Optical coherence tomography: History, current status, and laboratory work

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 5, 2011, Pages 2425-2436

  Gabriele, Michelle L ^a,b,c   Wollstein, Gadi ^a   Ishikawa, Hiroshi ^a,b   Kagemann, Larry ^a,b   Xu, Juan ^a   Folio, Lindsey S ^a   Schuman, Joel S ^a,b,c,d  

^a University of Pittsburgh School of Medicine   (United States)

^b University of Pittsburgh   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY; ANTERIOR EYE SEGMENT; EYE TRACKING OPTICAL COHERENCE TOMOGRAPHY; GLAUCOMA; HISTORY; HUMAN; IMAGING; NONHUMAN; OPHTHALMOLOGY; OPTICAL COHERENCE TOMOGRAPHY; POLARIZATION SENSITIVE OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA; REVIEW; SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY; TECHNOLOGY;

ANIMALS; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; EYE DISEASES; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 79956015900     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6312     Document Type: Review

References (186)

1. Fercher AF, Mengedoht K, Werner W. Eye-length measurement by interferometry with partially coherent light. Opt Lett. 1988; 13:186-188.
2. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991;254:1178-1181.
3. Fercher AF, Hitzenberger CK, Drexler W, Kamp G, Sattmann H. In vivo optical coherence tomography. Am J Ophthalmol. 1993; 116:113-114.
4. Puliafito CA, Hee MR, Lin CP, et al. Imaging of macular diseases with optical coherence tomography. Ophthalmology. 1995;102: 217-229.
5. Hee MR, Izatt JA, Swanson EA, et al. Optical coherence tomography of the human retina. Arch Ophthalmol. 1995;113:325-332.
6. Izatt JA, Hee MR, Swanson EA, et al. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch Ophthalmol. 1994;112:1584-1589.
7. Swanson EA, Izatt JA, Hee MR, et al. In vivo retinal imaging by optical coherence tomography. Opt Lett. 1993;18:1864-1866.
8. Schuman JS, Hee MR, Arya AV, et al. Optical coherence tomography: a new tool for glaucoma diagnosis. Curr Opin Ophthalmol. 1995;6:89-95.
9. Schuman JS, Hee MR, Puliafito CA, et al. Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. Arch Ophthalmol. 1995;113: 586-596.
10. Schuman JS, Pedut-Kloizman T, Hertzmark E, et al. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology. 1996;103:1889-1898.
11. Drexler W, Morgner U, Kartner FX, et al. In vivo ultrahighresolution optical coherence tomography. Opt Lett. 1999;24: 1221-1223.
12. Lim H, Jiang Y, Wang Y, Huang YC, Chen Z, Wise FW. Ultrahighresolution optical coherence tomography with a fiber laser source at 1 microm. Opt Lett. 2005;30:1171-1173.
13. Unterhuber A, Povazay B, Bizheva K, et al. Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography. Phys Med Biol. 2004;49:1235-1246.
14. Wojtkowski M, Leitgeb R, Kowalczyk A, Bajraszewski T, Fercher A. In vivo human retinal imaging by Fourier-domain optical coherence tomography. J Biomed Opt. 2002;7:457-463.
15. Fercher A, Hitzenberger C, Kamp G, Elzaiat S. Measurement of intraocular distances by backscattering spectral interferometry. Opt Commun. 1995;117:43-48.
16. Choma MA, Hsu K, Izatt JA. Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source. J Biomed Opt. 2005;10:44009.
17. de Boer JF, Cense B, Park BH, Pierce MC, Tearney GJ, Bouma BE. Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Opt Lett. 2003;28: 2067-2069.
18. Leitgeb R, Wojtkowski M, Kowalczyk A, Hitzenberger CK, Sticker M, Fercher AF. Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography. Opt Lett. 2000;25:820-822.
19. Nassif N, Cense B, Park BH, et al. In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. Opt Lett. 2004;29:480-482.
20. Wojtkowski M, Srinivasan V, Fujimoto JG, et al. Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology. 2005;112:1734-1746.
21. Zhang J, Rao B, Chen Z. Swept source based fourier domain functional optical coherence tomography. Conf Proc IEEE Eng Med Biol Soc. 2005;7:7230-7233.
