Protective effect of naringin against ischemic reperfusion cerebral injury: Possible neurobehavioral, biochemical and cellular alterations in rat brain

European Journal of Pharmacology

Volumn 616, Issue 1-3, 2009, Pages 147-154

  Gaur, Vaibhav ^a   Aggarwal, Aditi ^a   Kumar, Anil ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

BCCAO (bilateral common carotid artery occlusion); Ischemia; Naringin; Oxidative stress; Respiratory enzyme activity

Indexed keywords

AURANTIIN; CATALASE; GLUTATHIONE; MITOCHONDRIAL ENZYME; NITRITE; SUPEROXIDE DISMUTASE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; COGNITION; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; HIPPOCAMPUS; HISTOPATHOLOGY; LIPID PEROXIDATION; LOCOMOTION; MALE; NEUROCHEMISTRY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN INJURIES; CELL RESPIRATION; FLAVANONES; GLUTATHIONE; MALE; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 67651099137     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.056     Document Type: Article

References (57)

1. Allen K.L., Almeida A., Bates T.E., and Clark J.B. Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia. J. Neurochem. 64 (1995) 2222-2229
2. Almeida A., Allen K.L., Bates T.E., and Clark J.B. Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J. Neurochem. 65 (1995) 1698-1703
3. Alonso D., Serrano J., Rodriguez I., Ruiz-Cabello J., Fernandez A.P., Encinas J.M., et al. Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex. J. Comp. Neurol. 443 (2002) 183-200
4. Bederson J.B., Pitts L.H., Tsuji M., Nishimur M.C., Davis R.L., and Bartowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
5. Berman S.B., and Hastings T.G. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J. Neurochem. 73 (1999) 1127-1137
6. Bok S.H., Lee S.H., Park Y.B., Bae K.H., Son K.H., Jeong T.S., and Choi M.S. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and Acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J. Nutr. 129 (1999) 1182-1185
7. Bromont C., Marie C., and Bralet J. Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke 20 (1989) 918-924
8. Chemerinski E., and Robinson R.G. The neuropsychiatry of stroke. Psychosomatics 41 (2000) 5-14
9. Chen Y.T., Zheng R.L., Jia Z.J., and Ju Y. Flavonoids as superoxide scavengers and antioxidants. Free Radic. Biol. Med. 9 (1990) 19-21
10. Choe S.C., Kim H.S., Jeong T.S., Bok S.H., and Park T.B. Naringin as an anti-atherogenic effect with the inhibition of intracellular adhesion molecule-1 in hypercholesterolemic rabbits. J. Cardiovasc. Pharmacol. 38 (2001) 947-955
11. Choi M.S., Do K.M., Park Y.B., Jeon S.M., Jeong T.S., Lee Y.K., Lee M.K., and Bok S.H. Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. Ann. Nutr. Metab. 45 (2001) 193-201
12. Cramer S.C. Neurological progress repairing the human brain after stroke: I mechanisms of spontaneous recovery. Ann. Neurol. 63 (2008) 272-287
13. Cruz R., Almaguer M.W., and Bergado Rosado J.A. Glutathione in cognitive function and neurodegeneration. Rev. Neurol. 36 (2003) 877-886
14. del Zoppo G.J. Stroke and neurovascular protection. N. Eng. J. Med. 354 (2006) 553-555
15. Dobkin B.H. The rehabilitation of elderly stroke patients. Clin. Geriatr. Med. 7 (1991) 507-523
16. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82 (1959) 70-77
17. Feeney D.M., Boyeson M.G., Linn R.T., Murray H.M., and Dail W.G. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res. 211 (1981) 67-77
18. Gornall A.G., Bardawill C.J., and David M.M. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177 (1949) 751-766
19. Green L.C., Wagner D.A., and Glagowski J. Analysis of nitrate, nitrite and (15N) nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
20. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
21. Higashimoto M., Yamato H., Kinouchi T., and Ohnishi Y. Inhibitory effects of citrus fruits on the mutagenicity of 1-methyl-1, 2, 3, 4-tetrahydro-beta-carboline-3-carboxylic acid treated with nitrite in the presence of ethanol. Mutat. Res. 415 (1998) 219-226
22. Hunter A.J., Hatcher J., Virley D., Nelson P., Irving E., Handubgham S.J., and Parsons A.A. Functional assessments in mice and rats after focal stroke. Neuropharmacology 39 (2000) 806-816
23. Jagetia G.C., and Reddy T.K. The grapefruit flavonone naringin, protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. Mutat. Res. 519 (2002) 37-48
24. Jenkins L.W., Povlishock J.T., Lewelt W., Miller J.D., and Becker D.P. The role of postischemic recirculation in the development of ischemic neuronal injury following complete cerebral ischemia. Acta Neuropathol. 55 (1981) 205-220
