Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins)

Journal of Biological Chemistry

Volumn 281, Issue 10, 2006, Pages 6682-6690

  Tang, Lei ^a   Breinig, Sabine ^a   Stith, Linda ^a   Mischel, Adele ^a   Tannir, Justin ^a   Kokona, Bashkim ^b   Fairman, Robert ^b   Jaffe, Eileen K ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b HAVERFORD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DIMERS; ENZYME KINETICS; REACTION KINETICS; STOICHIOMETRY;

HUMAN PORPHOBILINOGEN SYNTHASES; OLIGOMERIC ASSEMBLY; QUATERNARY ASSEMBLIES; REVERSIBLE CONVERSION;

MUTAGENESIS;

AMINO ACID; ISOENZYME; MORPHEEIN DERIVATIVE ENZYME; PORPHOBILINOGEN SYNTHASE; UNCLASSIFIED DRUG; ARGININE; TRYPTOPHAN;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DYNAMICS; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME STRUCTURE; GEL ELECTROPHORESIS; HUMAN; LIGHT SCATTERING; MOLECULAR WEIGHT; MUTATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; ULTRACENTRIFUGATION; WILD TYPE; AGAR GEL ELECTROPHORESIS; AMINO ACID SUBSTITUTION; CHEMISTRY; GEL CHROMATOGRAPHY; GENETICS; KINETICS; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; ARGININE; CHROMATOGRAPHY, AGAROSE; ELECTROPHORESIS, AGAR GEL; HUMANS; ISOENZYMES; KINETICS; MUTATION; PORPHOBILINOGEN SYNTHASE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; TRYPTOPHAN;

EID: 33646570009     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511134200     Document Type: Article

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