22. Yun SH, Tearney G, de Boer J, Bouma B. Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts. Opt Express. 2004;12:5614-5624.
23. Choma M, Sarunic M, Yang C, Izatt J. Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Opt Express. 2003;11:2183-2189.
24. Drexler W, Morgner U, Ghanta RK, Kartner FX, Schuman JS, Fujimoto JG. Ultrahigh-resolution ophthalmic optical coherence tomography. Nat Med. 2001;7:502-507.
25. Leitgeb R, Hitzenberger C, Fercher A. Performance of fourier domain vs. time domain optical coherence tomography. Opt Express. 2003;11:889-894.
26. Potsaid B, Gorczynska I, Srinivasan VJ, et al. Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second. Opt Express. 2008;16:15149-15169.
27. Srinivasan VJ, Adler DC, Chen Y, et al. Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci. 2008;49:5103-5110.
28. Bowd C, Weinreb RN, Williams JM, Zangwill LM. The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography. Arch Ophthalmol. 2000;118:22-26.
29. Bowd C, Zangwill LM, Berry CC, et al. Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function. Invest Ophthalmol Vis Sci. 2001;42:1993-2003.
30. Hoh ST, Greenfield DS, Mistlberger A, Liebmann JM, Ishikawa H, Ritch R. Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes. Am J Ophthalmol. 2000;129:129-135.
31. Mistlberger A, Liebmann JM, Greenfield DS, et al. Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology. 1999;106:2027-2032.
32. Pieroth L, Schuman JS, Hertzmark E, et al. Evaluation of focal defects of the nerve fiber layer using optical coherence tomography. Ophthalmology. 1999;106:570-579.
33. Zangwill LM, Williams J, Berry CC, Knauer S, Weinreb RN. A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma. Ophthalmology. 2000;107:1309-1315.
34. Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS. Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol. 2005; 139:39-43.
35. Schuman JS. Spectral domain optical coherence tomography for glaucoma (an AOS thesis). Trans Am Ophthalmol Soc. 2008;106: 426-458.
36. Kim JS, Ishikawa H, Sung KR, et al. Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography. Br J Ophthalmol. 2009; 93:1057-1063.
37. Gabriele ML, Ishikawa H, Wollstein G, et al. Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning. Invest Ophthalmol Vis Sci. 2007;48:3154-3160.
38. Ishikawa H, Stein DM, Wollstein G, Beaton S, Fujimoto JG, Schuman JS. Macular segmentation with optical coherence tomography. Invest Ophthalmol Vis Sci. 2005;46:2012-2017.
39. Kim JS, Ishikawa H, Gabriele ML, et al. Retinal nerve fiber layer thickness measurement comparability between time domain optical coherence tomography (OCT) and spectral domain OCT. Invest Ophthalmol Vis Sci. 2010;51:896-902.
40. Jorgensen TM, Thomadsen J, Christensen U, Soliman W, Sander B. Enhancing the signal-to-noise ratio in ophthalmic optical coherence tomography by image registration-method and clinical examples. J Biomed Opt. 2007;12:041208.
41. Ramrath L, Moreno G, Mueller H, Bonin T, Huettmann G, Schweikard A. Towards multi-directional OCT for speckle noise reduction. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2008;11:815-823.
42. Ricco S, Chen M, Ishikawa H, Wollstein G, Schuman JS. Correcting motion artifacts in retinal spectral domain optical coherence tomography via image registration. Med Image Comput Comput Assist Interv Proceed. 2009;5761:100-107.
43. Xu J, Ishikawa H, Wollstein G, Schuman JS. Retinal vessel segmentation on SLO image. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2258-2261.
44. Ferguson RD, Hammer DX, Paunescu LA, Beaton S, Schuman JS. Tracking optical coherence tomography. Opt Lett. 2004;29: 2139-2141.
45. Hammer DX, Ferguson RD, Magill JC, et al. Active retinal tracker for clinical optical coherence tomography systems. J Biomed Opt. 2005;10:024038.
46. Ishikawa H, Gabriele ML, Wollstein G, et al. Retinal nerve fiber layer assessment using optical coherence tomography with active optic nerve head tracking. Invest Ophthalmol Vis Sci. 2006;47: 964-967.
