Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2971-2983

  Čimbora Zovko, Tamara ^a   Brozovic, Anamaria ^a   Piantanida, Ivo ^a   Fritz, Gerhard ^b   Virag, Andrej ^c   Alič, Branko ^c   Majce, Vita ^c   Kočevar, Marijan ^c   Polanc, Slovenko ^c   Osmak, Maja ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

1,3 Diaryltriazenes; Apoptosis; Cytotoxicity; ROS induction; Synthesis

Indexed keywords

1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 1,3 BIS(2,4 DIFLUOROPHENYL)TRIAZENE; 1,3 BIS(2,5 DICHLOROPHENYL)TRIAZENE; 1,3 BIS(3,4 DIFLUOROPHENYL)TRIAZENE; 1,3 BIS[4 CHLORO 2 (TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 (2 FLUOROBENZOYL) 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 (2 FLUOROBENZOYL) 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 (3 FLUOROBENZOYL) 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 (4 FLUOROBENZOYL) 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 (ACETOXYACETYL) 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 [2 (TRIFLUOROMETHYL)BENZOYL] 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 [2 (TRIFLUOROMETHYL)BENZOYL] 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 [3 (2,4 DIMETHOXYPHENYL)PROP 2 ENOYL] 1,3 BIS[(2 CHLORO 5 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 [3 (3,4 DIACETOXYPHENYL)PROP 2 ENOYL] 1,3 BIS(3 FLUOROPHENYL)TRIAZENE; 3 [3 (3,4 DIACETOXYPHENYL)PROP 2 ENOYL] 1,3 BIS[4 CHLORO(3 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 [3 (3,4 DIMETHOXYPHENYL)PROP 2 ENOYL] 1,3 BIS[(2 CHLORO 5 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 [3 (3,5 DIMETHOXYPHENYL)PROP 2 ENOYL] 1,3 BIS[(2 CHLORO 5 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 [3 (4 ACETOXY 3 METHOXYPHENYL)PROP 2 ENOYL] 1,3 BIS(2 CHLORO 5 TRIFLUOROMETHYLPHENYL)TRIAZENE; 3 [3 (4 ACETOXY 3 METHOXYPHENYL)PROP 2 ENOYL] 1,3 BIS[(4 CHLORO 3 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 [3 (TRIFLUOROMETHYL)BENZOYL] 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 [3 (TRIFLUOROMETHYL)BENZOYL] 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 [4 (TRIFLUOROMETHYL)BENZOYL] 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 ACETYL 1,3 BIS(2 CHLORO 4 NITROPHENYL) 1 TRIAZENE; 3 ACETYL 1,3 BIS[(4 CHLORO 3 TRIFLUOROMETHYL)PHENYL]TRIAZENE; 3 BENZOYL 1,3 BIS(2 BROMO 4 NITROPHENYL)TRIAZENE; 3 BENZOYL 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; 3 CHLOROACETYL 1,3 BIS(2 CHLORO 4 NITROPHENYL)TRIAZENE; ANTINEOPLASTIC AGENT; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4-NITROPHENYL; CISPLATIN; DNA; NITROPHENOL; PRODRUG; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL DEATH; CONTROLLED STUDY; DNA BINDING; DRUG DNA BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LARYNX CARCINOMA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; AGONISTS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; HUMANS; NITROPHENOLS; PRODRUGS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZENES;

EID: 79957475237     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.024     Document Type: Article

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