-
1
-
-
0025910992
-
Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: Long-term follow-up of an Eastern Cooperative Oncology Group randomized trial
-
Raphael B., Andersen J.W., Silber R., Oken M., Moore D., Bennett J., et al. Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia Long-term follow-up of an Eastern Cooperative Oncology Group randomized trial. J Clin Oncol. 9:1991;770-776
-
(1991)
J Clin Oncol
, vol.9
, pp. 770-776
-
-
Raphael, B.1
Andersen, J.W.2
Silber, R.3
Oken, M.4
Moore, D.5
Bennett, J.6
-
2
-
-
0028945716
-
2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia
-
Saven A., Lemon R.H., Kosty M., Beutler E., Piro L.D. 2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia. J Clin Oncol. 13:1995;570-574
-
(1995)
J Clin Oncol
, vol.13
, pp. 570-574
-
-
Saven, A.1
Lemon, R.H.2
Kosty, M.3
Beutler, E.4
Piro, L.D.5
-
3
-
-
0028913580
-
Cladribine in the treatment of relapsed or refractory chronic lymphocytic leukemia
-
Tallman M.S., Hakimian D., Zanzig C., Hogan D.K., Rademaker A., Rose E., et al. Cladribine in the treatment of relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol. 13:1995;983-988
-
(1995)
J Clin Oncol
, vol.13
, pp. 983-988
-
-
Tallman, M.S.1
Hakimian, D.2
Zanzig, C.3
Hogan, D.K.4
Rademaker, A.5
Rose, E.6
-
4
-
-
0024551346
-
Pentostatin in chronic lymphocytic leukemia: A phase II trial of Cancer and Leukemia Group B
-
Dillman R.O., Mick R., McIntyre O.R. Pentostatin in chronic lymphocytic leukemia A phase II trial of Cancer and Leukemia Group B. J Clin Oncol. 7:1989;433-438
-
(1989)
J Clin Oncol
, vol.7
, pp. 433-438
-
-
Dillman, R.O.1
Mick, R.2
McIntyre, O.R.3
-
5
-
-
0024319910
-
Fludarabine: A new agent with major activity against chronic lymphocytic leukemia
-
Keating M.J., Kantarjian H., Talpaz M., Redman J., Koller C., Barlogie B., et al. Fludarabine A new agent with major activity against chronic lymphocytic leukemia. Blood. 74:1989;19-25
-
(1989)
Blood
, vol.74
, pp. 19-25
-
-
Keating, M.J.1
Kantarjian, H.2
Talpaz, M.3
Redman, J.4
Koller, C.5
Barlogie, B.6
-
6
-
-
0001627455
-
Clinical evaluation of CB 1348 in malignant lymphoma and related diseases
-
Israels L.G., Galton D.A.G., Till M., Wiltshaw E. Clinical evaluation of CB 1348 in malignant lymphoma and related diseases. Ann NY Acad Sci. 68:1958;915-925
-
(1958)
Ann NY Acad Sci
, vol.68
, pp. 915-925
-
-
Israels, L.G.1
Galton, D.A.G.2
Till, M.3
Wiltshaw, E.4
-
8
-
-
0026330995
-
Treatment of chronic lymphocytic leukemia: A preliminary report of Spanish (PETHEMA) trials
-
Montserrat E., Fontanilles M., Estape J. Treatment of chronic lymphocytic leukemia A preliminary report of Spanish (PETHEMA) trials. Leuk Lymphoma. 5:(suppl):1991;89-91
-
(1991)
Leuk Lymphoma
, vol.5
, Issue.SUPPL.
, pp. 89-91
-
-
Montserrat, E.1
Fontanilles, M.2
Estape, J.3
-
9
-
-
0017730147
-
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia
-
Sawitsky A., Rai K.R., Glidewell O., Silver R.T. Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia. Blood. 50:1977;1049-1059
-
(1977)
Blood
, vol.50
, pp. 1049-1059
-
-
Sawitsky, A.1
Rai, K.R.2
Glidewell, O.3
Silver, R.T.4
-
10
-
-
0003108715
-
High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia: Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna
-
Jaksic B., Brugiatelli M., Krc I., Losonczi H., Hoowiecki J., Planinc-Peraica A., et al. High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna. Cancer. 79:1997;2107-2114
-
(1997)
Cancer
, vol.79
, pp. 2107-2114
-
-
Jaksic, B.1
Brugiatelli, M.2
Krc, I.3
Losonczi, H.4
Hoowiecki, J.5
Planinc-Peraica, A.6
-
11
-
-
0024212762
-
High dose continuous chlorambucil vs intermittent chlorambucil plus prednisone for treatment of B-CLL IGCI CLL-01 trial
-
Jaksic B., Brugiatelli M. High dose continuous chlorambucil vs intermittent chlorambucil plus prednisone for treatment of B-CLL IGCI CLL-01 trial. Nouv Rev Fr Hematol. 30:1988;437-442
-
(1988)
Nouv Rev Fr Hematol
, vol.30
, pp. 437-442
-
-
Jaksic, B.1
Brugiatelli, M.2
-
12
-
-
0015596378
-
Chlorambucil vs combined chlorambucil-corticosteroid therapy in chronic lymphocytic leukemia
-
Han T., Ezdinli E.Z., Shimaoka K., Desai D.V. Chlorambucil vs combined chlorambucil-corticosteroid therapy in chronic lymphocytic leukemia. Cancer. 31:1973;502-508
-
(1973)
Cancer
, vol.31
, pp. 502-508
-
-
Han, T.1
Ezdinli, E.Z.2
Shimaoka, K.3
Desai, D.V.4
-
13
-
-
0027201037