47. Cense B, Chen TC, Park BH, Pierce MC, de Boer JF. In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography. J Biomed Opt. 2004;9:121-125.
48. Cense B, Chen TC, Park BH, Pierce MC, de Boer JF. Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2004;45:2606-2612.
49. Yamanari M, Miura M, Makita S, Yatagai T, Yasuno Y. Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry. J Biomed Opt. 2008;13:014013.
50. Gupta V, Gupta P, Singh R, Dogra MR, Gupta A. Spectral-domain Cirrus high-definition optical coherence tomography is better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis. Am J Ophthalmol. 2008;145:1018-1022.
51. Koizumi H, Spaide RF, Fisher YL, Freund KB, Klancnik JM Jr, Yannuzzi LA. Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;145:509-517.
52. Mojana F, Cheng L, Bartsch DU, et al. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol. 2008;146:218-227.
53. Punjabi OS, Flynn HW Jr, Knighton RW, et al. Spectral domain optical coherence tomography for proliferative diabetic retinopathy with subhyaloid hemorrhage. Ophthalmic Surg Lasers Imaging. 2008;39:494-496.
54. Schmidt-Erfurth U, Leitgeb RA, Michels S, et al. Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. Invest Ophthalmol Vis Sci. 2005;46:3393-3402.
55. Srinivasan VJ, Wojtkowski M, Witkin AJ, et al. High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology. 2006;113:2054 e2051-2014.
56. Oh J, Smiddy WE, Flynn HW Jr, Gregori G, Lujan B. Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery. Invest Ophthalmol Vis Sci. 2010;51:1651-1658.
57. Sano M, Shimoda Y, Hashimoto H, Kishi S. Restored photoreceptor outer segment and visual recovery after macular hole closure. Am J Ophthalmol. 2009;147:313-318 e311.
58. Inoue M, Watanabe Y, Arakawa A, Sato S, Kobayashi S, Kadonosono K. Spectral-domain optical coherence tomography images of inner/outer segment junctions and macular hole surgery outcomes. Graefes Arch Clin Exp Ophthalmol. 2009;247:325-330.
59. Chung EJ, Lew YJ, Lee H, Koh HJ. OCT-guided hyaloid release for vitreomacular traction syndrome. Korean J Ophthalmol. 2008; 22:169-173.
60. Falkner-Radler CI, Glittenberg C, Binder S. Spectral domain highdefinition optical coherence tomography in patients undergoing epiretinal membrane surgery. Ophthalmic Surg Lasers Imaging. 2009;40:270-276.
61. Michalewska Z, Michalewski J, Cisiecki S, Adelman R, Nawrocki J. Correlation between foveal structure and visual outcome following macular hole surgery: a spectral optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol. 2008;246:823-830.
62. Uchino E, Uemura A, Doi N, Ohba N. Postsurgical evaluation of idiopathic vitreomacular traction syndrome by optical coherence tomography. Am J Ophthalmol. 2001;132:122-123.
63. Chang LK, Fine HF, Spaide RF, Koizumi H, Grossniklaus HE. Ultrastructural correlation of spectral-domain optical coherence tomographic findings in vitreomacular traction syndrome. Am J Ophthalmol. 2008;146:121-127.
64. Sayegh RG, Georgopoulos M, Geitzenauer W, Simader C, Kiss C, Schmidt-Erfurth U. High-resolution optical coherence tomography after surgery for vitreomacular traction: a 2-year follow-up. Ophthalmology. 2010;117:2010-2017-e1-2.
65. Freeman SR, Kozak I, Cheng L, et al. Optical coherence tomography-raster scanning and manual segmentation in determining drusen volume in age-related macular degeneration. Retina. 2010;30:431-435.
66. Yi K, Mujat M, Park BH, et al. Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration. Br J Ophthalmol. 2009;93:176-181.
67. Cabrera DeBuc D, Somfai GM. Early detection of retinal thickness changes in diabetes using optical coherence tomography. Med Sci Monit. 2010;16:MT15-MT21.
68. van Dijk HW, Kok PH, Garvin M, et al. Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009;50:3404-3409.
