Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender

European Journal of Human Genetics

Volumn 19, Issue 6, 2011, Pages 672-675

  Ryoo, Hyunju ^a   Woo, Jiyoung ^a   Kim, Younyoung ^a   Lee, Chaeyoung ^a  

^a Soongsil University   (South Korea)

Author keywords

genetic association; genetic polymorphisms; genetic risk factors

Indexed keywords

CYCLIN DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASE 5 REGULATORY SUBUNIT ASSOCIATED PROTEIN 1 LIKE 1; HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN; HOMEODOMAIN PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HOMEOBOX; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH KOREA;

ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; COHORT STUDIES; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; REPUBLIC OF KOREA; SEX FACTORS; TRANSCRIPTION FACTORS;

EID: 79956317360     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2011.6     Document Type: Article

References (25)

1. Saxena R, Voight BF, Lyssenko V et al: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316: 1331-1336. (Pubitemid 46871653)
2. Scott LJ, Mohlke KL, Bonnycastle LL et al: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345. (Pubitemid 46871655)
3. Sladek R, Rocheleau G, Rung J et al: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445: 881-885.
4. Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007; 39: 770-775. (Pubitemid 46848592)
5. Zeggini E, Weedon MN, Lindgren CM et al: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336-1341. (Pubitemid 46871654)
6. Dehwah MA, Wang M, Huang QY: CDKAL1 and type 2 diabetes: a global meta-analysis. Genet Mol Res 2010; 9: 1109-1120.
7. Franconi F, Seghieri G, Canu S, Straface E, Campesi I, Malorni W: Are the available experimental models of type 2 diabetes appropriate for a gender perspective? Pharmacol Res 2008; 57: 6-18.
8. Cho Y, Go M, Kim Y et al: A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 2009; 41: 527-534.
9. Lee YH, Kang ES, Kim SH et al: Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J Hum Genet 2008; 53: 991-998.
10. Omori S, Tanaka Y, Takahashi A et al: Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008; 57: 791-795.
11. Wu Y, Li H, Loos RJ et al: Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 2008; 57: 2834-2843.
12. Han X, Luo Y, Ren Q et al: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 2010; 11: 81.
13. Wen J, Rönn T, Olsson A et al: Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One 2010; 5: e9153.
14. Horikawa Y, Miyake K, Yasuda K et al: Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 2008; 93: 3136-3141.
15. Lew J, Huang QQ, Qi Z et al: A brain-specific activator of cyclin-dependent kinase 5. Nature 1994; 371: 423-426. (Pubitemid 24302557)
16. Ubeda M, Rukstalis JM, Habener JF: Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J Biol Chem 2006; 281: 28858-28864. (Pubitemid 44507029)
17. Takeuchi F, Serizawa M, Yamamoto K et al: Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 2009; 58: 1690-1699.
18. Pascoe L, Tura A, Patel SK et al: Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007; 56: 3101-3104. (Pubitemid 350223648)
19. Staiger H, Stancáková A, Zilinskaite J et al: A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 2008; 57: 514-517.
20. Buffington CK, Givens JR, Kitabchi AE: Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females. Diabetes 1991; 40: 693-700.
21. Jones ME, Thorburn AW, Britt KL et al: Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 2000; 97: 12735-12740.
22. Margolis KL, Bonds DE, Rodabough RJ et al: Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia 2004; 47: 1175-1187. (Pubitemid 39093314)
23. Altucci L, Addeo R, Cicatiello L et al: Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. Endocrinology 1997; 138: 978-984. (Pubitemid 27089749)
24. Arafah BM: Increased need for thyroxine in women with hypothyroidismduring estrogen therapy. N Engl J Med 2001; 344: 1743-1749. (Pubitemid 32497028)
25. Pellizzari L, D¢Elia A, Rustighi A, Manfioletti G, Tell G, Damante G: Expression and function of the homeodomain-containing protein Hex in thyroid cells. Nucleic Acids Res 2000; 28: 2503-2511. (Pubitemid 30420847)