-
Chronic lymphocytic leukaemia treatment
-
Montserrat E., Rozman C. Chronic lymphocytic leukaemia treatment. Blood Rev. 7:1993;164-175
-
(1993)
Blood Rev
, vol.7
, pp. 164-175
-
-
Montserrat, E.1
Rozman, C.2
-
14
-
-
0024246409
-
CHOP versus prednisone + chlorambucil in chronic lymphocytic leukemia: Preliminary results of a randomized multicenter study
-
Hansen M.M., Andersen E., Birgeus H., Christensen B.E., Christensen T.G., Gisler C. CHOP versus prednisone + chlorambucil in chronic lymphocytic leukemia Preliminary results of a randomized multicenter study. Nouv Rev Fr Hematol. 30:1998;433-436
-
(1998)
Nouv Rev Fr Hematol
, vol.30
, pp. 433-436
-
-
Hansen, M.M.1
Andersen, E.2
Birgeus, H.3
Christensen, B.E.4
Christensen, T.G.5
Gisler, C.6
-
15
-
-
0033583824
-
Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials
-
CLL Trialists Collaborative Group. Chemotherapeutic options in chronic lymphocytic leukemia A meta-analysis of the randomized trials. J Natl Cancer Inst. 91:1999;861-868
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 861-868
-
-
-
16
-
-
0005081642
-
Long term follow-up of patient with CLL receiving fludarabine regimens as initial therapy
-
Keating M.J., O'Brien S., Lerner S., Koller C., Beran M., Robertson L.E., et al. Long term follow-up of patient with CLL receiving fludarabine regimens as initial therapy. Blood. 92:1998;65-71
-
(1998)
Blood
, vol.92
, pp. 65-71
-
-
Keating, M.J.1
O'Brien, S.2
Lerner, S.3
Koller, C.4
Beran, M.5
Robertson, L.E.6
-
17
-
-
15844368449
-
Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. the French Cooperative Group on CLL
-
Johnson S., Smith A.G., Löffler H., Osby E., Juliusson G., Emmerich B., et al. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL. Lancet. 347:1996;1432-1438
-
(1996)
Lancet
, vol.347
, pp. 1432-1438
-
-
Johnson, S.1
Smith, A.G.2
Löffler, H.3
Osby, E.4
Juliusson, G.5
Emmerich, B.6
-
18
-
-
0034649696
-
Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
-
Rai K.R., Peterson B.L., Appelbaum F.R., Kolitz J., Elias L., Shepherd L., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 343:2000;1750-1757
-
(2000)
N Engl J Med
, vol.343
, pp. 1750-1757
-
-
Rai, K.R.1
Peterson, B.L.2
Appelbaum, F.R.3
Kolitz, J.4
Elias, L.5
Shepherd, L.6
-
19
-
-
0035889147
-
Randomized comparison of fludarabine, CAP, and CHOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
-
Leporrier M., Chevret S., Cazin B., Boudjerra N., Feugier P., Desablens B., et al. Randomized comparison of fludarabine, CAP, and CHOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood. 98:2001;2319-2325
-
(2001)
Blood
, vol.98
, pp. 2319-2325
-
-
Leporrier, M.1
Chevret, S.2
Cazin, B.3
Boudjerra, N.4
Feugier, P.5
Desablens, B.6
-
20
-
-
0027200169
-
Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent
-
Keating M.J., O'Brien S., Kantarjian H., Plunkett W., Estey E., Koller C., et al. Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Blood. 81:1993;2878-2884
-
(1993)
Blood
, vol.81
, pp. 2878-2884
-
-
Keating, M.J.1
O'Brien, S.2
Kantarjian, H.3
Plunkett, W.4
Estey, E.5
Koller, C.6
-
21
-
-
3242731873
-
Fludarabine induces higher response rates in first line therapy of older patients with advanced chronic lymphocytic leukemia than chlorambucil: Interim analysis of a phase III study of the German CLL Study Group
-
(abstr)
-
Eichhorst B.F., Busch R., Stauch M., Kneba M., Ritgen M., Söling U., et al. Fludarabine induces higher response rates in first line therapy of older patients with advanced chronic lymphocytic leukemia than chlorambucil Interim analysis of a phase III study of the German CLL Study Group. Blood. 102:2003;109. (abstr)
-
(2003)
Blood
, vol.102
, pp. 109
-
-
Eichhorst, B.F.1
Busch, R.2
Stauch, M.3
Kneba, M.4
Ritgen, M.5
Söling, U.6
-
22
-
-
0035890843
-
Activity of oral fludarabine phosphate in previously treated chronic lymphocytic leukemia
-
Boogaerts M.A., Van Hoof A., Catovsky D., Kovacs M., Montillo M., Zinzani P.L., et al. Activity of oral fludarabine phosphate in previously treated chronic lymphocytic leukemia. J Clin Oncol. 19:2001;4252-4258
-
(2001)
J Clin Oncol
, vol.19
, pp. 4252-4258
-
-
Boogaerts, M.A.1
Van Hoof, A.2
Catovsky, D.3
Kovacs, M.4
Montillo, M.5
Zinzani, P.L.6
-
23
-
-
0344783802
-
The effect of 2-h infusion of 2-chlorodeoxyadenosine (cladribine) with prednisone in previously untreated B-cell chronic lymphocytic leukaemia
