Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells

Photochemical and Photobiological Sciences

Volumn 8, Issue 10, 2009, Pages 1461-1466

  Feuerstein, Tamar ^a   Schauder, Avital ^a   Malik, Zvi ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FLUORESCEIN ISOTHIOCYANATE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; PHOTOSENSITIZING AGENT; PORPHOBILINOGEN SYNTHASE; PROTOPORPHYRIN; SHORT HAIRPIN RNA;

ARTICLE; CELL DAMAGE; CELL DEATH; CELL MEMBRANE; CELL PROTECTION; CELL STRAIN K 562; CELL STRUCTURE; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; ENZYME ACTIVITY; ERYTHROLEUKEMIA CELL; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRION; PHOTODYNAMIC THERAPY; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; THERAPY EFFECT;

EID: 70349785718     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/b9pp00007k     Document Type: Article

References (17)

1. G. Berkovitch D. Doron A. Nudelman Z. Malik A. Rephaeli Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation J. Med. Chem. 2008 51 7356 7369
2. M. J. Gerritsen T. Smits M. M. Kleinpenning P. C. van de Kerkhof P. E. van Erp Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy Dermatology 2009 218 193 202
3. S. L. Gibson J. J. Havens L. Metz R. Hilf Is δ-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to δ-aminolevulinic acid? Photochem. Photobiol. 2001 73 312 317
4. L. Greenbaum Y. Gozlan D. Schwartz D. J. Katcoff Z. Malik Nuclear distribution of porphobilinogen deaminase (PBGD) in glioma cells: a regulatory role in cancer transformation? Br. J. Cancer 2002 86 1006 1011
5. B. Grinblat N. Pour Z. Malik Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication J. Environ. Pathol., Toxicol. Oncol. 2006 25 145 158
6. N. Grunberg-Etkovitz L. Greenbaum B. Grinblat Z. Malik Proteasomal degradation regulates expression of porphobilinogen deaminase (PBGD) mutants of acute intermittent porphyria Biochim. Biophys. Acta, Mol. Basis Dis. 2006 1762 819 827
7. G. G. Guo M. Gu J. D. Etlinger 240-kDa proteasome inhibitor (CF-2) is identical to δ-aminolevulinic acid dehydratase J. Biol. Chem. 1994 269 12399 12402
8. M. Hrdinka H. Puy P. Martasek May 2006 update in porphobilinogen deaminase gene polymorphisms and mutations causing acute intermittent porphyria: comparison with the situation in Slavic population Physiol. Res. 2006 55 Suppl 2 S119 S136
9. S. D. Ickowicz Y. Gozlan L. Greenbaum T. Babushkina D. J. Katcoff Z. Malik Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma Br. J. Cancer 2004 90 1833 1841
10. E. K. Jaffe L. Stith ALAD porphyria is a conformational disease Am. J. Hum. Genet. 2007 80 329 337
11. R. Kauppinen Porphyrias Lancet 2005 365 241 252
12. A. Klein P. Babilas S. Karrer M. Landthaler R. M. Szeimies Photodynamic therapy in dermatology - an update 2008 J. Dtsch. Dermatol. Ges. 2008 6 839 846
13. P. N. Liubchenko B. N. Gladyshev V. F. Mostun Porphobilinogen biosynthesis from δ-aminolevulinic acid by the internal organs of white rats Biul. Eksp. Biol. Med. 1978 86 687 689
14. M. Miyake M. Ishii K. Kawashima T. Kodama K. Sugano K. Fujimoto Y. Hirao siRNA-mediated Knockdown of the Heme Synthesis and Degradation Pathways: Modulation of Treatment Effect of 5-Aminolevulinic Acid-based Photodynamic Therapy in Urothelial Cancer Cell Lines Photochem. Photobiol. 2009 85 1020 1027
15. N. M. Navone C. F. Polo A. L. Frisardi A. M. Batlle Mouse mammary carcinoma δ-aminolevulinate dehydratase Comp. Biochem. Physiol., Part B: Biochem. Mol. Biol. 1990 96 729 731
16. P. Ponka Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells Blood 1997 89 1 25
17. P. Ponka H. M. Schulman Regulation of heme biosynthesis: distinct regulatory features in erythroid cells Stem Cells 1993 11 s1 24 35