Synthesis, antitumor and antimicrobial activities of 4-(4-chlorophenyl)-3- cyano-2-(β-O-glycosyloxy)-6-(thien-2-yl)-nicotinonitrile

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2948-2954

  El Sayed, Hassan A ^a   Moustafa, Ahmed H ^a   Haikal, Abd El Fattah Z ^a   Abu El Halawa, Rajab ^b   El Ashry, El Sayed H ^c  

^a Zagazig University   (Egypt)

^b AL AL BAYT UNIVERSITY   (Jordan)

^c Alexandria University Faculty Of Science   (Egypt)

Author keywords

2 O Lactoside; 3 Cyanopyridin 2(1H) one; Antimicrobial activity; Antitumor; Microwave; Nicotinonitrile 2 O glycosides ribosides

Indexed keywords

2 ACETYL THIOPHENE; 4 (4 CHLOROPHENYL) 2 (2',3',4',6' TETRA O ACETYL BETA D GALACTOPYRANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (2',3',4',6' TETRA O ACETYL BETA D GLUCOPYRANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (2',3',5' TRI O ACETYL BETA D RIBOFURANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (2',3',5' TRI O ACETYL BETA D XYLOFURANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (BETA D GALACTOPYRANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (BETA D GLUCOPYRANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 (BETA D RIBOFURANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 2 [(2',3',4',6' TETRA O ACETYL BETA D GALACTOPYRANOSYL(1-4)](2',3',4',6' TETRA O ACETYL BETA D GLUCOPYRANOSYLOXY) 6 (THIEN 2 YL)NICOTINONITRILE; 4 (4 CHLOROPHENYL) 3 CYANO 6 (THIEN 2 YL) 1H PYRIDIN 2 ONE; 4 CHLOROBENZALDEHYDE; ACETIC ACID DERIVATIVE; AMMONIUM ACETATE; BENZALDEHYDE DERIVATIVE; DOXORUBICIN; ETHYL CYANOACETATE; FLUOROURACIL; GLYCOSIDE; NITRILE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED RADIATION; MICROANALYSIS; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; BACILLUS SUBTILIS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BACILLUS SUBTILIS; CELL LINE, TUMOR; CELL SURVIVAL; ESCHERICHIA COLI; GLYCOSIDES; HUMANS; MOLECULAR STRUCTURE; NITRILES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957467703     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.019     Document Type: Article

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