Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 6, 1997, Pages 673-694

  Van Schaick, Erno A ^a   De Greef, Henrik J M M ^a   Ijzerman, Adriaan P ^a   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Adenosine A1 receptor; Conscious rats; Glycerol; Indirect response; N6 (p sulfophenyl)adenosine; NEFA; Pharmacokinetic pharmacodynamic modeling; Validation

Indexed keywords

ADENOSINE A1 RECEPTOR AGONIST; FATTY ACID; GLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CROSSOVER PROCEDURE; DRUG ELIMINATION; FATTY ACID METABOLISM; GLYCEROL BLOOD LEVEL; HYPOTHESIS; LIPOLYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ADENOSINE; ANIMALS; ANTILIPEMIC AGENTS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, NONESTERIFIED; GLYCEROL; INFUSIONS, INTRAVENOUS; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1;

EID: 0031403631     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025777700413     Document Type: Article

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