Synthesis and biological evaluation of loxoprofen derivatives

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3299-3311

  Yamakawa, Naoki ^a   Suemasu, Shintaro ^a   Matoyama, Masaaki ^a   Tanaka, Ken Ichiro ^a   Katsu, Takashi ^b   Miyata, Keishi ^a   Okamoto, Yoshinari ^a   Otsuka, Masami ^a   Mizushima, Tohru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

COX 2 specificity; Gastric lesions; Gastric mucosal cells; Loxoprofen; Membrane permeabilization

Indexed keywords

2 [2 HALOGENO 4 [(2 OXOCYCLOPENTYL)METHYL]PHENYL]PROPANOIC ACID; 2 [2 NITRO 4 [(2 OXOCYCLOPENTYL)METHYL]PHENYL]PROPANOIC ACID; 2 [4' HYDROXY 5 [(2 OXOCYCLOPENTYL)METHYL]BIPHENYL 2 YL]PROPANOIC ACID; 2 BROMOLOXOPROFEN; 2 CHLORO 4 METHYLBENZALDEHYDE; 2 CHLORO 4 METHYLPHENYLACETIC ACID; 2 FLUOROLOXOPROFEN; 2 IODO 3 METHYLPHENYLACETIC ACID; 2 IODO 4 METHYLBENZALDEHYDE; 4 METHYL 2 NITROBENZALDEHYDE; 4 METHYL 2 NITROPHENYLACETIC ACID; CELECOXIB; LOXOPROFEN; METHYL 1 [2 BROMO 4 (1 METHOXY 1 OXOPROPAN 2 YL)BENZYL] 2 OXOCYCLOPENTANECARBOXYLIC ACID; METHYL 1 [3 CHLORO 4 (1 METHOXY 1 OXOPROPAN 2 YL)BENZYL] 2 OXOCYCLOPENTANECARBOXYLIC ACID; METHYL 1 [3 IODO 4 (1 METHOXY 1 OXOPROPAN 2 YL)BENZYL] 2 OXOCYCLOPENTANECARBOXYLIC ACID; METHYL 1 [4 (1 METHOXY 1 OXOPROPAN 2 YL) 3 NITROBENZYL] 2 OXOCYCLOPENTANECARBOXYLIC ACID; METHYL 2 (2 CHLORO 4 METHYLPHENYL)PROPANOIC ACID; METHYL 2 (2 IODO 4 METHYLPHENYL)PROPANOIC ACID; METHYL 2 (3 BROMOPHENYL)PROPANOIC ACID; METHYL 2 (4 METHYL 2 NITROPHENYL)PROPANOIC ACID; METHYL 2 [3 BROMO 4 (CHLOROMETHYL)PHENYL]PROPANOIC ACID; ROFECOXIB; SODIUM 2 [2 CHLORO 4 [(2 OXOCYCLOPENTYL)METHYL]PHENYL]PROPANOIC ACID; SODIUM 2 [2 IODO 4 [(2 OXOCYCLOPENTYL)METHYL]PHENYL]PROPANOIC ACID; SODIUM 2 [2 NITRO 4 [(2 OXOCYCLOPENTYL)METHYL]PHENYL]PROPANOIC ACID; SODIUM 2 [4' METHOXY 5 [(2 OXOCYCLOPENTYL)METHYL]BIPHENYL 2 YL]PROPANOIC ACID; SODIUM 2 [5 [(2 OXOCYCLOPENTYL)METHYL]BIPHENYL 2 YL]PROPANOIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALDECOXIB;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CONTROLLED STUDY; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; DECARBOXYLATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; FOOT EDEMA; HYDROLYSIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH MUCOSA; STOMACH PARIETAL CELL; SUZUKI REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GASTRIC MUCOSA; PHENYLPROPIONATES; RATS;

RATTUS;

EID: 79957493051     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.050     Document Type: Article

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