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Preclinical in-vivo study indicating remarkable sequence-dependent synergy between chemotherapy and zoledronic acid
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Evaluation of biochemical response to bisphosphonate treatment. Demonstrated that normalisation of bone resorption was associated with improved disease outcomes
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Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates.
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Important proof of concept study showing ability to reverse biochemical 'resistance' with a novel osteoclast inhibitor
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Fizazi K, Lipton A, Mariette X, et al. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol 2009; 27:1564- 1571. Important proof of concept study showing ability to reverse biochemical 'resistance' with a novel osteoclast inhibitor.
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The causes and treatment of bone loss associated with carcinoma of the breast
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Important study defining the degree of bone loss from endocrine treatments including ovarian suppression for early breast cancer and protective effects of zoledronic acid. Also provides data on partial recovery of BMD on cessation of endocrine treatments
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Gnant M, Mlineritsch B, Luschin-Ebengreuth G, et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncol 2008; 9:840-849. Important study defining the degree of bone loss from endocrine treatments including ovarian suppression for early breast cancer and protective effects of zoledronic acid. Also provides data on partial recovery of BMD on cessation of endocrine treatments.
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N02C1: A phase III randomized, placebo-controlled, double-blind trial of risedronate for prevention of bone loss in premenopausal women undergoing adjuvant chemotherapy for breast cancer
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Provides important observation that standard osteoporosis treatment may be insufficient to prevent bone loss caused by chemotherapy induced ovarian suppression
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Hines SL, Mincey BA, Sloan JA, et al. N02C1: a phase III randomized, placebo-controlled, double-blind trial of risedronate for prevention of bone loss in premenopausal women undergoing adjuvant chemotherapy for breast cancer. J Clin Oncol 2009; 27:1047-1053. Provides important observation that standard osteoporosis treatment may be insufficient to prevent bone loss caused by chemotherapy induced ovarian suppression.
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Risedronate prevents bone loss in breast cancer survivors: A 2-year, randomized, double-blind, placebocontrolled clinical trial
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Study reporting on the efficacy of an osteoporosis schedule for the treatment of bone loss in postmenopausal breast cancer patients
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Greenspan SL, Brufsky A, Lembersky BC, et al. Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebocontrolled clinical trial. J Clin Oncol 2008; 26:2644-2652. Study reporting on the efficacy of an osteoporosis schedule for the treatment of bone loss in postmenopausal breast cancer patients.
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Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer
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First study to report the efficacy of an osteoporosis dose of ibadronate in the treatment of aromatase inhibitor induced bone loss
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Lester JE, Dodwell D, Purohit OP, et al. Prevention of anastrozole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer. Clin Cancer Res 2008; 14:6336- 6342. First study to report the efficacy of an osteoporosis dose of ibadronate in the treatment of aromatase inhibitor induced bone loss.
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31st San Antonio Breast Cancer Symposium
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6th European Breast Cancer Conference
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