-
Robak T., Blasinska-Morawiec M., Blonski J.Z., Krykowski E., Komarnicki M., Trepinska E., et al. The effect of 2-h infusion of 2-chlorodeoxyadenosine (cladribine) with prednisone in previously untreated B-cell chronic lymphocytic leukaemia. Eur J Cancer. 33:1997;2347-2351
-
(1997)
Eur J Cancer
, vol.33
, pp. 2347-2351
-
-
Robak, T.1
Blasinska-Morawiec, M.2
Blonski, J.Z.3
Krykowski, E.4
Komarnicki, M.5
Trepinska, E.6
-
24
-
-
0034667537
-
Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: Report of a prospective, randomized, multicenter trial
-
Robak T., Blonski J.Z., Kasznicki M., Blasinska-Morawiec M., Krykowski E., Dmoszynska A., et al. Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia Report of a prospective, randomized, multicenter trial. Blood. 96:2000;2723-2729
-
(2000)
Blood
, vol.96
, pp. 2723-2729
-
-
Robak, T.1
Blonski, J.Z.2
Kasznicki, M.3
Blasinska-Morawiec, M.4
Krykowski, E.5
Dmoszynska, A.6
-
25
-
-
0024551346
-
Pentostatin in chronic lymphocytic leukemia: A phase II trial of Cancer and Leukemia Group B
-
Dillman R.O., Mick R., McIntyre O.R. Pentostatin in chronic lymphocytic leukemia A phase II trial of Cancer and Leukemia Group B. J Clin Oncol. 7:1989;433-438
-
(1989)
J Clin Oncol
, vol.7
, pp. 433-438
-
-
Dillman, R.O.1
Mick, R.2
McIntyre, O.R.3
-
26
-
-
0025045158
-
Pentostatin in refractory chronic lymphocytic leukemia: A phase II trial of the European Organization for Research and Treatment of Cancer
-
Ho A.D., Thaler J., Stryckmans P., Coiffier B., Luciani M., Sonneveld P., et al. Pentostatin in refractory chronic lymphocytic leukemia A phase II trial of the European Organization for Research and Treatment of Cancer. J Natl Cancer Inst. 82:1990;1416-1420
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1416-1420
-
-
Ho, A.D.1
Thaler, J.2
Stryckmans, P.3
Coiffier, B.4
Luciani, M.5
Sonneveld, P.6
-
27
-
-
0027436016
-
Fludarabine: Pharmacokinetics, mechanisms of action, and rationales for combination therapies
-
Plunkett W., Gandhi V., Huang P., Robertson L.E., Yang L.Y., Gregoire V., et al. Fludarabine Pharmacokinetics, mechanisms of action, and rationales for combination therapies. Semin Oncol. 20:1993;2-12
-
(1993)
Semin Oncol
, vol.20
, pp. 2-12
-
-
Plunkett, W.1
Gandhi, V.2
Huang, P.3
Robertson, L.E.4
Yang, L.Y.5
Gregoire, V.6
-
28
-
-
0031841742
-
Clinical challenges in chronic lymphocytic leukemia
-
O'Brien S. Clinical challenges in chronic lymphocytic leukemia. Semin Hematol. 35:1998;22-26
-
(1998)
Semin Hematol
, vol.35
, pp. 22-26
-
-
O'Brien, S.1
-
29
-
-
0035282055
-
Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
-
O'Brien S.M., Kantarjian H.M., Cortes J., Beran M., Koller C.A., Giles F.J., et al. Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol. 19:2001;1414-1420
-
(2001)
J Clin Oncol
, vol.19
, pp. 1414-1420
-
-
O'Brien, S.M.1
Kantarjian, H.M.2
Cortes, J.3
Beran, M.4
Koller, C.A.5
Giles, F.J.6
-
30
-
-
2942569937
-
Fludarabine plus cyclophosphamide (FC) induces higher remission rates and longer progression free survival (PFS) than fludarabine (F) alone in first line therapy of advanced chronic lymphocytic leukemia (CLL) Results of a phase III study (CLL4 protocol) of the German CLL Study Group (GCLLSG)
-
(abstr)
-
Eichhorst B.F., Hopfinger G., Pasold R., Hensel M., Söling U., Siehl S., et al. Fludarabine plus cyclophosphamide (FC) induces higher remission rates and longer progression free survival (PFS) than fludarabine (F) alone in first line therapy of advanced chronic lymphocytic leukemia (CLL) Results of a phase III study (CLL4 protocol) of the German CLL Study Group (GCLLSG). Blood. 102:2003;72. (abstr)
-
(2003)
Blood
, vol.102
, pp. 72
-
-
Eichhorst, B.F.1
Hopfinger, G.2
Pasold, R.3
Hensel, M.4
Söling, U.5
Siehl, S.6
-
31
-
-
0034893776
-
Fludarabine plus cyclophosphamide is an efficient treatment for advanced chronic lymphocytic leukaemia (CLL) Results of a phase II study of the German CLL Study Group
-
Hallek M., Schmitt B., Wilhelm M., Busch R., Krober A., Fostitsch H.P., et al. Fludarabine plus cyclophosphamide is an efficient treatment for advanced chronic lymphocytic leukaemia (CLL) Results of a phase II study of the German CLL Study Group. Br J Haematol. 114:2001;342-348
-
(2001)
Br J Haematol
, vol.114
, pp. 342-348
-
-
Hallek, M.1
Schmitt, B.2
Wilhelm, M.3
Busch, R.4