69. Huang J, Liu X, Wu Z, et al. Macular and retinal nerve fiber layer thickness measurements in normal eyes with the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000. J Glaucoma. 2011;20:118-125.
70. Koleva-Georgieva D, Sivkova N. Assessment of serous macular detachment in eyes with diabetic macular edema by use of spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2009;247:1461-1469.
71. Arichika S, Hangai M, Yoshimura N. Correlation between thickening of the inner and outer retina and visual acuity in patients with epiretinal membrane. Retina. 2010;30:503-508.
72. Nunes S, Pereira I, Santos A, Bernardes R, Cunha-Vaz J. Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME. Br J Ophthalmol. 2010;94:1201-1204.
73. Patel PJ, Chen FK, da Cruz L, Tufail A. Segmentation error in Stratus optical coherence tomography for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:399-404.
74. Sadda SR, Wu Z, Walsh AC, et al. Errors in retinal thickness measurements obtained by optical coherence tomography. Ophthalmology. 2006;113:285-293.
75. Keane PA, Mand PS, Liakopoulos S, Walsh AC, Sadda SR. Accuracy of retinal thickness measurements obtained with Cirrus optical coherence tomography. Br J Ophthalmol. 2009;93:1461-1467.
76. Giani A, Cigada M, Esmaili DD, et al. Artifacts in automatic retinal segmentation using different optical coherence tomography instruments. Retina. 2010;30:607-616.
77. Ishikawa H, Kim J, Friberg TR, et al. Three-dimensional optical coherence tomography (3D-OCT) image enhancement with segmentation-free contour modeling C-mode. Invest Ophthalmol Vis Sci. 2009;50:1344-1349.
78. Alam S, Zawadzki RJ, Choi S, et al. Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging. Ophthalmology. 2006;113:1425-1431.
79. Cucu RG, Podoleanu AG, Rogers JA, Pedro J, Rosen RB. Combined confocal/en face T-scan-based ultrahigh-resolution optical coherence tomography in vivo retinal imaging. Opt Lett. 2006; 31:1684-1686.
80. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146:496-500.
81. Lee EC, de Boer JF, Mujat M, Lim H, Yun SH. In vivo optical frequency domain imaging of human retina and choroid. Opt Express. 2006;14:4403-4411.
82. Miller DT, Qu J, Jonnal RS, Thorn K. Coherence gating and adaptive optics in the eye. In: Tuchin VV, Izatt JA, Fujimoto JG, eds. Coherence Domain Methods and Optical Coherence Tomography in Biomedicine VII. Proc SPIE. 2003;4596:65-72.
83. Zawadzki RJ, Jones SM, Olivier SS, et al. Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging. Opt Express. 2005;13:8532-8546.
84. Zawadzki RJ, Choi SS, Jones SM, Oliver SS, Werner JS. Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions. J Opt Soc Am A Opt Image Sci Vis. 2007;24:1373-1383.
85. Nolan W. Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography. Curr Opin Ophthalmol. 2008;19:115-121.
86. Radhakrishnan S, Rollins AM, Roth JE, et al. Real-time optical coherence tomography of the anterior segment at 1310 nm. Arch Ophthalmol. 2001;119:1179-1185.
87. Huang D, Li Y, Radhakrishnan S. Optical coherence tomography of the anterior segment of the eye. Ophthalmol Clin North Am. 2004;17:1-6.
88. Kagemann L, Wollstein G, Ishikawa H, et al. Identification and assessment of Schlemm's canal by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:4054-4059.
89. Radhakrishnan S, Huang D, Smith SD. Optical coherence tomography imaging of the anterior chamber angle. Ophthalmol Clin North Am. 2005;18:375-381, vi.
90. Tang M, Li Y, Avila M, Huang D. Measuring total corneal power before and after laser in situ keratomileusis with high-speed optical coherence tomography. J Cataract Refract Surg. 2006; 32:1843-1850.
91. Li Y, Shekhar R, Huang D. Corneal pachymetry mapping with high-speed optical coherence tomography. Ophthalmology. 2006;113:792-799 e792.
92. Li Y, Tang M, Zhang X, Salaroli CH, Ramos JL, Huang D. Pachymetric mapping with Fourier-domain optical coherence tomography. J Cataract Refract Surg. 2010;36:826-831.
