Prostaglandin E2-bisphosphonate conjugates: Potential agents for treatment of osteoporosis

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 5, 1999, Pages 901-919

  Gil, Laurent ^a,c   Han, Yongxin ^a   Opas, Evan E ^b   Rodan, Gideon A ^b   Ruel, Réjean ^a   Seedor, J Gregory ^b   Tyler, Peter C ^a,d   Young, Robert N ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d CALLAGHAN INNOVATION   (New Zealand)

Author keywords

Alendronate; Bisphosphonate; Conjugate; Osteoporosis; Prostaglandin E2

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE GROWTH; CONJUGATE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; OSSIFICATION; OSTEOPENIA; OSTEOPOROSIS; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; BONE; DRUG EFFECT; TIME;

ANIMALS; BONE AND BONES; DINOPROSTONE; FEMALE; HUMANS; OSTEOPOROSIS; RATS; TIME FACTORS;

EID: 0033121313     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00045-0     Document Type: Article

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