Krober, A.5
Fostitsch, H.P.6
-
32
-
-
18744409028
-
Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukemia
-
Bosch F., Ferrer A., Lopez-Guillermo A., Gine E., Bellosillo B., Villamor N., et al. Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukemia. Br J Haematol. 119:2002;976-984
-
(2002)
Br J Haematol
, vol.119
, pp. 976-984
-
-
Bosch, F.1
Ferrer, A.2
Lopez-Guillermo, A.3
Gine, E.4
Bellosillo, B.5
Villamor, N.6
-
33
-
-
2942600289
-
Fludarabine, mitoxantrone and cyclophosphamide combination therapy in relapsed chronic lymphocytic leukaemia (CLL) with or without G-CSF: Results of a first interim analysis of a phase III study of the German CLL Study Group (GCLLSG)
-
(abstr)
-
Schmitt B.F., Burkhard O., Schlag R., Hopfinger G., Stauch M., Bergmann M., et al. Fludarabine, mitoxantrone and cyclophosphamide combination therapy in relapsed chronic lymphocytic leukaemia (CLL) with or without G-CSF Results of a first interim analysis of a phase III study of the German CLL Study Group (GCLLSG). Blood. 100:2002;364. (abstr)
-
(2002)
Blood
, vol.100
, pp. 364
-
-
Schmitt, B.F.1
Burkhard, O.2
Schlag, R.3
Hopfinger, G.4
Stauch, M.5
Bergmann, M.6
-
34
-
-
0029036444
-
Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia
-
Robertson L.E., O'Brien S., Kantarjian H., Koller C., Beran M., Andreeff M., et al. Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia. Leukemia. 9:1995;943-945
-
(1995)
Leukemia
, vol.9
, pp. 943-945
-
-
Robertson, L.E.1
O'Brien, S.2
Kantarjian, H.3
Koller, C.4
Beran, M.5
Andreeff, M.6
-
35
-
-
0345471455
-
Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia: A German multicenter phase II study
-
Rummel M.J., Kafer G., Pfreundschuh M., Jager E., Reinhardt U., Mitrou P.S., et al. Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia A German multicenter phase II study. Ann Oncol. 10:1999;183-188
-
(1999)
Ann Oncol
, vol.10
, pp. 183-188
-
-
Rummel, M.J.1
Kafer, G.2
Pfreundschuh, M.3
Jager, E.4
Reinhardt, U.5
Mitrou, P.S.6
-
36
-
-
3242713813
-
Fludarabine versus fludarabine plus epirubicin in the treatment of chronic lymphocytic leukemia (CLL) - Results of a randomized phase-III multicenter study
-
(abstr)
-
Rummel M.J., Gamm H., Rost A., Gruenhagen U., Wojatschek C., Jäger E., et al. Fludarabine versus fludarabine plus epirubicin in the treatment of chronic lymphocytic leukemia (CLL) - Results of a randomized phase-III multicenter study. Blood. 102:2002;437. (abstr)
-
(2002)
Blood
, vol.102
, pp. 437
-
-
Rummel, M.J.1
Gamm, H.2
Rost, A.3
Gruenhagen, U.4
Wojatschek, C.5
Jäger, E.6
-
37
-
-
0027323550
-
Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment
-
O'Brien S., Kantarjian H., Beran M., Smith T., Koller C., Estey E., et al. Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Blood. 82:1993;1695-1700
-
(1993)
Blood
, vol.82
, pp. 1695-1700
-
-
O'Brien, S.1
Kantarjian, H.2
Beran, M.3
Smith, T.4
Koller, C.5
Estey, E.6
-
38
-
-
0032189459
-
Infections in patients with chronic lymphocytic leukemia treated with fludarabine
-
Anaissie E.J., Kontoyiannis D.P., O'Brien S., Kantarjian H., Robertson L., Lerner S., et al. Infections in patients with chronic lymphocytic leukemia treated with fludarabine. Ann Intern Med. 129:1998;559-566
-
(1998)
Ann Intern Med
, vol.129
, pp. 559-566
-
-
Anaissie, E.J.1
Kontoyiannis, D.P.2
O'Brien, S.3
Kantarjian, H.4
Robertson, L.5
Lerner, S.6
-
39
-
-
0035880884
-
Impact of therapy with chlorambucil, fludarabine, or fludarabine plus chlorambucil on infections in patients with chronic lymphocytic leukemia: Intergroup Study Cancer and Leukemia Group B 9011
-
Morrison V.A., Rai K.R., Peterson B.L., Kolitz J.E., Elias L., Appelbaum F.R., et al. Impact of therapy with chlorambucil, fludarabine, or fludarabine plus chlorambucil on infections in patients with chronic lymphocytic leukemia Intergroup Study Cancer and Leukemia Group B 9011. J Clin Oncol. 19:2001;3611-3621
-
(2001)
J Clin Oncol
, vol.19
, pp. 3611-3621
-
-
Morrison, V.A.1
Rai, K.R.2
Peterson, B.L.3
Kolitz, J.E.4
Elias, L.5
Appelbaum, F.R.6
-
40
-
-
0028228008
-
Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: Clinical efficacy and modulation of arabinosylcytosine pharmacology
-
Gandhi V., Robertson L.E., Keating M.J., Plunkett W. Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia Clinical efficacy and modulation of arabinosylcytosine pharmacology. Cancer Chemother Pharmacol. 34:1994;30-36
