Antimicrobial activities of some synthesized pyridines, oxazines and thiazoles from 3-aryl-1-(2-naphthyl)prop-2-en-1-ones

Scientia Pharmaceutica

Volumn 76, Issue 2, 2008, Pages 279-303

  Mohamed, Salwa F ^a   Youssef, Mohamed M ^b   Amr, Abd El Galil E ^a   Kotb, Eman R ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

, unsaturated ketones; Antimicrobials; Benzoxazine; Hydrazones; Thiazoles

Indexed keywords

2 [[3 CYANO 4 (4 METHOXYPHENYL) 6 [2 NAPHTHYL]PYRIDIN 2 YL]OXY] N [4 OXO 2 (PHENYLIMINO) 1,3 THIAZOLIDIN 3 YL]ACETAMIDE; 2 [[3 CYANO 4 (4 METHOXYPHENYL) 6 [2 NAPHTHYL]PYRIDIN 2 YL]OXY]ACETOHYDRAZIDE; 2 [[3 CYANO 4 (4 METHOXYPHENYL) 6 [2-NAPHTHYL]PYRIDIN 2 YL]OXY] N (4 OXO 2 PHENYL 1,3 THIAZOLIDIN 3 YL)ACETAMIDE; 2 [[3 CYANO 6 (2 NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY] N (4 OXO 2 PHENYL 1,3 THIAZOLIDIN 3 YL)ACETAMIDE; 2 [[3 CYANO 6 (2 NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY] N [4 OXO 2 (PHENYLIMINO) 1,3 THIAZOLIDIN 3 YL]ACETAMIDE; 2 [[3 CYANO 6 (2-NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY]ACETOHYDRAZIDE; 2 [[[3 CYANO 4 (4 METHOXYPHENYL) 6 [2 NAPHTHYL]PYRIDIN 2 YL]OXY]ACETYL] N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 [[[3 CYANO 6 (2 NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY]ACETYL] N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 AMINO 4 (4 METHOXYPHENYL) 6 (2 NAPHTHYL) 4H PYRAN 3 CARBONITRILE; 2 AMINO 4 (4 METHOXYPHENYL) 6 (2 NAPHTHYL)NICOTINONITRILE; 2 AMINO 6 (2 NAPHTHYL) 4 PHENYL 4H PYRAN 3 CARBONITRILE; 2 AMINO 6 (2 NAPHTHYL) 4 PHENYLNICOTINONITRILE; 3 ARYL 1 (2 NAPHTHYL) PROP 2 EN 1 ONE DERIVATIVE; 4 (4 METHOXYPHENYL) 6 (2 NAPHTHYL) 2 [(4 OXO 4H 3,1 BENZOXAZIN 2 YL)METHOXY]NICOTINONITRILE; 4 (4 METHOXYPHENYL) 6 (2 NAPHTHYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6 (2 NAPHTHYL) 2 [(4 OXO 4H 3,1 BENZOXAZIN 2 YL)METHOXY] 4 PHENYLNICOTINONITRILE; 6 (2 NAPHTHYL) 2 OXO 4 PHENYL 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; [1 (4 METHOXYPHENYL) 3 [2 NAPHTHYL)]3 OXOPROPYL]MALONONITRILE; [3 (2 NAPHTHYL) 3 OXO 1 PHENYLPROPYL]MALONONITRILE; AMPICILLIN; ANTIINFECTIVE AGENT; CHLORAMPHENICOL; ETHYL [[3 CYANO 4 (4 METHOXYPHENYL) 6 [2 NAPHTHYL]PYRIDIN 2 YL]OXY]ACETATE; ETHYL [[3 CYANO 6 (2 NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY]ACETATE; N' BENZYLIDENE 2 [[3 CYANO 4 (4 METHOXYPHENYL) 6 [2 NAPHTHYL]PYRIDIN 2 YL]OXY]ACETOHYDRAZIDE; N' BENZYLIDENE 2 [[3 CYANO 6 (2 NAPHTHYL) 4 PHENYLPYRIDIN 2 YL]OXY]ACETOHYDRAZIDE; OXAZINE DERIVATIVE; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNINDEXED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANDIDA ALBICANS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG RESEARCH; DRUG SYNTHESIS; ESCHERICHIA COLI; LACTOCOCCUS LACTIS; NONHUMAN; PENICILLIUM; PSEUDOMONAS PUTIDA; STRUCTURE ACTIVITY RELATION;