93. Li Y, Netto MV, Shekhar R, Krueger RR, Huang D. A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography. Ophthalmology. 2007;114:1124-1132.
94. Li Y, Meisler DM, Tang M, et al. Keratoconus diagnosis with optical coherence tomography pachymetry mapping. Ophthalmology. 2008;115:2159-2166.
95. Zeng Y, Liu Y, Liu X, et al. Comparison of lens thickness measurements using the anterior segment optical coherence tomography and A-scan ultrasonography. Invest Ophthalmol Vis Sci. 2009;50:290-294.
96. Christopoulos V, Kagemann L, Wollstein G, et al. In vivo corneal high-speed, ultra high-resolution optical coherence tomography. Arch Ophthalmol. 2007;125:1027-1035.
97. Yaqoob Z, Wu J, Yang C. Spectral domain optical coherence tomography: a better OCT imaging strategy. BioTechniques. 2005;39:S6-S13.
98. Lim H, Mujat M, Kerbage C, et al. High-speed imaging of human retina in vivo with swept-source optical coherence tomography. Opt Express. 2006;14:12902-12908.
99. Srinivasan VJ, Huber R, Gorczynska I, et al. High-speed, highresolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm. Opt Lett. 2007;32:361-363.
100. de Bruin DM, Burnes DL, Loewenstein J, et al. In vivo threedimensional imaging of neovascular age-related macular degeneration using optical frequency domain imaging at 1050 nm. Invest Ophthalmol Vis Sci. 2008;49:4545-4552.
101. Yasuno Y, Hong Y, Makita S, et al. In vivo high-contrast imaging of deep posterior eye by 1-microm swept source optical coherence tomography and scattering optical coherence angiography. Opt Express. 2007;15:6121-6139.
102. Povazay B, Hermann B, Unterhuber A, et al. Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients. J Biomed Opt. 2007;12:041211.
103. Yasuno Y, Miura M, Kawana K, et al. Visualization of sub-retinal pigment epithelium morphologies of exudative macular diseases by high-penetration optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50:405-413.
104. Yun S, Tearney G, de Boer J, Iftimia N, Bouma B. High-speed optical frequency-domain imaging. Opt Express. 2003;11:2953-2963.
105. Yasuno Y, Madjarova VD, Makita S, et al. Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments. Opt Express. 2005;13:10652-10664.
106. Miura M, Mori H, Watanabe Y, et al. Three-dimensional optical coherence tomography of granular corneal dystrophy. Cornea. 2007;26:373-374.
107. Asrani S, Sarunic M, Santiago C, Izatt J. Detailed visualization of the anterior segment using fourier-domain optical coherence tomography. Arch Ophthalmol. 2008;126:765-771.
108. Yasuno Y, Yamanari M, Kawana K, Oshika T, Miura M. Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography. Opt Express. 2009;17:3980-3996.
109. Babcock HW. The possibility of compensating astronomical seeing. Publ Astron Soc Pac. 1953;65:229-236.
110. Hardy JW. Adaptive optics: a new technology for the control of light. Proc IEEE. 1978;66:651-697.
111. Liang J, Williams DR, Miller DT. Supernormal vision and highresolution retinal imaging through adaptive optics. J Opt Soc Am A Opt Image Sci Vis. 1997;14:2884-2892.
112. Roorda A, Williams DR. The arrangement of the three cone classes in the living human eye. Nature. 1999;397:520-522.
113. Hermann B, Fernandez EJ, Unterhuber A, et al. Adaptive-optics ultrahigh-resolution optical coherence tomography. Opt Lett. 2004;29:2142-2144.
114. Donnelly WJ, 3rd, Roorda A. Optimal pupil size in the human eye for axial resolution. J Opt Soc Am A Opt Image Sci Vis. 2003;20: 2010-2015.
115. Artal P, Guirao A, Berrio E, Williams DR. Compensation of corneal aberrations by the internal optics in the human eye. J Vis. 2001; 1:1-8.
116. Fernandez E, Drexler W. Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography. Opt Express. 2005;13: 8184-8197.
117. Fernandez EJ, Unterhuber A, Povazay B, Hermann B, Artal P, Drexler W. Chromatic aberration correction of the human eye for retinal imaging in the near infrared. Opt Express. 2006;14:6213-6225.