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 30-36
-
-
Gandhi, V.1
Robertson, L.E.2
Keating, M.J.3
Plunkett, W.4
-
41
-
-
6444244331
-
Fludarabine, ara-C, novantrone and dexamethasone (FAND) in previously treated chronic lymphocytic leukemia patients
-
Mauro F.R., Foa R., Meloni G., Gentile M., Giammartini E., Giannarelli D., et al. Fludarabine, ara-C, novantrone and dexamethasone (FAND) in previously treated chronic lymphocytic leukemia patients. Haematologica. 87:2002;926-933
-
(2002)
Haematologica
, vol.87
, pp. 926-933
-
-
Mauro, F.R.1
Foa, R.2
Meloni, G.3
Gentile, M.4
Giammartini, E.5
Giannarelli, D.6
-
42
-
-
0032969980
-
Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2′-deoxyadenosine
-
Van Den Neste E., Bontemps F., Delacauw A., Cardoen S., Louviaux I., Scheiff J.M., et al. Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2′- deoxyadenosine. Leukemia. 13:1999;918-925
-
(1999)
Leukemia
, vol.13
, pp. 918-925
-
-
Van Den Neste, E.1
Bontemps, F.2
Delacauw, A.3
Cardoen, S.4
Louviaux, I.5
Scheiff, J.M.6
-
43
-
-
0036430207
-
Cladribine combined with cyclophosphamide is highly effective in the treatment of chronic lymphocytic leukemia
-
Robak T., Blonski J.Z., Kasznicki M., Gora-Tybor J., Dwilewicz-Trojaczek J., Stella-Holowiecka B., et al. Cladribine combined with cyclophosphamide is highly effective in the treatment of chronic lymphocytic leukemia. Hematol J. 3:2002;244-250
-
(2002)
Hematol J
, vol.3
, pp. 244-250
-
-
Robak, T.1
Blonski, J.Z.2
Kasznicki, M.3
Gora-Tybor, J.4
Dwilewicz-Trojaczek, J.5
Stella-Holowiecka, B.6
-
44
-
-
0037214931
-
Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia
-
Montillo M., Tedeschi A., O'Brien S., Di Raimondo F., Lerner S., Ferrajoli A., et al. Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia. Cancer. 97:2003;114-120
-
(2003)
Cancer
, vol.97
, pp. 114-120
-
-
Montillo, M.1
Tedeschi, A.2
O'Brien, S.3
Di Raimondo, F.4
Lerner, S.5
Ferrajoli, A.6
-
45
-
-
17944363286
-
A phase II study of sequential combination chemotherapy with cyclophosphamide, prednisone, and 2-chlorodeoxyadenosine in previously untreated patients with chronic lymphocytic leukemia
-
Tefferi A., Li C.Y., Reeder C.B., Geyer S.M., Allmer C., Levitt R., et al. A phase II study of sequential combination chemotherapy with cyclophosphamide, prednisone, and 2-chlorodeoxyadenosine in previously untreated patients with chronic lymphocytic leukemia. Leukemia. 15:2001;1171-1175
-
(2001)
Leukemia
, vol.15
, pp. 1171-1175
-
-
Tefferi, A.1
Li, C.Y.2
Reeder, C.B.3
Geyer, S.M.4
Allmer, C.5
Levitt, R.6
-
46
-
-
0034782484
-
Cladribine combined with cyclophosphamide and mitoxantrone as front-line therapy in chronic lymphocytic leukemia
-
Robak T., Blonski J.Z., Kasznicki M., Gora-Tybor I., Dwilewicz-Trojaczek J., Boguradzki P., et al. Cladribine combined with cyclophosphamide and mitoxantrone as front-line therapy in chronic lymphocytic leukemia. Leukemia. 15:2001;1510-1516
-
(2001)
Leukemia
, vol.15
, pp. 1510-1516
-
-
Robak, T.1
Blonski, J.Z.2
Kasznicki, M.3
Gora-Tybor, I.4
Dwilewicz-Trojaczek, J.5
Boguradzki, P.6
-
47
-
-
0035054979
-
Cladribine in combination with mitoxantrone and cyclophosphamide(CMC) in the treatment of heavily pre-treated patients with advanced indolent lymphoid malignancies
-
Robak T., Gora-Tybor J., Lech-Maranda E., Blonski J.Z., Kasznicki M. Cladribine in combination with mitoxantrone and cyclophosphamide(CMC) in the treatment of heavily pre-treated patients with advanced indolent lymphoid malignancies. Eur J Haematol. 66:2001;188-194
-
(2001)
Eur J Haematol
, vol.66
, pp. 188-194
-
-
Robak, T.1
Gora-Tybor, J.2
Lech-Maranda, E.3
Blonski, J.Z.4
Kasznicki, M.5
-
48
-
-
0036449340
-
High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas
-
Bremer K. High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas. J Cancer Res Clin Oncol. 128:2002;603-609
-
(2002)
J Cancer Res Clin Oncol
, vol.128
, pp. 603-609
-
-
Bremer, K.1
-
49
-
-
0036337956
-
Bendamustine in the treatment of chronic lymphocytic leukemia: Results and future perspectives
-
Aivado M., Schulte K., Henze L., Burger J., Finke J., Haas R. Bendamustine in the treatment of chronic lymphocytic leukemia Results and future perspectives. Semin Oncol. 29:(suppl 13):2002;19-22
-
(2002)
Semin Oncol
, vol.29
, Issue.SUPPL. 13
, pp. 19-22
-
-
Aivado, M.1
