Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 7044-7050

  Zarghi, Afshin ^a   Zebardast, Tannaz ^a   Hakimion, Farinaz ^a   Shirazi, Farshad H ^a   Praveen Rao, P N ^b   Knaus, Edward E ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Azido pharmacophore; Cyclooxygenase inhibition; Propenone moiety

Indexed keywords

1 (4 AZIDOPHENYL) 3 (4 METHYLPHENYL)PROP 2 EN 1 ONE; 1 (4 METHANESULFONAMIDOPHENYL) 3 (4 METHYLPHENYL)PROP 2 EN 1 ONE; 1,3 DIPHENYLPROP 2 EN 1 ONE DERIVATIVE; ARGININE; AZIDE; BENZENE DERIVATIVE; CHALCONE DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; HISTIDINE; MESYLIC ACID DERIVATIVE; PHENYLALANINE; ROFECOXIB; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BINDING SITE; CLAISEN CONDENSATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZIDES; BINDING SITES; CHALCONES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33748118759     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.022     Document Type: Article

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