Host protein Ku70 binds and protects HIV-1 integrase from proteasomal degradation and is required for HIV replication

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 17722-17735

  Zheng, Yingfeng ^a   Ao, Zhujun ^a   Wang, Binchen ^a   Jayappa, Kallesh Danappa ^a   Yao, Xiaojian ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CELLULAR MACHINERY; HETERODIMERIZATION; HIV-1 INTEGRASE; HOST CELLS; HOST DEFENSE; HOST PROTEINS; LATE STAGE; N-TERMINALS; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; PROTEASOMAL PATHWAY; T CELLS; TARGET CELLS; UBIQUITIN-PROTEASOME SYSTEM; VIRAL PROTEINS; VIRAL REPLICATION;

INTEGRATION; MACHINERY; PROTEINS; VIRUSES;

DISEASES;

INTEGRASE; KU ANTIGEN; PROTEASOME;

AMINO TERMINAL SEQUENCE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOPRECIPITATION; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; UBIQUITINATION; VIRION; VIRUS ASSEMBLY; VIRUS REPLICATION;

ANTIGENS, NUCLEAR; CD4-POSITIVE T-LYMPHOCYTES; DNA-BINDING PROTEINS; HEK293 CELLS; HELA CELLS; HIV INTEGRASE; HIV-1; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; UBIQUITINATION; VIRUS ASSEMBLY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79955960397     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.184739     Document Type: Article

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