EID: 46249133609     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.0804-09     Document Type: Article

References (17)

1. Abdel-Latif NA. Synthesis and antidepressant activity of some new coumarin derivatives. Sci Pharm. 2005; 74: 193-216.
2. Amr AE, Abdel-Latif NA, Abdalla MM. Synthesis of some new testosterone derivatives fused with substituted pyrazoline ring as 5α-reductase inhibitors. Acta Pharm. 2006; 56: 203-218.
3. Amr AE, Abdel-Latif NA, Abdalla MM. Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16-c]-5′-aryl-pyrazoline and their derivatives. Bioorg Med Chem. 2006; 14: 373-384. [doi:10.1016/j.bmc.2005. 08.024]
4. Amr AE. Synthesis of some new linear and chiral macrocyclic pyridine carbazides as analgesic and anticonvulsant agents. Z Naturforsch. 2005; 60b: 990-998.
5. Amr AE, Sayed HH, Abdulla MM. Synthesis and reactions of some new substituted pyridine and pyrimidine derivatives as analgesic, anticonvulsant and antiparkinsonian agents. Arch Pharm Chem Life Sci. 2005; 338: 433-440. [doi:10.1002/ardp.200500982]
6. Abo-Ghalia MH, Amr AE. Synthesis and investigation of a new cyclo-(Nα-dipicolinoyl)pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specifity. Amino Acids. 2004; 26: 283-289. [doi:10.1007/s00726-003-0042-8]
7. Hammam AG, Fahmy AF, Amr AE, Mohamed AM. Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons. Ind J Chem. 2003; 42B: 1985-1993.
8. Lakhvich FA, Koroleva EV, Akhrem AA. Synthesis, chemical transformation, and application of isoxazole derivatives in the total chemical synthesis of natural compounds. Chem Heterocycl Comp. 1989; 25: 359-375. [doi:10.1007/ BF00480746]
9. Mukhtar S, Ramadan M, Ansari W, Lemiere G, De Groot A, Dommisse R. Bifunctional derivative of p,p′-dichlorochalcone Part II. Synthesis of a novel compound 2-[2-carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4- chlorophenyl)-4-thiazolidinone. Molecules. 1999; 4: 232-237.
10. Bae SH, Kim KS, Park Y. Reactions of Tetrasulfur Tetranitride Antimony Pentachloride Complex (S4N4•SbCl5) with Primary β-Enaminones and β-Enamino Esters: Synthesis of 4-Substituted 3-Aroyl- and 3-Ethoxycarbonyl-1,2,5-thiadiazoles. Heterocycles. 2000; 53: 159-172.
11. Swellem RH, Allam YA, Nawwar GA. Synthesis of 3-Phenylisoxazolo[3,4-a] carbazoles. Z Naturforsch. 1999; 54b: 1197-2201.
12. Bakhite EA. Convenient heterocyclization reactions with 2-functionalized 3-amino-4-aryl-5,6,7,8-tetrahydrothieno[2,3-b]quinolines: Synthesis of new thienoquinolines, pyridothienoquinolines, pyranothienoquinolines and pyrimidothienoquinolines. J Chem Res Synop. 2000; 11: 500-501.
13. Al-Shikh MA, El-Din AMS, Hafez EA, Elnagdi MH. á-Enones in heterocyclic synthesis, part I. Classical synthetic and environmentally friendly synthetic approaches to alkyl and acyl azoles and azines. J Chem Res. 2004; 174-179.
14. Lim SS, Jung SH, Ji J, Shin KH, Keum SR. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol. 2001; 53: 653-668. [doi:10.1211/0022357011775983]
15. Nehad AA, Amr EA, Alhusien AI. Synthesis, reactions and pharmacological screening of heterocyclic derivatives Using nicotinic acid as a natural synthon. Monatsh Chem. 2007; 138: 559-567. [doi:10.1007/s00706-007-0628-z]
16. Attia A, Abdel-Salam OI, Abo-Ghalia MH, Amr EA. Chemical and biological reactivity of newly synthesized 2-chloro-6-ethoxy-4-acetylpyridine. Egypt J Chem. 1995; 38: 543-553.
17. Coffen DL, Korzan DG. Synthetic quinine analogs. III. Frangomeric and anchimeric processes in the preparation and reactions of α,β-epoxy ketones. J Org Chem. 1971; 36: 390-395. [doi:10.1021/jo00802a006]