118. Zhang Y, Rha J, Jonnal R, Miller D. Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina. Opt Express. 2005;13:4792-4811.
119. Zhang Y, Cense B, Rha J, et al. High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography. Opt Express. 2006;14:4380-4394.
120. Hammer DX, Iftimia NV, Ferguson RD, et al. Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study. Invest Ophthalmol Vis Sci. 2008;49:2061-2070.
121. Choi SS, Zawadzki RJ, Keltner JL, Werner JS. Changes in cellular structures revealed by ultra-high resolution retinal imaging in optic neuropathies. Invest Ophthalmol Vis Sci. 2008;49:2103-2119.
122. Fernandez EJ, Povazay B, Hermann B, et al. Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator. Vision Res. 2005;45:3432-3444.
123. Zawadzki RJ, Choi SS, Fuller AR, Evans JW, Hamann B, Werner JS. Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography. Opt Express. 2009;17: 4084-4094.
124. Burns SA, Tumbar R, Elsner AE, Ferguson D, Hammer DX. Largefield-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope. J Opt Soc Am A Opt Image Sci Vis. 2007; 24:1313-1326.
125. de Boer JF, Milner TE, van Gemert MJ, Nelson JS. Two-dimensional birefringence imaging in biological tissue by polarizationsensitive optical coherence tomography. Opt Lett. 1997;22:934-936.
126. Wang XJ, Milner TE, de Boer JF, Zhang Y, Pashley DH, Nelson JS. Characterization of dentin and enamel by use of optical coherence tomography. Appl Opt. 1999;38:2092-2096.
127. Saxer CE, de Boer JF, Park BH, Zhao Y, Chen Z, Nelson JS. High-speed fiber based polarization-sensitive optical coherence tomography of in vivo human skin. Opt Lett. 2000;25:1355-1357.
128. Drexler W, Stamper D, Jesser C, et al. Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis. J Rheumatol. 2001;28: 1311-1318.
129. Ducros MG, Marsack JD, Rylander HG 3rd, Thomsen SL, Milner TE. Primate retina imaging with polarization-sensitive optical coherence tomography. J Opt Soc Am A Opt Image Sci Vis. 2001; 18:2945-2956.
130. Yamanari M, Lim Y, Makita S, Yasuno Y. Visualization of phase retardation of deep posterior eye by polarization-sensitive sweptsource optical coherence tomography with 1-microm probe. Opt Express. 2009;17:12385-12396.
131. Pircher M, Gotzinger E, Findl O, et al. Human macula investigated in vivo with polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2006;47:5487-5494.
132. Gotzinger E, Pircher M, Geitzenauer W, et al. Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. Opt Express. 2008;16:16410-16422.
133. Cense B, Gao W, Brown JM, et al. Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics. Opt Express. 2009;17:21634-21651.
134. Miura M, Yamanari M, Iwasaki T, et al. Imaging polarimetry in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:2661-2667.
135. Ahlers C, Gotzinger E, Pircher M, et al. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:2149-2157.
136. Gotzinger E, Pircher M, Sticker M, Fercher AF, Hitzenberger CK. Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography. J Biomed Opt. 2004;9:94-102.
137. Hitzenberger CK, Gotzinger E, Pircher M. Birefringence properties of the human cornea measured with polarization sensitive optical coherence tomography. Bull Soc Belge Ophtalmol. 2006; (302):153-168.
138. Pircher M, Gotzinger E, Baumann B, Hitzenberger CK. Corneal birefringence compensation for polarization sensitive optical coherence tomography of the human retina. J Biomed Opt. 2007; 12:041210.
139. Gotzinger E, Pircher M, Dejaco-Ruhswurm I, Kaminski S, Skorpik C, Hitzenberger CK. Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48:3551-3558.
140. Menke MN, Dabov S, Knecht P, Sturm V. Reproducibility of retinal thickness measurements in healthy subjects using spectralis optical coherence tomography. Am J Ophthalmol. 2009; 147:467-472.
141. Geerling G, Muller M, Winter C, et al. Intraoperative 2-dimensional optical coherence tomography as a new tool for anterior segment surgery. Arch Ophthalmol. 2005;123:253-257.
