Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: Candidate intermediates in formation and export of mRNA

Molecular and Cellular Biology

Volumn 21, Issue 21, 2001, Pages 7307-7319

  Mili, S ^a   Hong Jun Shu, ^a   Zhao, Y ^a   Pinol Roma S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RIBONUCLEOPROTEIN;

ARTICLE; HELA CELL; HUMAN; HUMAN CELL; MESSENGER RNA SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; RNA PROCESSING; RNA SPLICING; RNA TRANSPORT;

ANIMALS; CELL NUCLEUS; CYTOPLASM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; IMMUNOBLOTTING; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; RNA; RNA, MESSENGER; SUBCELLULAR FRACTIONS; ULTRAVIOLET RAYS;

EID: 0034791334     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.21.7307-7319.2001     Document Type: Article

References (77)

1. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF/hnRNP D
4. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
5. Mass spectrometry of peptides and proteins
6. Cytoskeleton involvement in the distribution of mRNP complexes and small cytoplasmic RNAs
7. A role for transcription and FRGY2 in masking maternal mRNA within Xenopus oocytes
8. Conserved structures and diversity of functions of RNA-binding proteins
9. Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: A diversity of RNA-binding proteins is generated by small peptide inserts
10. A specific subset of SR proteins shuttles between the nucleus and the cytoplasm
11. Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells
12. Regulation of HIV depends upon recognition of splice sites
13. Isolation of the heterogeneous nuclear ribonucleoprotein complex (hnRNP): A unique supramolecular assembly
14. Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells
15. A look at messenger RNP moving through the nuclear pore
16. Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies
17. HnRNP proteins and the biogenesis of mRNA
18. Internet-based analytical chemistry resource: A model project
19. The mRNA poly(A)-binding protein: Localization, abundance, and RNA-binding specificity
20. Two-dimensional electrophoresis reveals a nuclear matrix-associated nucleolin complex of basic isoelectric point
21. Splicing as a requirement for biogenesis of functional 16S mRNA of simian virus 40
22. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
23. Splicing and the formation of stable RNA
24. Molecular cloning and expression of the gene for a major leucine-rich protein from human hepatoblastoma cells (HEPG2)
25. The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs
26. n
27. Transport of macromolecules between the nucleus and the cytoplasm
28. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export
29. Active disruption of an RNA-protein interaction by a DExH/D RNA helicase
30. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
31. Pre-mRNA splicing imprints mRNA in the nucleus with a novel. RNA-binding protein that persists in the cytoplasm
32. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm
33. hnRNP complexes: Composition, structure and function
34. Squid hnRNP protein promotes apical cytoplasmic transport and localization of Drosophila pair-rule transcripts
35. 14C in polyacrylamide gels by fluorography
36. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
37. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
38. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
39. HnRNP L binds a cis-acting RNA sequence element that enables intron-independent gene expression
40. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
41. Splicing is required for rapid and efficient mRNA export in metazoans
42. BSF binds specifically to the bicoid mRNA 3′ untranslated region and contributes to stabilization of bicoid mRNA
43. Association of individual hnRNP proteins and snRNPs with nascent transcripts
44. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein
45. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
46. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
47. The K nuclear shuttling domain: A novel signal for nuclear import and nuclear export in the hnRNP K protein
48. The balance between two isoforms of the Drosophila RNA-binding protein. How controls tendon differentiation
49. Molecular structure of the human cytoplasmic beta-actin gene: Interspecies homology of sequences in the introns
50. The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
51. Transport of proteins and RNAs in and out of the nucleus
52. Specific isoforms of Squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis
53. High resolution two-dimensional gel electrophoresis of basic as well as acidic proteins
54. Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis
55. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway
56. Proteins associated with heterogeneous nuclear RNA in eukaryotic cells
57. HnRNP proteins and the nuclear export of mRNA
58. Ultraviolet-induced crosslinking of RNA to proteins in vivo
59. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals and assortment of RNA-binding proteins
60. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
61. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts
62. A novel receptor-mediated nuclear protein import pathway
63. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
64. De novo peptide sequencing in an ion trap mass spectrometer with 18O labeling
65. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
66. 1130)
67. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
68. The PPR motif - A TPR-related motif prevalent in plant organellar proteins
69. RNA transport from nucleus to cytoplasm in Chironomus salivary glands
70. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
71. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
72. Specificity in the interaction of hnRNP and mRNA with proteins as revealed by in vivo cross linking
73. A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
74. Structure and genomic organization of the human AUF1 gene: Alternative pre-mRNA splicing generates four protein isoforms
75. + RNA export
76. Identification of two RNA-binding proteins in Balbiani ring premessenger ribonucleoprotein granules and presence of these proteins in specific subsets of heterogeneous nuclear ribonucleoprotein particles
77. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans