Bisphosphonate derivatives of nucleoside antimetabolites: Hydrolytic stability and hydroxyapatite adsorption of 5′-β,γ-methylene and 5′-β,γ-(1-hydroxyethylidene) triphosphates of 5-fluorouridine and ara-cytidine

Journal of Organic Chemistry

Volumn 73, Issue 11, 2008, Pages 4123-4130

  Ora, Mikko ^a   Lönnberg, Tuomas ^a   Florea Wang, Diana ^a   Zinnen, Shawn ^b   Karpeisky, Alexander ^b   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b MBC Pharma Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; ADSORPTION; ALKALINE EARTH METALS; AMINES; CHEMICAL REACTIONS; CHEMICAL STABILITY; HYDROXYAPATITE; LIGHT METALS; METABOLISM; METAL IONS; MICROFLUIDICS; MIXTURES; TELLURIUM COMPOUNDS;

(P ,P ,T) MEASUREMENTS; ALKALINE-EARTH METAL IONS; BISPHOSPHONATE; CHEMICAL EQUATIONS; CYTIDINE; HYDROLYTIC REACTIONS; HYDROLYTIC STABILITY; MONOPHOSPHATE; ORDERS-OF-MAGNITUDE; STARTING MATERIALS; WIDE PH RANGE;

FOOD PRODUCTS;

ALKALINE EARTH METAL; ANTIMETABOLITE; BISPHOSPHONIC ACID DERIVATIVE; BUFFER; CALCIUM; CARBENE; CYTIDINE DERIVATIVE; CYTOSINE; FLUOROURIDINE; HYDROXYAPATITE; MAGNESIUM ION; METAL ION; NUCLEOSIDE DERIVATIVE; ZOLEDRONIC ACID;

ACCELERATION; AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION KINETICS; DEAMINATION; DEPHOSPHORYLATION; HUMAN; HYDROLYSIS; MOLECULAR STABILITY; MOUSE; NONHUMAN; PH; REACTION ANALYSIS;

ADSORPTION; ANIMALS; CALCIUM; CYTIDINE; DIPHOSPHONATES; HUMANS; HYDROLYSIS; KINETICS; MAGNESIUM; MICE; NUCLEOSIDES; URIDINE;

EID: 44949170797     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo800317e     Document Type: Article

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