., Calcerrada P., Piacenza L., Pizzano N., Radi R. Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H1781-1792.
39. Penumathsa S., Koneru S., Samuel S.M., Zhan L., Menon V.P., Maulik N. Red wine polyphenol resveratrol regulates heme oxygenase-1 conversely for the disruption of Caveolin-1/eNOS platform and improves left ventricular function in ischemic hypercholesterolemic nyocardium. FASEB J. 2008, 22:1113-1130.
40. Rahman M.M., Laher I. Structural and functional alteration of blood vessels caused by cigarette smoking: an overview of molecular mechanisms. Curr. Vasc. Pharmacol. 2007, 5:276-292.
41. Renaud S., de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992, 339:1523-1526.
42. Rocha K.K., Souza G.A., Ebaid G.X., Seiva F.R., Cataneo A.C., Novelli E.L. Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem. Toxicol. 2009, 47:1362-1367.
43. Salvi S.S., Barnes P.J. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009, 374:733-743.
44. Sharafkhaneh A., Hanania N.A., Kim V. Pathogenesis of emphysema: from the bench to the bedside. Proc. Am. Thorac. Soc. 2008, 5:475-477.
45. Silvia B., Elisabet A., Gemma F., Mireia O., Viktoria R., Josep M.A., Francisco J.L. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. Canc. Lett. 2007, 245:144-148.
46. Taddei S., Caraccio N., Virdis A., Dardano A., Versari D., Ghiadoni L., Ferrannini E., Salvetti A., Monzani F. Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis. J. Clin. Endocrinol. Metab. 2006, 91:5076-5082.
47. Thom S.R., Xu Y.A., Ischiropoulos H. Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure. Chem. Res. Toxicol. 1997, 10:1023-1031.
48. Tithof P.K., Elgayyar M., Cho Y., Guan W.E.I., Fisher A.B., Peters-Golden M. Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J. 2002, 16:1463-1464.
49. Turrens J.F., Lariccia J., Nair M.G. Resveratrol has no effect on lipoprotein profile and does not prevent peroxidation of serum lipids in normal rats. Free Rad. Res. 1997, 27:557-562.
50. van der Vaart H., Postma D.S., Timens W., Ten Hacken N.H.T. Acute effects of cigarette smoke on inflammation and oxidative stress: a review. Thorax 2004, 59:713-721.
51. Walle T., Hsieh F., DeLegge M.H., Oatis J.E., Walle U.K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 2004, 32:1377-1382.
52. Wang Z., Zou J., Cao K., Hsieh T.C., Huang Y., Wu J.M. Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels. Int. J. Mol. Med. 2005, 16:533-540.
53. Weber L.P., Diamond S.L., Bandiera S.M., Janz D.M. Expression of HSP70 and CYP1A protein in ovary and liver of juvenile rainbow trout exposed to beta-naphthoflavone. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2002, 131:387-394.
54. Wilson T., Knight T.J., Beitz D.C., Lewis D.S., Engen R.L. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996, 59:PL15-PL21.
55. Wong, R.H., Howe, P.R., Buckley, J.D., Coates, A.M., Kunz, I., Berry, N.M., 2010. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. doi:10.1016/j.numecd.2010.03.003.
56. Wright R.O., Lewander W.J., Woolf A.D. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann. Emerg. Med. 1999, 34:646-656.
57. Wu J.M., Hsieh T.C. Resveratrol: a cardioprotective substance. Ann. NY Acad. Sci. 2011, 1215:16-21.
58. Zhang W.-Z., Venardos K., Chin-Dusting J., Kaye D.M. Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress. Hypertension 2006, 48:278-285.