Schulte, K.2
Henze, L.3
Burger, J.4
Finke, J.5
Haas, R.6
-
50
-
-
3242711008
-
High efficacy and better hematological safety of reduced dose of bendamustin in extendedly pretreated patients with advanced, relapsed or refractory B-CLL: Phase I/II study of the German CLL Study Group
-
(abstr)
-
Bergmann M., Herold M., Wilhelm M., Emmerich B., Boening L., Hallek M. High efficacy and better hematological safety of reduced dose of bendamustin in extendedly pretreated patients with advanced, relapsed or refractory B-CLL Phase I/II study of the German CLL Study Group. Proc Am Soc Clin Oncol. 22:2003;590. (abstr)
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 590
-
-
Bergmann, M.1
Herold, M.2
Wilhelm, M.3
Emmerich, B.4
Boening, L.5
Hallek, M.6
-
52
-
-
0035351214
-
In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine
-
Chow K.U., Boehrer S., Geduldig K., Krapohl A., Hoelzer D., Mitrou P.S., et al. In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine. Haematologica. 86:2001;485-493
-
(2001)
Haematologica
, vol.86
, pp. 485-493
-
-
Chow, K.U.1
Boehrer, S.2
Geduldig, K.3
Krapohl, A.4
Hoelzer, D.5
Mitrou, P.S.6
-
53
-
-
0036200042
-
Bendamustine mitoxantrone and rituximab (BMR) a new effective regimen for refractory or relapsed indolent lymphomas
-
Weide R., Heymanns J., Gores A., Koppler H. Bendamustine mitoxantrone and rituximab (BMR) A new effective regimen for refractory or relapsed indolent lymphomas. Leuk Lymphoma. 43:2002;327-331
-
(2002)
Leuk Lymphoma
, vol.43
, pp. 327-331
-
-
Weide, R.1
Heymanns, J.2
Gores, A.3
Koppler, H.4
-
54
-
-
0040932434
-
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
-
Konig A., Schwartz G.K., Mohammad R.M., Al-Katib A., Gabrilove J.L. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood. 90:1997;4307-4312
-
(1997)
Blood
, vol.90
, pp. 4307-4312
-
-
Konig, A.1
Schwartz, G.K.2
Mohammad, R.M.3
Al-Katib, A.4
Gabrilove, J.L.5
-
55
-
-
0032533599
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
-
Byrd J.C., Shinn C., Waselenko J.K., Fuchs E.J., Lehman T.A., Nguyen P.L., et al. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood. 92:1998;3804-3816
-
(1998)
Blood
, vol.92
, pp. 3804-3816
-
-
Byrd, J.C.1
Shinn, C.2
Waselenko, J.K.3
Fuchs, E.J.4
Lehman, T.A.5
Nguyen, P.L.6
-
56
-
-
0034986264
-
UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism
-
Byrd J.C., Shinn C., Willis C.R., Flinn I.W., Lehman T., Sausville E., et al. UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism. Exp Hematol. 29:2001;703-708
-
(2001)
Exp Hematol
, vol.29
, pp. 703-708
-
-
Byrd, J.C.1
Shinn, C.2
Willis, C.R.3
Flinn, I.W.4
Lehman, T.5
Sausville, E.6
-
57
-
-
0024445695
-
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells
-
Drexler H.G., Gignac S.M., Jones R.A., Scott C.S., Pettit G.R., Hoffbrand A.V. Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells. Blood. 74:1989;1747-1757
-
(1989)
Blood
, vol.74
, pp. 1747-1757
-
-
Drexler, H.G.1
Gignac, S.M.2
Jones, R.A.3
Scott, C.S.4
Pettit, G.R.5
Hoffbrand, A.V.6
-
58
-
-
0031915022
-
Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: Preclinical studies
-
Mohammad R.M., Katato K., Almatchy V.P., Wall N., Liu K.Z., Schultz C.P., et al. Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine preclinical studies. Clin Cancer Res. 4:1998;445-453
-
(1998)
Clin Cancer Res
, vol.4
, pp. 445-453
-
-
Mohammad, R.M.1
Katato, K.2
Almatchy, V.P.3
Wall, N.4
Liu, K.Z.5
Schultz, C.P.6
-
59
-
-
3242688583
-
Phase I trial of bryostatin 1 (NSC 339555) and fludarabine in patients with chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma
-
(abstr)
-
Roberts J.D., Feldman E.J., Smith M.R., Grant S. Phase I trial of bryostatin 1 (NSC 339555) and fludarabine in patients with chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma. Blood. 100:2002;385. (abstr)
-
(2002)
Blood
, vol.100
, pp. 385
-
-
Roberts, J.D.1
Feldman, E.J.2
Smith, M.R.3
Grant, S.4
-
60
-
-
0033566643
-
Depsipeptide (FR901228) a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells
-
Byrd J.C., Shinn C., Ravi R., Willis C.R., Waselenko J.K., Flinn I.W., et al. Depsipeptide (FR901228) A novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells. Blood. 94:1999;1401-1408
-
(1999)
Blood
, vol.94
, pp. 1401-1408
-
-
Byrd, J.C.1
Shinn, C.2
Ravi, R.3
Willis, C.R.4
Waselenko, J.K.5
Flinn, I.W.6
-
61
-
-
0037531169
-
