N4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine - New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate)

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3520-3526

  Schott, Herbert ^a   Goltz, Daniel ^a   Schott, Timm C ^b   Jauch, Claudia ^c   Schwendener, Reto A ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

2 Deoxy 5 fluorouridine (5 FdU); Alendronate; Antimetabolite BPs; Arabinofuranosylcytosine (araC); Azidothymidine (AZT); Bone targeting

Indexed keywords

3',5' DI O ACETYL 2' DEOXY 5 FLUOROURIDINE; 5 FLUORO 4 (1,2,4 TRIAZOL 1 YL) 1 (BETA DEXTRO 3',5' DI O ACETYL 2' DEOXYRIBOFURANOSYL)PYRIDINE 2(1H) ON; 5 METHYL 4 (1,2,4 TRIAZOL 1 YL) 1 (BETA DEXTRO 5' O ACETYL 3' AZIDO 2',3' DIDEOXYRIBOFURANOSYL)PYRIDINE 2(1H) ON; ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; FLOXURIDINE; HYDROXYAPATITE; N4 [ALKYL(HYDROXYPHOSPHONO)PHOSPHATE]CYTIDINE NUCLEOSIDE; N4 [ALKYL(HYDROXYPHOSPHONO)PHOSPHONATE]CYTIDINE; N4 [BUTYL(4 HYDROXY 4 PHOSPHONO)PHOSPHONATE] 1 BETA DEXTRO ARABINO FURANOSYLCYTOSINE (URACIL ARBINOSIDE ALENDRONIC ACID); N4 [BUTYL(4 HYDROXY 4 PHOSPHONO)PHOSPHONATE] 5 FLUORO 2' DEOXYCYTIDINE (FLOXURIDINE ALENDRONIC ACID); N4 [BUTYL(4 HYDROXY 4 PHOSPHONO)PHOSPHONATE] 5 METHYL 3' AZIDO 2',3' DIDEOXYCYTIDINE (AZIDOTHYMIDINE ALENDRONIC ACID); N4 [BUTYL(4 HYDROXY 4 PHOSPHONO)PHOSPHONATE] 5 METHYL 3' AZIDO 2',3' DIDEOXYCYTIDINE (FLOXURIDINE ALENDRONIC ACID); N4 [PROPYL(3 HYDROXY 3 PHOSPHONO)PHOSPHONATE] 1 BETA DEXTRO ARABINO FURANOSYLCYTOSINE (URACIL ARABINOSIDE PAMIDRONIC ACID); N4 [PROPYL(3 HYDROXY 3 PHOSPHONO)PHOSPHONATE] 5 FLUORO 2' DEOXYCYTIDINE (FLOXURIDINE PAMIDRONIC ACID); N4 [PROPYL(3 HYDROXY 3 PHOSPHONO)PHOSPHONATE] 5 METHYL 3' AZIDO 2',3' DIDEOXYCYTIDINE (FLOXURIDINE PAMIDRONIC ACID); PAMIDRONIC ACID; UNCLASSIFIED DRUG; URACIL ARABINOSIDE; ZIDOVUDINE; 5-FLUOROURIDINE; ANTINEOPLASTIC ANTIMETABOLITE; BONE DENSITY CONSERVATION AGENT; CYTIDINE; DRUG DERIVATIVE; FLUOROURIDINE; URIDINE;

ANIMAL CELL; ARTICLE; BONE; CELL VIABILITY; CHROMATOGRAPHY; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG MIXTURE; DRUG SENSITIVITY; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INCUBATION TIME; LUNG CARCINOMA; MACROPHAGE; NONHUMAN; PURIFICATION; TUMOR CELL LINE; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; MOUSE; SYNTHESIS;

MURINAE;

ALENDRONATE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ARABINOFURANOSYLURACIL; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; CELL LINE, TUMOR; CYTIDINE; DIPHOSPHONATES; DRUG SCREENING ASSAYS, ANTITUMOR; DURAPATITE; HUMANS; MACROPHAGES; MICE; URIDINE; ZIDOVUDINE;

EID: 79957485060     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.015     Document Type: Article

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