1α,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 3, 2011, Pages 846-859

  Chow, Edwin C Y ^a   Durk, Matthew R ^a   Cummins, Carolyn L ^a   Pang, K Sandy ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; DIGOXIN; FARNESOID X RECEPTOR; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; TRITIUM; VITAMIN D RECEPTOR; BILE ACID; CALCITRIOL RECEPTOR; CARDIOTONIC AGENT; CELL RECEPTOR; COTRANSPORTER; DIHYDROXY VITAMIN D3; DIHYDROXY-VITAMIN D3; DRUG DERIVATIVE; FARNESOID X-ACTIVATED RECEPTOR; ORGANIC ANION TRANSPORTER; SODIUM BILE ACID COTRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; VITAMIN; VITAMIN D;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MUSCLE LEVEL; DRUG TRANSPORT; FEMALE; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; LIVER LEVEL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; TREATMENT DURATION; ANIMAL; BRAIN; DRUG EFFECT; KIDNEY; LIVER; METABOLISM; MOUSE MUTANT; UPREGULATION;

ANIMALS; AREA UNDER CURVE; BILE ACIDS AND SALTS; BRAIN; CARDIOTONIC AGENTS; DIGOXIN; FEMALE; KIDNEY; LIVER; MALE; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; P-GLYCOPROTEIN; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SYMPORTERS; UP-REGULATION; VITAMIN D; VITAMINS;

EID: 79956223783     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.179101     Document Type: Article

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