Phase I trial of the histone deacetylase inhibitor depsipeptide (FR901228) in fludarabine refractory chronic lymphocytic leukemia
-
(abstr)
-
Bruner R.J., Marcucci G., Binkley P., Xiao J., Chan K., Parthun M., et al. Phase I trial of the histone deacetylase inhibitor depsipeptide (FR901228) in fludarabine refractory chronic lymphocytic leukemia. Blood. 100:2002;385. (abstr)
-
(2002)
Blood
, vol.100
, pp. 385
-
-
Bruner, R.J.1
Marcucci, G.2
Binkley, P.3
Xiao, J.4
Chan, K.5
Parthun, M.6
-
62
-
-
0038494686
-
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein
-
Aron J.L., Parthun M.R., Marcucci G., Kitada S., Mone A.P., Davis M.E., et al. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood. 102:2003;652-658
-
(2003)
Blood
, vol.102
, pp. 652-658
-
-
Aron, J.L.1
Parthun, M.R.2
Marcucci, G.3
Kitada, S.4
Mone, A.P.5
Davis, M.E.6
-
63
-
-
0037396217
-
Oblimersen sodium (G3139 Bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia: A targeted approach to enhance apoptosis
-
Frankel S.R. Oblimersen sodium (G3139 Bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia A targeted approach to enhance apoptosis. Semin Oncol. 30:2003;300-304
-
(2003)
Semin Oncol
, vol.30
, pp. 300-304
-
-
Frankel, S.R.1
-
64
-
-
0013253465
-
Genasense (Bcl-2 Antisense) monotherapy in patients with relapsed or refractory chronic lymphocytic leukemia: Phase I and II results
-
(abstr)
-
Rai K.R., O'Brien S., Cunningham C., Turkina A.G., Ochoa L., Frankel S.R., et al. Genasense (Bcl-2 Antisense) monotherapy in patients with relapsed or refractory chronic lymphocytic leukemia Phase I and II results. Blood. 100:2002;384. (abstr)
-
(2002)
Blood
, vol.100
, pp. 384
-
-
Rai, K.R.1
O'Brien, S.2
Cunningham, C.3
Turkina, A.G.4
Ochoa, L.5
Frankel, S.R.6
-
66
-
-
0030696074
-
Fludarabine and granulocyte colony-stimulating factor (G-CSF) in patients with chronic lymphocytic leukemia
-
O'Brien S., Kantarjian H., Beran M., Koller C., Talpaz M., Lerner S., et al. Fludarabine and granulocyte colony-stimulating factor (G-CSF) in patients with chronic lymphocytic leukemia. Leukemia. 11:1997;1631-1635
-
(1997)
Leukemia
, vol.11
, pp. 1631-1635
-
-
O'Brien, S.1
Kantarjian, H.2
Beran, M.3
Koller, C.4
Talpaz, M.5
Lerner, S.6
-
67
-
-
0034235909
-
Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies
-
Flinn I.W., Byrd J.C., Morrison C., Jamison J., Diehl L.F., Murphy T., et al. Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies. Blood. 96:2000;71-75
-
(2000)
Blood
, vol.96
, pp. 71-75
-
-
Flinn, I.W.1
Byrd, J.C.2
Morrison, C.3
Jamison, J.4
Diehl, L.F.5
Murphy, T.6
-
68
-
-
0035126147
-
Correction of disease related anaemia of B-chronic lymphoproliferative disorders by recombinant human erythropoietin: Maintenance is necessary to sustain response
-
Siakantaris M.P., Angelopoulou M.K., Vassilakopoulos T.P., Dimopoulo M.N., Kontopidou F.N., Pangalis G.A. Correction of disease related anaemia of B-chronic lymphoproliferative disorders by recombinant human erythropoietin Maintenance is necessary to sustain response. Leuk Lymphoma. 40:2000;141-147
-
(2000)
Leuk Lymphoma
, vol.40
, pp. 141-147
-
-
Siakantaris, M.P.1
Angelopoulou, M.K.2
Vassilakopoulos, T.P.3
Dimopoulo, M.N.4
Kontopidou, F.N.5
Pangalis, G.A.6
-
69
-
-
0037093196
-
Randomized, double-blind, placebo-controlled trial of recombinant human erythropoietin, epoetin Beta, in hematologic malignancies
-
Osterborg A., Brandberg Y., Molostova V., Iosava G., Abdulkadyrov K., Hedenus M., et al. Randomized, double-blind, placebo-controlled trial of recombinant human erythropoietin, epoetin Beta, in hematologic malignancies. J Clin Oncol. 20:2002;2486-2494
-
(2002)
J Clin Oncol
, vol.20
, pp. 2486-2494
-
-
Osterborg, A.1
Brandberg, Y.2
Molostova, V.3
Iosava, G.4
Abdulkadyrov, K.5
Hedenus, M.6
-
70
-
-
0036097014
-
Downstaging Rai stage III B-chronic lymphocytic leukemia patients with the administration of recombinant human erythropoietin
-
Pangalis G.A., Siakantaris M.P., Angelopoulou M.K., Vassilakopoulos T.P., Dimopoulou M.N., Kyrtsonis M.C., et al. Downstaging Rai stage III B-chronic lymphocytic leukemia patients with the administration of recombinant human erythropoietin. Haematologica. 87:2002;500-506
-
(2002)
Haematologica
, vol.87
, pp. 500-506
-
-
Pangalis, G.A.1
Siakantaris, M.P.2
Angelopoulou, M.K.3
Vassilakopoulos, T.P.4
Dimopoulou, M.N.5
Kyrtsonis, M.C.6
-
71
-
-
0036049054
