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Various mechanistic possibilities exist for C - H activation with Pd(II). These most frequently link electrophilic aromatic substitution to electron-rich, π-excessive (hetero)arenes and, more recently, concerted metalation - deprotonation for simple and electron-deficient arenes. For a summary of mechanistic possibilities and leading references, see: Gorelsky, S. I.; Lapomte, D.; Fagnou, K. J. Am. Chem. Soc. 2008, 130, 10848.
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Various mechanistic possibilities exist for C - H activation with Pd(II). These most frequently link electrophilic aromatic substitution to electron-rich, π-excessive (hetero)arenes and, more recently, concerted metalation - deprotonation for simple and electron-deficient arenes. For a summary of mechanistic possibilities and leading references, see: Gorelsky, S. I.; Lapomte, D.; Fagnou, K. J. Am. Chem. Soc. 2008, 130, 10848.
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(7) and C(9) regioisomers and C(7)/C(9) bishalogenation products: Cheng, D
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The possibility that the C=O group directs palladation at C(7) has been rasied by a reviewer, and carbonyl directing effects have been recently reported: Giri, R.; Yu, J.-Q J. Am. Chem. Soc. 2008, 130, 14082.
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The possibility that the C=O group directs palladation at C(7) has been rasied by a reviewer, and carbonyl directing effects have been recently reported: Giri, R.; Yu, J.-Q J. Am. Chem. Soc. 2008, 130, 14082.
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