Synthesis and antibacterial activity of novel 4″-O-benzimidazolyl clarithromycin derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3105-3111

  Cong, Chao ^a   Wang, Haiyang ^b   Hu, Yue ^c   Liu, Chen ^a   Ma, Siti ^a   Li, Xin ^a   Cao, Jichao ^a   Ma, Shutao ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Antibacterial activity; Benzimidazolyl derivatives; Clarithromycin; Synthesis

Indexed keywords

1H BENZIMIDAZOLE 5 CARBOHYDRAZIDE; 2 (4 CHLOROPHENYL) 1H BENZIMIDAZOLE 5 CARBOXYLIC ACID; 2 (4 METHOXYPHENYL) 1H BENZIMIDAZOLE 5 CARBOXYLIC ACID; 2 (4 TRIFLUORMETHYL) 1H BENZIMIDAZOLE 5 CARBOXYLIC ACID; 2 PHENYL 1H BENZIMIDAZOLE 5 CARBOHYDRAZIDE; 2 TRIFLUORMETHYL 1H BENZIMIDAZOLE 5 CARBOHYDRAZIDE; 4'' O (1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (2 CHLOROPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (2 HYDROXYL 5 CHLOROPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (2 METHOXYPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (3 METHOXYPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (3 NITROPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 BROMOPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 CHLOROPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 METHOXYPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 METHYLPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 NITROPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 (4 TRIFLUORMETHYLPHENYL) 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 ETHYL 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 ISOPROPYL 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 METHYL 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 PHENYL 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O (2 PROPYL 1H BENZIMIDAZOLE 5 CARBONYL) HYDRAZINECARBONYLCLARITHROMYCIN; 4'' O BENZIMIDAZOLYL CLARITHROMYCIN DERIVATIVE; AZITHROMYCIN; CARBOXYLIC ACID DERIVATIVE; CLARITHROMYCIN; CLARITHROMYCIN DERIVATIVE; HYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BENZIMIDAZOLE DERIVATIVE; ERMA PROTEIN, BACTERIA; ERYTHROMYCIN; HYDRAZINE DERIVATIVE; MEFA PROTEIN, STREPTOCOCCUS; MEMBRANE PROTEIN; METHYLTRANSFERASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; ANALOGS AND DERIVATIVES; ANTIBIOTIC RESISTANCE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BENZIMIDAZOLES; CLARITHROMYCIN; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; GENE EXPRESSION; HYDRAZINES; MEMBRANE PROTEINS; METHYLTRANSFERASES; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957449856     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.004     Document Type: Article

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