Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 19, 2011, Pages 7956-7961

  Orlovsky, Kira ^a   Kalinkovich, Alexander ^a   Rozovskaia, Tanya ^a   Shezen, Elias ^a   Itkin, Tomer ^a   Alder, Hansjuerg ^b   Ozer, Hatice Gulcin ^c   Carramusa, Letizia ^a   Avigdor, Abraham ^d   Volinia, Stefano ^b   Buchberg, Arthur ^e   Mazo, Alex ^e   Kollet, Orit ^a   Largman, Corey ^f   Croce, Carlo M ^b   Nakamura, Tatsuya ^b   Lapidot, Tsvee ^a   Canaani, Eli ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d SHEBA MEDICAL CENTER   (Israel)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bone marrow colonization of leukemic cells; Leukemic cells' migration

Indexed keywords

BROXURIDINE; HOMEODOMAIN PROTEIN; MEIS1 HOMEOBOX PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR HOXA7; TRANSCRIPTION FACTOR HOXA9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE INACTIVATION; GENE REARRANGEMENT; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; GENE REARRANGEMENT; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 79956367111     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1103154108     Document Type: Article

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