142. Dayani PN, Maldonado R, Farsiu S, Toth CA. Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery. Retina. 2009;29:1457-1468.
143. Galeotti J, Sajjad A, Wang B, et al. The OCT penlight: In-situ image guidance for microsurgery. Medical Imaging 2010: Visualization, Image-Guided Prodecures, and Modeling. SPIE Med Imaging. 2010;7625:2.0-2.6.
144. Boppart SA, Brezinski ME, Bouma BE, Tearney GJ, Fujimoto JG. Investigation of developing embryonic morphology using optical coherence tomography. Dev Biol. 1996;177:54-63.
145. Kagemann L, Ishikawa H, Zou J, et al. Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos. Mol Vis. 2008;14:2157-2170.
146. Zhou X, Xie J, Shen M, et al. Biometric measurement of the mouse eye using optical coherence tomography with focal plane advancement. Vision Res. 2008;48:1137-1143.
147. Zhou X, Shen M, Xie J, et al. The development of the refractive status and ocular growth in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2008;49:5208-5214.
148. Zhou X, Huang Q, An J, et al. Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice. Invest Ophthalmol Vis Sci. 2010;51:4362-4370.
149. Horio N, Kachi S, Hori K, et al. Progressive change of optical coherence tomography scans in retinal degeneration slow mice. Arch Ophthalmol. 2001;119:1329-1332.
150. Li Q, Timmers AM, Hunter K, et al. Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse. Invest Ophthalmol Vis Sci. 2001;42:2981-2989.
151. Srinivasan VJ, Ko TH, Wojtkowski M, et al. Noninvasive volumetric imaging and morphometry of the rodent retina with highspeed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2006;47:5522-5528.
152. Kocaoglu OP, Uhlhorn SR, Hernandez E, et al. Simultaneous fundus imaging and optical coherence tomography of the mouse retina. Invest Ophthalmol Vis Sci. 2007;48:1283-1289.
153. Kim KH, Puoris'haag M, Maguluri GN, et al. Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography. J Vis. 2008;8:17 11-11.
154. Fingler J, Readhead C, Schwartz DM, Fraser SE. Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid. Invest Ophthalmol Vis Sci. 2008;49:5055-5059.
155. Huber G, Beck SC, Grimm C, et al. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci. 2009;50:5888-5895.
156. Xu J, Molday LL, Molday RS, Sarunic MV. In vivo imaging of the mouse model of X-linked juvenile retinoschisis with fourier domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2009;50:2989-2993.
157. Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009;50:5435-5443.
158. Fischer MD, Huber G, Beck SC, et al. Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One. 2009;4:e7507.
159. Gabriele ML, Ishikawa H, Schuman JS, et al. Reproducibility of spectral-domain optical coherence tomography total retinal thickness measurements in mice. Invest Ophthalmol Vis Sci. 2010;51:6519-6523.
160. Ruggeri M, Tsechpenakis G, Jiao S, et al. Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography. Opt Express. 2009;17:4074-4083.
161. Doukas J, Mahesh S, Umeda N, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol. 2008;216:29-37.
162. Bai Y, Xu J, Brahimi F, Zhuo Y, Sarunic MV, Saragovi HU. An agonistic anti-TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma. Invest Ophthalmol Vis Sci. 2010;51: 4722-4731.
163. Nagata A, Higashide T, Ohkubo S, Takeda H, Sugiyama K. In vivo quantitative evaluation of the rat retinal nerve fiber layer with optical coherence tomography. Invest Ophthalmol Vis Sci. 2009; 50:2809-2815.
164. Guo L, Tsatourian V, Luong V, et al. En face optical coherence tomography: a new method to analyse structural changes of the optic nerve head in rat glaucoma. Br J Ophthalmol. 2005;89: 1210-1216.
165. Huang Y, Cideciyan AV, Papastergiou GI, et al. Relation of optical coherence tomography to microanatomy in normal and rd chickens. Invest Ophthalmol Vis Sci. 1998;39:2405-2416.
166. Ruggeri M, Major JC, McKeown C, Knighton RW, Puliafito CA, Jiao S. Retinal structure of birds of prey revealed by ultra-high resolution spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:5789-5795.