-
Management of disease-related anemia in patients with multiple myeloma or chronic lymphocytic leukemia: Epoetin treatment recommendations
-
Ludwig H., Rai K., Blade J., Dammacco F., Degos L., Itri L., et al. Management of disease-related anemia in patients with multiple myeloma or chronic lymphocytic leukemia Epoetin treatment recommendations. Hematol J. 3:2002;121-130
-
(2002)
Hematol J
, vol.3
, pp. 121-130
-
-
Ludwig, H.1
Rai, K.2
Blade, J.3
Dammacco, F.4
Degos, L.5
Itri, L.6
-
72
-
-
0034010518
-
Measuring comorbidity in older cancer patients
-
Extermann M. Measuring comorbidity in older cancer patients. Eur J Cancer. 36:2000;453-471
-
(2000)
Eur J Cancer
, vol.36
, pp. 453-471
-
-
Extermann, M.1
-
73
-
-
3242739926
-
Comprehensive geriatric evaluation in elderly patients with lymphoma: Feasibility of a patient-tailored treatment plan
-
Bernardi D., Milan I., Balzarotti M., Spina M., Santoro A., Tirelli U. Comprehensive geriatric evaluation in elderly patients with lymphoma Feasibility of a patient-tailored treatment plan. J Clin Oncol. 24:2003;754-756
-
(2003)
J Clin Oncol
, vol.24
, pp. 754-756
-
-
Bernardi, D.1
Milan, I.2
Balzarotti, M.3
Spina, M.4
Santoro, A.5
Tirelli, U.6
-
74
-
-
0037085770
-
Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
-
Kennedy B., Rawstron A., Carter C., Ryan M., Speed K., Lucas G., et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood. 99:2002;2245-2247
-
(2002)
Blood
, vol.99
, pp. 2245-2247
-
-
Kennedy, B.1
Rawstron, A.2
Carter, C.3
Ryan, M.4
Speed, K.5
Lucas, G.6
-
75
-
-
0037522837
-
A high proportion of molecular remission can be obtained with a fludarabine, cyclophosphamide, rituximab combination (FCR) in chronic lymphocytic leukaemia
-
(abstr)
-
Keating M., Manshouri T., O'Brien S., Wierda W., Kantarijan H., Washington L., et al. A high proportion of molecular remission can be obtained with a fludarabine, cyclophosphamide, rituximab combination (FCR) in chronic lymphocytic leukaemia. Blood. 100:2002;205. (abstr)
-
(2002)
Blood
, vol.100
, pp. 205
-
-
Keating, M.1
Manshouri, T.2
O'Brien, S.3
Wierda, W.4
Kantarijan, H.5
Washington, L.6
-
76
-
-
31544469934
-
Oral fludarabine and cyclophosphamide in previously untreated chronic lymphocytic leukaemia (CLL) Preliminary data on 75 patients
-
(abstr)
-
Cazin B., Maloum K., Divine M., Lepretre S., Travade P., Delmer A., et al. Oral fludarabine and cyclophosphamide in previously untreated chronic lymphocytic leukaemia (CLL) Preliminary data on 75 patients. Blood. 100:2002;200. (abstr)
-
(2002)
Blood
, vol.100
, pp. 200
-
-
Cazin, B.1
Maloum, K.2
Divine, M.3
Lepretre, S.4
Travade, P.5
Delmer, A.6
-
77
-
-
31544480521
-
Fludarabine and cyclophosphamide achieves high complete response rate in patients with previously untreated chronic lymphocytic leukemia: ECOG 1997
-
(abstr)
-
Flinn I.W., Jemiai Y., Bennett J.M., Falkson C.I., Flynn P., Pundaleeka S., et al. Fludarabine and cyclophosphamide achieves high complete response rate in patients with previously untreated chronic lymphocytic leukemia ECOG 1997. Blood. 98:2001;150. (abstr)
-
(2001)
Blood
, vol.98
, pp. 150
-
-
Flinn, I.W.1
Jemiai, Y.2
Bennett, J.M.3
Falkson, C.I.4
Flynn, P.5
Pundaleeka, S.6
-
78
-
-
0030456923
-
Purine analogs in chronic lymphocytic leukemia and Waldenstrom's macroglobulinemia
-
O'Brien S., Kantarjian H., Keating M.J. Purine analogs in chronic lymphocytic leukemia and Waldenstrom's macroglobulinemia. Ann Oncol. 7:(suppl):1996;27-33
-
(1996)
Ann Oncol
, vol.7
, Issue.SUPPL.
, pp. 27-33
-
-
O'Brien, S.1
Kantarjian, H.2
Keating, M.J.3
-
79
-
-
0033406619
-
Sequential cis-platinum and fludarabine with or without arabinosyl cytosine in patients failing prior fludarabine therapy for chronic lymphocytic leukemia: A phase II study
-
cytic leukemia: A phase II study. Leuk Lymphoma 36:57-65, 1999
-
Giles F.J., O'Brien S., Santini V., Gandhi V., Plunkett W., Seymour J.F., et al. Sequential cis-platinum and fludarabine with or without arabinosyl cytosine in patients failing prior fludarabine therapy for chronic lymphocytic leukemia A phase II study. Leuk Lymphoma. 36:1999;57-65. cytic leukemia: A phase II study. Leuk Lymphoma 36:57-65, 1999
-
(1999)
Leuk Lymphoma
, vol.36
, pp. 57-65
-
-
Giles, F.J.1
O'Brien, S.2
Santini, V.3
Gandhi, V.4
Plunkett, W.5
Seymour, J.F.6
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