Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

European Journal of Haematology

Volumn 83, Issue 5, 2009, Pages 406-419

  Trentin, Luca ^a   Giordan, Marco ^a   Dingermann, Theo ^b   Basso, Giuseppe ^a   Te Kronnie, Geertruy ^a   Marschalek, Rolf ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Acute leukemia; AF4 gene; Gene expression profiles; MLL gene; T(4; 11)

Indexed keywords

BIOLOGICAL MARKER; CD135 ANTIGEN; CD72 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; DNA; FAS ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN 4; MIXED LINEAGE LEUKEMIA PROTEIN; MYOCYTE ENHANCER FACTOR 2; RNA; SOMATOMEDIN BINDING PROTEIN 3; SUPPRESSOR OF CYTOKINE SIGNALING 2; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR SOX4;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW BIOPSY; CANCER CLASSIFICATION; CHILD; CHILDHOOD CANCER; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DNA SEQUENCE; FEMALE; FUSION GENE; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE OVEREXPRESSION; GENE SIGNATURE; GENE TRANSLOCATION; GROUPS BY AGE; HOXA 10 GENE; HOXA 5 GENE; HOXA 9 GENE; HUMAN; HUMAN CELL; INFANT; INTRON; MALE; MICROARRAY ANALYSIS; MLL GENE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; TRANSCRIPTION REGULATION;

CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; HOMEODOMAIN PROTEINS; HUMANS; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSLOCATION, GENETIC;

EID: 70349964642     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01305.x     Document Type: Article

References (47)

1. Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002 30 : 41 7.
2. Yeoh EJ, Ross ME, Shurtleff SA, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002 1 : 133 143.
3. Ferrando AA, Armstrong SA, Neuberg DS, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003 102 : 262 268.
4. Ross ME, Zhou X, Song G, et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003 102 : 2951 2959. (Pubitemid 37248870)
5. Rozovskaia T, Ravid-Amir O, Tillib S, et al. Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements. Proc Natl Acad Sci USA 2003 100 : 7853 7858.
6. Haferlach T, Kohlmann A, Schnittger S, et al. Global approach to the diagnosis of leukemia using gene expression profiling. Blood 2005 106 : 1189 1198.
7. Kohlmann A, Schoch C, Dugas M, et al. New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes. Leukemia 2005 19 : 953 964.
8. Holleman A, Cheok MH, den Boer ML, et al. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med 2004 351 : 533 542.
9. Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 2003 17 : 2298 2307.
10. Meyer C, Kowarz E, Hofmann J, et al. New insights into the MLL recombinome of acute leukemias. Leukemia 2009 March 5. [Epub ahead of print].
11. Haferlach T, Kohlmann A, Basso G, et al. The clinical utility of microarray-based gene expression profiling in the diagnosis and sub-classification of leukemia: Final Report on 3252 Cases from the International MILE Study Group. Blood (ASH Annual Meeting Abstracts). 2008 112 : Abstract 753.
12. Hess JL. Mechanisms of transformation by MLL. Crit Rev Eukaryot Gene Expr 2004 14 : 235 254.
13. Horton SJ, Grier DG, McGonigle GJ, et al. Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells. Cancer Res 2005 65 : 9245 9252.
14. Milne TA, Hughes CM, Lloyd R, et al. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci USA 2005 102 : 749 754.
15. Milne TA, Dou Y, Martin ME, Brock HW, Roeder RG, Hess JL. MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci USA 2005 102 : 14765 14770.
16. Milne TA, Martin ME, Brock HW, Slany RK, Hess JL. Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. Cancer Res 2005 65 : 11367 11374.
17. Reichel M, Gillert E, Angermüller S, et al. Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL. Oncogene 2001 20 : 2900 2907.
18. Bursen A, Moritz S, Gaussmann A, Moritz S, Dingermann T, Marschalek R. Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? Oncogene 2004 23 : 6237 6249.
19. Gaussmann A, Wenger T, Eberle I, et al. The combined effects of the two reciprocal t(4;11) fusion proteins, MLL·AF4 and AF4·MLL, confer resistance to apoptosis, cell cycling capacity and growth transformation. Oncogene 2006 26 : 3352 6333.
20. Kowarz E, Burmeister T, Lo Nigro L, et al. Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele. Leukemia 2007 21 : 1232 1238.
21. Hanson RD, Hess JL, Yu BD, et al. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci USA 1999 96 : 14372 14377.
22. Shimo T, Kubota S, Yoshioka N, et al. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res 2006 21 : 1045 1059.
23. Sala-Torra O, Gundacker HM, Stirewalt DL, et al. Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia. Blood 2007 109 : 3080 3083.
24. Schwarting R, Castello R, Moldenhauer G, et al. Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias. Am J Hematol 1992 41 : 151 158.
25. Tretter T, Ross AE, Dordai DI, Desiderio S. Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. J Exp Med 2003 198 : 1863 1873.
26. Liao B, Hu Y, Herrick DJ, Brewer G. The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells. J Biol Chem 2005 280 : 18517 18524.
27. Bash-Babula J, Toppmeyer D, Labassi M, et al. A Phase I/pilot study of sequential doxorubicin/vinorelbine: effects on p53 and microtubule-associated protein 4. Clin Cancer Res 2002 8 : 1057 1064.
28. Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007 128 : 325 339.
29. Schneider TJ, Fischer GM, Donohoe TJ, Colarusso TP, Rothstein TL. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J Exp Med 1999 189 : 949 956.
30. Liu P, Ramachandran S, Ali Seyed M, et al. Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res 2006 66 : 4011 4019.
31. Kuiper RP, Schepens M, Thijssen J, et al. Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. Hum Mol Genet 2003 12 : 1661 1669.
32. Fisher DE, Carr CS, Parent LA, Sharp PA. TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family. Genes Dev 1991 5 : 2342 2352.
33. Swanson BJ, Jäck HM, Lyons GE. Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes. Mol Immunol 1998 35 : 445 458.
34. Du Y, Spence SE, Jenkins NA, Copeland NG. Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood 2005 106 : 2498 2505.
35. Baldus CD, Tanner SM, Ruppert AS, et al. BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a cancer and leukemia group B study. Blood 2003 102 : 1613 1618.
36. Baldus CD, Tanner SM, Kusewitt DF, et al. BAALC, a novel marker of human hematopoietic progenitor cells. Exp Hematol 2003 31 : 1051 1056.
37. Gibbons RJ, Pellagatti A, Garrick D, et al. Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS). Nat Genet 2003 34 : 446 449.
38. Robertson KA, Hill DP, Kelley MR, et al. The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells. Leukemia 1998 12 : 690 698.
39. Lee TI, Jenner RG, Boyer LA, et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 2006 125 : 301 313.
40. Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998 17 : 3714 3725.
41. Zeisig BB, Milne T, Garcia-Cuellar MP, et al. Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 2004 24 : 617 628.
42. Wang GG, Pasillas MP, Kamps MP. Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Mol Cell Biol 2006 26 : 3902 3916.
43. Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 2003 3 : 173 183.
44. Stam RW, den Boer ML, Schneider P, et al. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood 2005 106 : 2484 2490.
45. Bertrand FE, Spengeman JD, Shah N, LeBien TW. B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. Leukemia 2003 17 : 2454 2459.
46. Chen J, Santillan DA, Koonce M, et al. Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer Res 2008 68 : 6199 6207.
47. Muntean AG, Giannola D, Udager AM, Hess JL. The PHD fingers of MLL block MLL fusion protein-mediated transformation. Blood 2008 112 : 4690 4693.