25. Jeon S.M., Bok S.H., Jang M.K., Lee M.K., Nam K.T., Park Y.B., Rhee S.J., and Choi M.S. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci. 69 (2001) 2855-2866
26. Jeon S.M., Park Y.B., and Choi M.S. Antihypercholesterolaemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clin. Nutr. 23 (2004) 1025-1034
27. Jeyaseelan K., Lim K.Y., and Armugam A. Neuroprotectants in stroke therapy. Expert Opin. Pharmacother. 9 (2008) 887-900
28. Jingtao J., Sato S., and Yamanaka N. Changes in cerebral blood flow and blood brain barrier in the gerbil hippocampal CA1 region following repeated brief cerebral ischemia. Med. Electron Microsc. 32 (1999) 175-183
29. Jung U.J., Kim H.J., Lee J.S., Lee M.K., Kim H.O., Park E.J., Kim H.K., Jeong T.S., and Choi M.S. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin. Nutr. 22 (2003) 561-568
30. Kim D.H., Jung E.A., Song I.S., Han J.A., Kim T.H., and Han M.J. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch. Pharmacol. Res. 21 (1998) 17-23
31. King T.E. Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. Methods Enzymol. 10 (1967) 322-331
32. King T.E., and Howard R.L. Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol. 10 (1967) 275-294
33. Kondo T., Reaume A.G., Huang T.T., Carlson E., Murakami K., Chen S.F., Richard E., Scott W., Epstein C.J., and Chan P.H. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J. Neurosci. 17 (1997) 4180-4189
34. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch. Biochem. Biophys. 186 (1978) 189-195
35. Luck H. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis (1971), Academic Press, New York 885-893
36. Madl C., and Holzer M. Brain function after resuscitation from cardiac arrest. Curr. Opin. Crit. Care 10 (2004) 213-217
37. Maher P. The effects of stress and aging on glutathione metabolism. Ageing Res. Rev. 4 (2005) 288-314
38. Marchand L.Le., Murphy S.P., Hankin J.H., Wilkens L.R., and Kolonel L.N. Intake of flavonoids and lung cancer. J. Natl. Cancer Inst. 92 (2000) 154-160
39. Maxwell S.R.J. Prospects for the use of antioxidant therapies. Drugs 49 (1995) 345-361
40. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312 (1985) 159-163
41. Mosmann T. Rapid colorimetric assay for cellular growth survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
42. Mukherjee P.K., Ahamed K.F.H.N., Kumar V., Mukherjee K., and Houghton P.J. Protective effect of biflavones from Araucaria bidwillii Hook in rat cerebral ischemia/reperfusion induced oxidative stress. Behav. Brain Res. 178 (2007) 221-228
43. Nelson C., and Silverstein F.S. Acute disruption of cytochrome oxidase activity in brain in a perinatal rat stroke model. Pediatr. Res. 36 (1994) 12-19
44. Reddy D.S., and Kulkarni S.K. Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging and dizocilpine-induced learning impairment. Brain Res. 799 (1998) 215-229
45. Rehni A.K., and Singh N. Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice. Pharmacol. Rep. 59 (2007) 192-198
46. Ryter S.W., and Choi A.M. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxid. Redox Signal. 7 (2005) 80-91
47. Seif-El-Nasr M., and Abd-El-Fattah A.A. Lipid peroxide, phospholipids, glutathione levels and superoxide dismutase activity in rat brain after ischaemia: effect of Ginkgo biloba extract. Pharmacol. Res. 32 5 (1995) 273-278
48. Shaheen A.A., Abd-el-Fattah A.A., and Seif-el-Nasr M. Influence of verapamil on the efficacy of vitamin E in preventing the ischemia-reperfusion-induced biochemical dearrangement in cerebral cortex of rat. Arzneimittel-Forschung 46 (1996) 670-673
49. Sims N.R. Selective impairment of respiration in mitochondria isolated from brain sub regions following transient forebrain ischemia in the rat. J. Neurochem. 56 (1991) 1836-1844
50. Sottocasa G.L., Kuylenstierna B., Ernster L., and Berqstrand A. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J. Cell. Biol. 32 (1967) 415-438
51. Swiader K.E., and Zarawska E. Flavonoids of rare Artemesia species and their antifungal properties. Fitoterapia 67 (1996) 77-78
52. Tsai S.H., Lin-Shiau S.Y., and Lin J.K. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br. J. Pharmacol. 126 (1999) 673-680
53. ++-antagonist drugs. Ital. J. Biochem. 39 (1990) 196A-198A
54. Wills E.D. Mechanism of lipid peroxide formation in animal tissues. Biochem. J. 99 (1966) 667-676
55. Xia Y., and Zweier J.L. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J. Biol. Chem. 270 (1995) 18797-18803
56. Yan B., Bi X., He J., Zhang Y., Thakur S., Xu H., Gendron A., Kong J., and Li X. Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occlusion in mice. Life Sci. 81 (2007) 353-361
57. Zahler W.L., and Cleland W.W. A specific and sensitive assay for disulfides. J. Biol. Chem. 243 (1968) 716-719