167. Gloesmann M, Hermann B, Schubert C, Sattmann H, Ahnelt PK, Drexler W. Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2003;44:1696-1703.
168. Gekeler F, Szurman P, Grisanti S, et al. Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs. Graefes Arch Clin Exp Ophthalmol. 2007;245:230-241.
169. Gekeler F, Gmeiner H, Volker M, et al. Assessment of the posterior segment of the cat eye by optical coherence tomography (OCT). Vet Ophthalmol. 2007;10:173-178.
170. Kim ET, Kim C, Lee SW, Seo JM, Chung H, Kim SJ. Feasibility of microelectrode array (MEA) based on silicone-polyimide hybrid for retina prosthesis. Invest Ophthalmol Vis Sci. 2009;50:4337-4341.
171. Cong L, Sun D, Zhang Z, Jiao W, Rizzolo LJ, Peng S. A novel rabbit model for studying RPE transplantation. Invest Ophthalmol Vis Sci. 2008;49:4115-4125.
172. Ameri H, Kim JG, Ratanapakorn T, Chader GJ, Humayun MS. Intravitreal and subretinal injection of tissue plasminogen activator (tPA) in the treatment of experimentally created retinal vein occlusion in rabbits. Retina. 2008;28:350-355.
173. Ameri H, Chader GJ, Kim JG, Sadda SR, Rao NA, Humayun MS. The effects of intravitreous bevacizumab on retinal neovascular membrane and normal
174. Qiu G, Stewart JM, Sadda S, et al. A new model of experimental subretinal neovascularization in the rabbit. Exp Eye Res. 2006; 83:141-152.
175. Kozak I, Cheng L, Mendez T, Davidson MC, Freeman WR. Evaluation of the toxicity of subretinal triamcinolone acetonide in the rabbit. Retina. 2006;26:811-817.
176. Asejczyk-Widlicka M, Schachar RA, Pierscionek BK. Optical coherence tomography measurements of the fresh porcine eye and response of the outer coats of the eye to volume increase. J Biomed Opt. 2008;13:024002.
177. Reiser BJ, Ignacio TS, Wang Y, et al. In vitro measurement of rabbit corneal epithelial thickness using ultrahigh resolution optical coherence tomography. Vet Ophthalmol. 2005;8:85-88.
178. Hosseini K, Kholodnykh AI, Petrova IY, Esenaliev RO, Hendrikse F, Motamedi M. Monitoring of rabbit cornea response to dehydration stress by optical coherence tomography. Invest Ophthalmol Vis Sci. 2004;45:2555-2562.
179. Kemp NJ, Park J, Zaatari HN, Rylander HG, Milner TE. Highsensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography. J Opt Soc Am A Opt Image Sci Vis. 2005;22:552-560.
180. Rylander HG 3rd, Kemp NJ, Park J, Zaatari HN, Milner TE. Birefringence of the primate retinal nerve fiber layer. Exp Eye Res. 2005;81:81-89.
181. Harwerth RS, Vilupuru AS, Rangaswamy NV, Smith EL 3rd. The relationship between nerve fiber layer and perimetry measurements. Invest Ophthalmol Vis Sci. 2007;48:763-773.
182. Schuman JS, Pedut-Kloizman T, Pakter H, et al. Optical coherence tomography and histologic measurements of nerve fiber layer thickness in normal and glaucomatous monkey eyes. Invest Ophthalmol Vis Sci. 2007;48:3645-3654.
183. Strouthidis NG, Yang H, Fortune B, Downs JC, Burgoyne CF. Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data sets. Invest Ophthalmol Vis Sci. 2009;50:214-223.
184. Strouthidis NG, Yang H, Reynaud JF, et al. Comparison of clinical and spectral domain optical coherence tomography optic disc margin anatomy. Invest Ophthalmol Vis Sci. 2009;50:4709-4718.
185. Strouthidis NG, Grimm J, Williams GA, Cull GA, Wilson DJ, Burgoyne CF. A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology. Invest Ophthalmol Vis Sci. 2010;51:1464-1474.
186. Fortune B, Yang H, Strouthidis NG, et al. The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness, and retardance. Invest Ophthalmol Vis Sci. 2009;50:4719-4726.