Oxidative metabolism of 1-(2-chloroethyl)-3-alkyl-3-(methylcarbamoyl)triazenes: Formation of chloroacetaldehyde and relevance to biological activity

Chemical Research in Toxicology

Volumn 9, Issue 1, 1996, Pages 172-178

  Rouzer, Carol A ^a,b   Sabourin, Michelle ^a   Skinner, Tricia L ^a   Thompson, Erin J ^a   Wood, Thomas O ^a   Chmurny, Gwendolyn N ^c   Klose, John R ^c   Roman, John M ^c   Smith Jr , Richard H ^a,b   Michejda, Christopher J ^b  

^a WESTERN MARYLAND COLLEGE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CHLOROETHYL) 3 METHYL 3 (METHYLCARBAMOYL)TRIAZENE; 3 BENZYL 1 (2 CHLOROETHYL) 3 (METHYLCARBAMOYL)TRIAZENE; CHLOROACETALDEHYDE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; CONCENTRATION RESPONSE; LIVER MICROSOME; METABOLIC ACTIVATION; MUTAGENICITY; REACTION ANALYSIS;

ACETALDEHYDE; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOTRANSFORMATION; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZENES;

EID: 0030069798     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9500639     Document Type: Article

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